N-acetyl-D-glucosamine-6-phosphate | 73495-11-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-acetyl-D-glucosamine-6-phosphate
• 英文别名: [(2R,3S,4R,5R,6S)-5-acetamido-3,4,6-trihydroxyoxan-2-yl]methyl dihydrogen phosphate
• CAS: 73495-11-1
• 化学式: C₈H₁₆NO₉P
• 分子量: 301.19
• InChiKey: BRGMHAYQAZFZDJ-PVFLNQBWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.2
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  166
• 氢给体数：
  6
• 氢受体数：
  9

文献信息

• Pathway Analysis of Cell Culture Phenotypes and Uses Thereof
  申请人：Melville Mark

  公开号：US20090186358A1

  公开（公告）日：2009-07-23

  The present invention provides methods for systematically identifying genes, proteins and/or related pathways that regulate or indicative of cell phenotypes. The present invention further provides methods for manipulating the identified genes, proteins and/or pathways to engineer improved cell lines and/or to evaluate or select cell lines with desirable phenotypes.
• Methods of Using a Bacterial GlcNAc-6-P 2'- Epimerase to Promote Sialylation of Glycoconjugates
  申请人：Geisler Christoph

  公开号：US20130029413A1

  公开（公告）日：2013-01-31

  The present invention relates to new methods to promote sialylation of glycoconjugates, including recombinant glycoproteins, in glycoconjugate production systems. The invention relates to methods to promote efficient glycoconjugate sialylation in recombinant expression systems, by providing simpler and more economical ways to produce large intracellular pools of sialic acid precursors. The invention is directed to nucleic acids, vectors, and cells harboring vectors comprising nucleic acids encoding enzymes involved in the synthesis of sialic acid precursors, and cells harboring these nucleic acids in combination with nucleic acids encoding glycosyltransferases, including sialyltransferases, to facilitate the production of humanized recombinant glycoproteins in bacterial, fungal, plant, and animal cell expression systems. The engineered cells can be used to produce glycosylated proteins in virally-infected, transiently-transformed, or stably-transformed host cells, including lepidopteran insects and cultured cell lines derived from Spodoptera frugiperda, Trichoplusia ni , and Bombyx mori that can be infected by baculovirus expression vectors.
• US20140283154A1
  申请人：——

  公开号：US20140283154A1

  公开（公告）日：2014-09-18
• US8846373B2
  申请人：——

  公开号：US8846373B2

  公开（公告）日：2014-09-30
• US9816107B2
  申请人：——

  公开号：US9816107B2

  公开（公告）日：2017-11-14