5-phthalimido-1-hexanol | 63895-93-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 5-phthalimido-1-hexanol
• 英文别名: 5-Phthalimidohexanol；2-(6-hydroxyhexan-2-yl)isoindole-1,3-dione
• CAS: 63895-93-2
• 化学式: C₁₄H₁₇NO₃
• 分子量: 247.294
• InChiKey: MSQDRPMHCADQEE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-phthalimido-1-hexanol 在 氯化亚砜 、 sodium iodide 作用下， 以 丙酮 、 苯 为溶剂， 反应 24.0h， 生成 1-iodo-5-phthalimidohexane
  参考文献：
  名称：

  Antimalarials. 13. 5-Alkoxy analogs of 4-methylprimaquine

  摘要：

  A series of nuclear and side-chain analogues of 4-methylprimaquine incorporating an alkoxy group in the 5-position of the quinoline nucleus has been prepared. The compounds were tested for suppressive antimalarial activity against Plasmodium berghei in mice and for radical curative antimalarial activity against Plasmodium cynomolgi in the rhesus monkey. Although the toxicity problems characteristic of the 8-aminoquinolines were not overcome, several of the compounds, surprisingly, were highly effective as both blood and tissue schizonticidal agents.

  DOI：

  10.1021/jm00350a016
• 作为产物：
  描述：

  5,6-二氢-3-乙氧羰基-2-甲基-4H-吡喃 在 镍 盐酸 、 ammonium hydroxide 、 氢气 作用下， 以 xylene 为溶剂， 反应 16.0h， 生成 5-phthalimido-1-hexanol
  参考文献：
  名称：

  Antimalarials. 13. 5-Alkoxy analogs of 4-methylprimaquine

  摘要：

  A series of nuclear and side-chain analogues of 4-methylprimaquine incorporating an alkoxy group in the 5-position of the quinoline nucleus has been prepared. The compounds were tested for suppressive antimalarial activity against Plasmodium berghei in mice and for radical curative antimalarial activity against Plasmodium cynomolgi in the rhesus monkey. Although the toxicity problems characteristic of the 8-aminoquinolines were not overcome, several of the compounds, surprisingly, were highly effective as both blood and tissue schizonticidal agents.

  DOI：

  10.1021/jm00350a016

文献信息

• Basic .alpha.-aminoalkylphosphonate derivatives
  申请人：Georgia Tech Research Corp.

  公开号：US05952307A1

  公开（公告）日：1999-09-14

  Peptidyl derivatives of diesters of .alpha.-aminoalkylphosphonic acids with basic substituents, their use in inhibiting serine proteases with trypsin-like specificity and their roles as anti-inflammatory agents, anticoagulants, and anti-tumor agents.

  α-氨基烷基膦酸双酯的肽衍生物，具有碱性取代基，用于抑制具有胰蛋白酶样特异性的丝氨酸蛋白酶，并作为抗炎剂，抗凝剂和抗肿瘤剂的作用。
• LAMONTAGNE, M. P.;MARKOVAC, A.;KHAN, M. S., J. MED. CHEM., 1982, 25, N 3, 964-968
  作者：LAMONTAGNE, M. P.、MARKOVAC, A.、KHAN, M. S.

  DOI：——

  日期：——
• Conformationally Constrained Smac Mimetics And The Uses Thereof
  申请人：Wang Shaomeng

  公开号：US20080132485A1

  公开（公告）日：2008-06-05

  The invention relates to conformationally constrained mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
• US5952307A
  申请人：——

  公开号：US5952307A

  公开（公告）日：1999-09-14
• US7674787B2
  申请人：——

  公开号：US7674787B2

  公开（公告）日：2010-03-09