(6R)-6-methyl-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (6R)-6-methyl-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine
• 化学式: C₇H₁₀N₂O
• 分子量: 138.17
• InChiKey: IMMKANYCMSJHMF-ZCFIWIBFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  27
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• CHEMICAL COMPOUNDS AS INHIBITORS OF INTERLEUKIN-1 ACTIVITY
  申请人：Genentech, Inc.

  公开号：US20210395268A1

  公开（公告）日：2021-12-23

  The present disclosure relates to novel sulfonylurea and sulfonyl thiourea compounds and related compounds and their use in treating a disease or condition responsive to modulation of cytokines such as IL-1β and IL-18, modulation of NLRP3 or inhibition of the activation of NLRP3 or related components of the inflammatory process.