n-octyl 1-thio-α-D-glucopyranoside | 128731-75-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: n-octyl 1-thio-α-D-glucopyranoside
• 英文别名: (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-octylsulfanyloxane-3,4,5-triol
• CAS: 128731-75-9
• 化学式: C₁₄H₂₈O₅S
• 分子量: 308.439
• InChiKey: CGVLVOOFCGWBCS-RKQHYHRCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  20
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  115
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  n-octyl 2,3,4,6-tetra-O-acetyl-1-thio-D-glucopyranoside 在 甲醇 、 三乙胺 作用下， 反应 24.0h， 生成 n-octyl 1-thio-α-D-glucopyranoside
  参考文献：
  名称：

  新的碳水化合物同系物同源系列n-烷基1-硫代-α-d-吡喃葡萄糖苷的合成及液晶性质

  摘要：

  摘要用1,2,3,4,6-五戊-O-乙酰基-β-d-吡喃葡萄糖处理1,2,3,4,6-戊-O-乙酰基-β-d-吡喃葡萄糖制备了n-烷基1-硫代-α-d-吡喃葡萄糖苷（正丙基至正十二烷基）。在三氟化硼醚化物的存在下链烷硫醇，然后脱乙酰化。正丙基和正丁基衍生物不是热致性的，正戊基衍生物是单亲的，具有正己基和较长烷基链的化合物是对映体的，n的最大液晶范围为±100–175° -十一烷基衍生物。转变点数据是近晶行为的典型特征，X射线数据和纹理观察表明近晶A d相。

  DOI：

  10.1016/0008-6215(89)85007-4

文献信息

• Reagent kits and methods for detecting malaria parasites by two-steps surfactant-mediated hemolysis
  申请人：Sysmex Corporation

  公开号：EP1406088A2

  公开（公告）日：2004-04-07

  Methods for detecting a malaria parasite are described that include: releasing the malaria parasite by allowing an erythrocyte in a specimen to undergo hemolysis in two steps by means of a first and a second hemolytic agents comprising surfactants; staining the released malaria parasite with a fluorescent dye to prepare a measurement sample; detecting optical information from the measurement sample; and distinguishing the malaria parasite based on the optical information obtained. The optical information is preferably fluorescent intensity and scattering light intensity, and is eventually obtained with the aid of a flow cytometer. The apparatus and the reagent kits for carrying out the invention are also described.

  所述检测疟原虫的方法包括：通过包含表面活性剂的第一和第二溶血剂，分两步让样本中的红细胞发生溶血，从而释放疟原虫；用荧光染料对释放的疟原虫进行染色，制备测量样本；检测测量样本中的光学信息；根据获得的光学信息区分疟原虫。光学信息最好是荧光强度和散射光强度，并最终借助流式细胞仪获得。此外，还介绍了用于实施本发明的仪器和试剂盒。
• Method of staining, detection and countiing bacteria, and a diluent for bacterial stain
  申请人：Sysmex Corporation

  公开号：US20020076743A1

  公开（公告）日：2002-06-20

  A method of staining bacteria comprises: working a polymethine dye on a sample in the presence of a substance capable of reducing nitrite ions to stain bacteria in the sample. A method of detecting bacteria comprises the following steps of: (1) working a polymethine dye on a sample by a method as described above to stain bacteria in the sample, (2) introducing the thus treated sample into a detecting part of a flow cytometer and irradiating cells of the stained bacteria one by one with light to measure scattered light and fluorescent light emitted from each of the cells; and (3) discriminating the bacteria from other components in accordance with an intensity of a scattered light signal and an intensity of a fluorescent light signal or a pulse width reflecting the length of particles to count the bacteria.

  一种对细菌染色的方法包括：在有能还原亚硝酸根离子的物质存在的情况下，将聚甲基染料作用于样品，对样品中的细菌进行染色。一种检测细菌的方法包括以下步骤：(1)用上述方法在样品上加工聚甲胺染料，使样品中的细菌染色；(2)将这样处理过的样品引入流式细胞仪的检测部分，用光逐个照射被染色细菌的细胞，测量每个细胞发出的散射光和荧光；(3)根据散射光信号的强度和荧光信号的强度或反映颗粒长度的脉冲宽度，将细菌与其他成分区分开来，对细菌进行计数。
• VAN, DOREN HENK A.;VAN, DER GEEST RALPH;KELLOGG, RICHARD M.;WYNBERG, HANS, CARBOHYDR. RES., 194,(1989) C. 71-77
  作者：VAN, DOREN HENK A.、VAN, DER GEEST RALPH、KELLOGG, RICHARD M.、WYNBERG, HANS

  DOI：——

  日期：——
• Method of staining, detecting and counting bacteria, and a diluent for bacterial stain
  申请人：SYSMEX CORPORATION

  公开号：EP1203825B1

  公开（公告）日：2005-09-21
• Methods for detecting malaria parasites and reagent kits therefor
  申请人：Sysmex Corporation

  公开号：US20040067575A1

  公开（公告）日：2004-04-08

  Methods for detecting a malaria parasite are described that include: releasing the malaria parasite by allowing an erythrocyte in a specimen to undergo hemolysis; staining the released malaria parasite with a fluorescent dye to prepare a measurement sample; detecting optical information from the measurement sample; and distinguishing the malaria parasite based on the optical information obtained. Apparatuses and reagent kits are also described.