2-methyl-N-[2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]propanamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-methyl-N-[2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]propanamide
• 化学式: C₁₀H₁₉NO₆
• 分子量: 249.26
• InChiKey: KXTUJUVCAGXOBN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  119
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• 2-(2-Hydroxybiphenyl-3-yl)-1H-Benzoimidazole-5-Carboxamidine Derivatives as Factor VIIA Inhibitors
  申请人：KOLESNIKOV Aleksandr

  公开号：US20090054432A1

  公开（公告）日：2009-02-26

  The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.

  本发明涉及新型 VIIa、IXa、Xa、XIa 因子的抑制剂，特别是 VIIa 因子的抑制剂，包括这些抑制剂的药物组合物，以及使用这些抑制剂治疗或预防血栓栓塞性疾病、癌症或类风湿关节炎的方法。本发明还公开了制备这些抑制剂的方法。
• 2-(2-HYDROXYBIPHENYL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE DERIVATIVES AS FACTOR VIIA INHIBITORS
  申请人：Kolesnikov Aleksandr

  公开号：US20110269806A1

  公开（公告）日：2011-11-03

  The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.

  本发明涉及新型因子VIIa、IXa、Xa、XIa抑制剂，特别是因子VIIa，以及包含这些抑制剂的制药组合物，以及使用这些抑制剂治疗或预防血栓栓塞性疾病、癌症或类风湿性关节炎的方法。本发明还公开了制备这些抑制剂的过程。
• 2-(2-HYDROXYBIPHENYL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE DERIVATIVES AS FACTOR VIIA INHIBITORS FOR THE TREATMENT OF THROMBOEMBOLIC DISORDERS
  申请人：Pharmacyclics LLC

  公开号：EP2982668A2

  公开（公告）日：2016-02-10

  The present invention relates to 2-(2-hydroxybiphenyl-3-yl)-1H-benzoimidazole-5-carboxamidine derivatives as factor VIIa inhibitors for the treatment of thromboembolic disorders, cancers and rheumatoid arthritis. Processes for preparing these inhibitors and intermediates thereof are also disclosed.

  本发明涉及作为因子 VIIa 抑制剂的 2-(2-羟基联苯-3-基)-1H-苯并咪唑-5-甲脒衍生物，用于治疗血栓栓塞性疾病、癌症和类风湿性关节炎。还公开了制备这些抑制剂及其中间体的工艺。
• [EN] MODIFIED CYANINE DYES AND CONJUGATES THEREOF<br/>[FR] COLORANTS CYANINE MODIFIÉS ET CONJUGUÉS DE CEUX-CI
  申请人：BRACCO IMAGING SPA

  公开号：WO2020229438A9

  公开（公告）日：2021-08-12
• HBED-Bisphosphonates, Radiometal Conjugates and Their Use as Theranostic Agents
  申请人：Five Eleven Pharma Inc.

  公开号：US20170022224A1

  公开（公告）日：2017-01-26

  The present invention relates to compounds according to Formula I or Formula II, which are potential bone imaging agents. Certain compounds labeled with 68 Ga displayed excellent bone uptake and retention. The present invention also relates to pharmaceutical compositions comprising a pharmaceutical acceptable carrier and a compound of Formula I or Formula II or a pharmaceutically acceptable salt thereof.