N-hydroxy-6-(5-phenyltriazol-1-yl)hexanamide | 1446713-17-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-hydroxy-6-(5-phenyltriazol-1-yl)hexanamide
• CAS: 1446713-17-2
• 化学式: C₁₄H₁₈N₄O₂
• 分子量: 274.323
• InChiKey: UERPGBWXIAEWMY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  80
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  methyl 6-(5-phenyl-1H-1,2,3-triazol-1-yl)hexanoate 在 盐酸羟胺 、 potassium hydroxide 作用下， 以 甲醇 为溶剂， 反应 3.0h， 以50%的产率得到N-hydroxy-6-(5-phenyltriazol-1-yl)hexanamide
  参考文献：
  名称：

  Development of a Chimeric c-Src Kinase and HDAC Inhibitor

  摘要：

  On the basis of synergism observed between a selective c-Src kinase inhibitor with an HDAC inhibitor, the development of the first chimeric c-Src kinase and HDAC inhibitor is described. The optimized chimeric inhibitor is shown to be a potent c-Src and HDAC inhibitor. Chimeric inhibitor 4 is further shown to be highly efficacious in cancer cell lines and significantly more efficacious than a dual-targeting strategy using discrete c-Src and HDAC inhibitors.

  DOI：

  10.1021/ml400175d

文献信息

• Development of a Chimeric c-Src Kinase and HDAC Inhibitor
  作者：Kristin S. Ko、Michael E. Steffey、Kristoffer R. Brandvold、Matthew B. Soellner

  DOI：10.1021/ml400175d

  日期：2013.8.8

  On the basis of synergism observed between a selective c-Src kinase inhibitor with an HDAC inhibitor, the development of the first chimeric c-Src kinase and HDAC inhibitor is described. The optimized chimeric inhibitor is shown to be a potent c-Src and HDAC inhibitor. Chimeric inhibitor 4 is further shown to be highly efficacious in cancer cell lines and significantly more efficacious than a dual-targeting strategy using discrete c-Src and HDAC inhibitors.