1-[(4,4-Dimethyl-3-oxo-pentyl)-isopropyl-amino]-4,4-dimethyl-pentan-3-one | 130539-93-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[(4,4-Dimethyl-3-oxo-pentyl)-isopropyl-amino]-4,4-dimethyl-pentan-3-one
• 英文别名: 1-[(4,4-Dimethyl-3-oxopentyl)-propan-2-ylamino]-4,4-dimethylpentan-3-one
• CAS: 130539-93-4
• 化学式: C₁₇H₃₃NO₂
• 分子量: 283.455
• InChiKey: BTQOCKNCAOIVGY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  20
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N,N-bis(ethoxymethyl)-iso-propylamine 、 (1-叔丁基乙烯氧基)三甲基硅烷 生成 1-[(4,4-Dimethyl-3-oxo-pentyl)-isopropyl-amino]-4,4-dimethyl-pentan-3-one
  参考文献：
  名称：

  EARLE, MARTYN J.;FAIRHURST, ROBIN A.;HEANEY, HARRY;PAPAGEORGIOU, GEORGE;W+, TETRAHEDRON LETT., 31,(1990) N9, C. 4229-4232

  摘要：

  DOI：

文献信息

• A new route to secondary amines from bis-(alkoxymethyl)-alkylamines - the activation of an aminomethyl group and protection of the product by the same functional group
  作者：Martyn J. Earle、Robin A. Fairhurst、Harry Heaney、George Papageorgiou、Robert F. Wilkins

  DOI：10.1016/s0040-4039(00)97589-0

  日期：1990.1

  variety of acidic reagents affords good yields of N-alkoxymethyl-N-alkylmethyleneiminium salts which react with trimethylsilyl enol ethers, and nucleophilic aromatic substrates to form protected secondary amines or tertiary amines by domino reactions; silyl ketene acetals afford tertiary amines only.

  的治疗N，N- -双用各种酸性试剂，得到良好的产率的（烷氧基）烷基胺Ñ -alkoxymethyl- Ñ -alkylmethyleneiminium盐，其与三甲基甲硅烷烯醇醚反应，亲核芳族底物，通过多米诺形式保护的仲胺或叔胺反应; 甲硅烷基乙烯酮缩醛仅提供叔胺。
• Poly(Tetrafluoroethene) Polymer With Nitric Oxide Donating Surface
  申请人：Chen Mingfei

  公开号：US20100256755A1

  公开（公告）日：2010-10-07

  Described herein are nitric oxide (NO)-donating poly(tetrafluoroethylene) (PTFE) polymers and polymer surfaces and methods of making and using the same. The NO-donating PTFE polymers can be used to fabricate at least a portion of an implantable medical device, coat at least a portion of an implantable medical device or form at least a portion of an implantable medical device. The NO-donating PTFE polymers provide controlled release of NO once implanted at or within the target site.
• POLY(TETRAFLUOROETHYLENE) POLYMER WITH NITRIC OXIDE DONATING SURFACE
  申请人：CHEN Mingfei

  公开号：US20120269897A1

  公开（公告）日：2012-10-25

  Described herein are nitric oxide (NO)-donating poly(tetrafluoroethylene) (PTFE) polymers and polymer surfaces and methods of making and using the same. The NO-donating PTFE polymers can be used to fabricate at least a portion of an implantable medical device, coat at least a portion of an implantable medical device or form at least a portion of an implantable medical device. The NO-donating PTFE polymers provide controlled release of NO once implanted at or within the target site.
• US8236341B2
  申请人：——

  公开号：US8236341B2

  公开（公告）日：2012-08-07