(3aR,5aS,8aS,8bS)-5a-Azidomethyl-7,7-dimethyl-tetrahydro-[1,3,2]dioxathiolo[4,5-d][1,3]dioxalo[4,5-b]pyran 2,2-dioxide | 835894-59-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氧吡喃
• 英文名称: (3aR,5aS,8aS,8bS)-5a-Azidomethyl-7,7-dimethyl-tetrahydro-[1,3,2]dioxathiolo[4,5-d][1,3]dioxalo[4,5-b]pyran 2,2-dioxide
• 英文别名: (1S,2S,6R,9S)-9-(azidomethyl)-11,11-dimethyl-3,5,8,10,12-pentaoxa-4lambda6-thiatricyclo[7.3.0.02,6]dodecane 4,4-dioxide；(1S,2S,6R,9S)-9-(azidomethyl)-11,11-dimethyl-3,5,8,10,12-pentaoxa-4λ6-thiatricyclo[7.3.0.02,6]dodecane 4,4-dioxide
• CAS: 835894-59-2
• 化学式: C₉H₁₃N₃O₇S
• 分子量: 307.284
• InChiKey: NQHVWFQAFGEZRE-JAKMQLQISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  103
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  (3aR,5aS,8aS,8bS)-5a-Azidomethyl-7,7-dimethyl-tetrahydro-[1,3,2]dioxathiolo[4,5-d][1,3]dioxalo[4,5-b]pyran 2,2-dioxide 在 palladium on activated charcoal 氢气 、 磺酰胺 作用下， 以 1,4-二氧六环 、 乙醇 为溶剂， 23.0 ℃ 、289.58 kPa 条件下， 反应 24.5h， 生成 (1S,2S,6R,9S)-11,11-dimethyl-4,4-dioxo-9-[(sulfamoylamino)methyl]-3,5,8,10,12-pentaoxa-4lambda6-thiatricyclo[7.3.0.02,6]dodecane
  参考文献：
  名称：

  Comparison of Sulfamate and Sulfamide Groups for the Inhibition of Carbonic Anhydrase-II by Using Topiramate as a Structural Platform

  摘要：

  This paper examines the relative effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-II (CA-H). Topiramate (1) and its sulfamide analogue 4, and 4,5-cyclic sulfate 6 and its sulfamide analogue 5, were compared for inhibition of human CA-II. A colorimetric assay, based on the pH shift that accompanies hydration of carbon dioxide, and an esterase assay were used. For these bioisosteric pairs, 1/4 and 6/5, the sulfamate compound was markedly more potent than its sulfamide counterpart. A similar, large difference in potency was also observed for the sulfamate/sulfamide pairs 14/15 and 16/17. These results indicate that the sulfamide moiety is not particularly suitable for obtaining potent carbonic anhydrase inhibition. A discussion of this structure-activity relationship with respect to the interactions of 1 and 6 with CA-H from published X-ray data is presented. A metabolic acidosis study was performed in rats with 1, 4, 6, and 2, and the results are discussed with respect to the degree of inhibition of CA-II in vivo.

  DOI：

  10.1021/jm040124c
• 作为产物：
  描述：

  2,3-O-(isopropylidene)-4,5-O-sulfonyl-β-D-fructopyranose 在 吡啶 、 sodium azide 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 26.0h， 生成 (3aR,5aS,8aS,8bS)-5a-Azidomethyl-7,7-dimethyl-tetrahydro-[1,3,2]dioxathiolo[4,5-d][1,3]dioxalo[4,5-b]pyran 2,2-dioxide
  参考文献：
  名称：

  Comparison of Sulfamate and Sulfamide Groups for the Inhibition of Carbonic Anhydrase-II by Using Topiramate as a Structural Platform

  摘要：

  This paper examines the relative effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-II (CA-H). Topiramate (1) and its sulfamide analogue 4, and 4,5-cyclic sulfate 6 and its sulfamide analogue 5, were compared for inhibition of human CA-II. A colorimetric assay, based on the pH shift that accompanies hydration of carbon dioxide, and an esterase assay were used. For these bioisosteric pairs, 1/4 and 6/5, the sulfamate compound was markedly more potent than its sulfamide counterpart. A similar, large difference in potency was also observed for the sulfamate/sulfamide pairs 14/15 and 16/17. These results indicate that the sulfamide moiety is not particularly suitable for obtaining potent carbonic anhydrase inhibition. A discussion of this structure-activity relationship with respect to the interactions of 1 and 6 with CA-H from published X-ray data is presented. A metabolic acidosis study was performed in rats with 1, 4, 6, and 2, and the results are discussed with respect to the degree of inhibition of CA-II in vivo.

  DOI：

  10.1021/jm040124c

文献信息

• Comparison of Sulfamate and Sulfamide Groups for the Inhibition of Carbonic Anhydrase-II by Using Topiramate as a Structural Platform
  作者：Bruce E. Maryanoff、David F. McComsey、Michael J. Costanzo、Coralie Hochman、Virginia Smith-Swintosky、Richard P. Shank

  DOI：10.1021/jm040124c

  日期：2005.3.1

  This paper examines the relative effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-II (CA-H). Topiramate (1) and its sulfamide analogue 4, and 4,5-cyclic sulfate 6 and its sulfamide analogue 5, were compared for inhibition of human CA-II. A colorimetric assay, based on the pH shift that accompanies hydration of carbon dioxide, and an esterase assay were used. For these bioisosteric pairs, 1/4 and 6/5, the sulfamate compound was markedly more potent than its sulfamide counterpart. A similar, large difference in potency was also observed for the sulfamate/sulfamide pairs 14/15 and 16/17. These results indicate that the sulfamide moiety is not particularly suitable for obtaining potent carbonic anhydrase inhibition. A discussion of this structure-activity relationship with respect to the interactions of 1 and 6 with CA-H from published X-ray data is presented. A metabolic acidosis study was performed in rats with 1, 4, 6, and 2, and the results are discussed with respect to the degree of inhibition of CA-II in vivo.