(E)-3-(2-(allyloxy)phenyl)-1-(2,4-dihydroxyphenyl)prop-2-en-1-one | 1338672-37-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (E)-3-(2-(allyloxy)phenyl)-1-(2,4-dihydroxyphenyl)prop-2-en-1-one
• 英文别名: (E)-1-(2,4-dihydroxyphenyl)-3-(2-allyloxyphenyl)-2-propen-1-one；(E)-3-(2-allyloxyphenyl)-1-(2,4-dihydroxyphenyl)prop-2-en-1-one；(E)-1-(2,4-dihydroxyphenyl)-3-(2-prop-2-enoxyphenyl)prop-2-en-1-one
• CAS: 1338672-37-9
• 化学式: C₁₈H₁₆O₄
• 分子量: 296.323
• InChiKey: JOUAFGREHOHSPE-JXMROGBWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (E)-3-(2-(allyloxy)phenyl)-1-(2,4-dihydroxyphenyl)prop-2-en-1-one 在 盐酸 作用下， 以 乙醇 、 水 为溶剂， 反应 1.5h， 以50%的产率得到2-(2-(allyloxy)phenyl)-7-hydroxychroman-4-one
  参考文献：
  名称：

  Synthesis, Structure–Activity Relationship Studies, and Antibacterial Evaluation of 4-Chromanones and Chalcones, as Well as Olympicin A and Derivatives

  摘要：

  On the basis of recently reported abyssinone II and olympicin A, a series of chemically modified flavonoid phytochemicals were synthesized and evaluated against Mycobacterium tuberculosis and a panel of Gram-positive and -negative bacterial pathogens. Some of the synthesized compounds exhibited good antibacterial activities against Gram-positive pathogens including methicillin resistant Staphylococcus aureus with minimum inhibitory concentration as low as 0.39 mu g/mL. SAR analysis revealed that the 2-hydrophobic substituent and the 4-hydrogen bond donor/acceptor of the 4-chromanone scaffold together with the hydroxy groups at 5- and 7-positions enhanced antibacterial activities; the 2',4'-dihydroxylated A ring and the lipophilic substituted B ring of chalcone derivatives were pharmacophoric elements for antibacterial activities. Mode of action studies performed on selected compounds revealed that they dissipated the bacterial membrane potential, resulting in the inhibition of macromolecular biosynthesis; further studies showed that selected compounds inhibited DNA topoisomerase IV, suggesting complex mechanisms of actions for compounds in this series.

  DOI：

  10.1021/jm500853v
• 作为产物：
  描述：

  1-[2-羟基-4-(甲氧基甲氧基)苯基]乙酮 在 盐酸 、 potassium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 反应 60.0h， 生成 (E)-3-(2-(allyloxy)phenyl)-1-(2,4-dihydroxyphenyl)prop-2-en-1-one
  参考文献：
  名称：

  Synthesis, Structure–Activity Relationship Studies, and Antibacterial Evaluation of 4-Chromanones and Chalcones, as Well as Olympicin A and Derivatives

  摘要：

  On the basis of recently reported abyssinone II and olympicin A, a series of chemically modified flavonoid phytochemicals were synthesized and evaluated against Mycobacterium tuberculosis and a panel of Gram-positive and -negative bacterial pathogens. Some of the synthesized compounds exhibited good antibacterial activities against Gram-positive pathogens including methicillin resistant Staphylococcus aureus with minimum inhibitory concentration as low as 0.39 mu g/mL. SAR analysis revealed that the 2-hydrophobic substituent and the 4-hydrogen bond donor/acceptor of the 4-chromanone scaffold together with the hydroxy groups at 5- and 7-positions enhanced antibacterial activities; the 2',4'-dihydroxylated A ring and the lipophilic substituted B ring of chalcone derivatives were pharmacophoric elements for antibacterial activities. Mode of action studies performed on selected compounds revealed that they dissipated the bacterial membrane potential, resulting in the inhibition of macromolecular biosynthesis; further studies showed that selected compounds inhibited DNA topoisomerase IV, suggesting complex mechanisms of actions for compounds in this series.

  DOI：

  10.1021/jm500853v

文献信息

• Design, synthesis and SAR study of hydroxychalcone inhibitors of human β-secretase (BACE1)
  作者：Lei Ma、Zhengyi Yang、Chenjing Li、Zhiyuan Zhu、Xu Shen、Lihong Hu

  DOI：10.3109/14756366.2010.543420

  日期：2011.10.1

  According to the structural characteristics of isoliquiritigenin from Glycyrrhiza uralensis, a series of hydroxychalcones has been designed, synthesized and evaluated for their in vitro inhibitory activities of beta-secretase (BACE1). Structure-activity relationship study suggested that inhibitory activity against BACE1 was governed to a greater extent by the hydroxyl substituent on A- and B-ring of the chalcone, and the most active compound was substituted with four hydroxyl group (17, IC(50) = 0.27 mu M).
• Synthesis, Structure–Activity Relationship Studies, and Antibacterial Evaluation of 4-Chromanones and Chalcones, as Well as Olympicin A and Derivatives
  作者：Li Feng、Marcus M. Maddox、Md. Zahidul Alam、Lissa S. Tsutsumi、Gagandeep Narula、David F. Bruhn、Xiaoqian Wu、Shayna Sandhaus、Robin B. Lee、Charles J. Simmons、Yuk-Ching Tse-Dinh、Julian G. Hurdle、Richard E. Lee、Dianqing Sun

  DOI：10.1021/jm500853v

  日期：2014.10.23

  On the basis of recently reported abyssinone II and olympicin A, a series of chemically modified flavonoid phytochemicals were synthesized and evaluated against Mycobacterium tuberculosis and a panel of Gram-positive and -negative bacterial pathogens. Some of the synthesized compounds exhibited good antibacterial activities against Gram-positive pathogens including methicillin resistant Staphylococcus aureus with minimum inhibitory concentration as low as 0.39 mu g/mL. SAR analysis revealed that the 2-hydrophobic substituent and the 4-hydrogen bond donor/acceptor of the 4-chromanone scaffold together with the hydroxy groups at 5- and 7-positions enhanced antibacterial activities; the 2',4'-dihydroxylated A ring and the lipophilic substituted B ring of chalcone derivatives were pharmacophoric elements for antibacterial activities. Mode of action studies performed on selected compounds revealed that they dissipated the bacterial membrane potential, resulting in the inhibition of macromolecular biosynthesis; further studies showed that selected compounds inhibited DNA topoisomerase IV, suggesting complex mechanisms of actions for compounds in this series.