7-methyl-6-((1-methylpiperidin-4-yl)methoxy)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazine | 1025065-74-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 7-methyl-6-((1-methylpiperidin-4-yl)methoxy)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazine
• 英文别名: 7-Methyl-6-((1-methylpiperidin-4-yl)methoxy)-3-(3(trifluoromethoxy)phenyl) imidazo[1,2-b]pyridazine；7-methyl-6-[(1-methylpiperidin-4-yl)methoxy]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazine
• CAS: 1025065-74-0
• 化学式: C₂₁H₂₃F₃N₄O₂
• 分子量: 420.434
• InChiKey: VEAWFNZSVBDRFA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  51.9
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  1-甲基-4-哌啶甲醇 、 6-chloro-7-methyl-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazine 在 tris-(dibenzylideneacetone)dipalladium(0) 、 2-二环己膦基-2'-(N,N-二甲胺)-联苯 sodium t-butanolate 作用下， 以 甲苯 为溶剂， 以11.2%的产率得到7-methyl-6-((1-methylpiperidin-4-yl)methoxy)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazine
  参考文献：
  名称：

  WO2008/58126

  摘要：

  公开号：

文献信息

• IMIDAZO[1,2-beta]PYRIDAZINE AND PYRAZOLO[1,5-alpha]PYRIMIDINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS
  申请人：Bearss David J.

  公开号：US20080261988A1

  公开（公告）日：2008-10-23

  The present invention provides protein kinase inhibitors comprising imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine compounds of the following structure (I) and (II): or a stereoisomer, prodrug or pharmaceutically acceptable salt thereof, wherein R, R 1 , R 2 and X are as defined herein. Compositions and methods for using the same in the treatment of cancer and other Pim kinase-associated conditions are also disclosed.

  本发明提供了蛋白激酶抑制剂，包括以下结构（I）和（II）的咪唑[1,2-b]吡啶和吡唑[1,5-a]嘧啶化合物或其立体异构体、前药或药物可接受的盐，其中R、R1、R2和X如本文所定义。还公开了使用这些抑制剂治疗癌症和其他Pim激酶相关疾病的组合物和方法。
• Imidazo[1,2-beta]pyridazine and pyrazolo[1,5-alpha]pyrimidine derivatives and their use as protein kinase inhibitors
  申请人：SuperGen, Inc.

  公开号：US07750007B2

  公开（公告）日：2010-07-06

  The present invention provides protein kinase inhibitors comprising imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine compounds of the following structure (I) and (II): or a stereoisomer, prodrug or pharmaceutically acceptable salt thereof, wherein R, R1, R2 and X are as defined herein. Compositions and methods for using the same in the treatment of cancer and other Pim kinase-associated conditions are also disclosed.

  本发明提供了蛋白激酶抑制剂，包括以下结构的咪唑并[1,2-b]吡啶和吡唑并[1,5-a]嘧啶化合物(I)和(II)：或其立体异构体、前药或药学上可接受的盐，其中R、R1、R2和X如定义所述。还揭示了使用该抑制剂在治疗癌症和其他Pim激酶相关疾病中的组合物和方法。
• IMIDAZO[1,2-B]PYRIDAZINE AND PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS
  申请人：Bearss David J.

  公开号：US20110281863A1

  公开（公告）日：2011-11-17

  The present invention provides protein kinase inhibitors comprising imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine compounds of the following structure (I) and (II): or a stereoisomer, prodrug or pharmaceutically acceptable salt thereof, wherein R, R 1 , R 2 and X are as defined herein. Compositions and methods for using the same in the treatment of cancer and other Pim kinase-associated conditions are also disclosed.

  本发明提供蛋白激酶抑制剂，包括以下结构（I）和（II）的咪唑并[1,2-b]吡啶和吡唑并[1,5-a]嘧啶化合物的立体异构体、前药或药物可接受的盐，其中R、R1、R2和X如本文所定义。还公开了在治疗癌症和其他Pim激酶相关疾病中使用这些化合物的组合物和方法。
• Imidazo[1,2-B]pyridazine and pyrazolo[1 .5-A]pyrimidine derivatives and their use as protein kinase inhibitors
  申请人：Bearss David J.

  公开号：US08710057B2

  公开（公告）日：2014-04-29

  The present invention provides protein kinase inhibitors comprising imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine compounds of the following structure (I) and (II): or a stereoisomer, prodrug or pharmaceutically acceptable salt thereof, wherein R, R1, R2 and X are as defined herein. Compositions and methods for using the same in the treatment of cancer and other Pim kinase-associated conditions are also disclosed.

  本发明提供了以下结构（I）和（II）的咪唑并[1,2-b]吡嗪和吡唑并[1,5-a]嘧啶化合物的蛋白激酶抑制剂，或其立体异构体、前药或药物可接受盐，其中R，R1，R2和X如本文所定义。还公开了在治疗癌症和其他Pim激酶相关疾病中使用这些化合物的组合物和方法。
• IMIDAZOÝ1,2-B¨PYRIDAZINE AND PYRAZOLOÝ1,5-A¨PYRIMIDINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS
  申请人：SuperGen, Inc.

  公开号：EP2086979A2

  公开（公告）日：2009-08-12