N-(2-methoxyethyl)heptanamide | 512173-23-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-(2-methoxyethyl)heptanamide
• CAS: 512173-23-8
• 化学式: C₁₀H₂₁NO₂
• mdl: MFCD03395448
• 分子量: 187.282
• InChiKey: GBCJFEZTXPPNOK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  13
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  一氧化碳 、 1-碘己烷 、 2-甲氧基乙胺 在 2,2'-联吡啶 、 copper(I) bromide dimethylsulfide complex 、 caesium carbonate 作用下， 以 1,4-二氧六环 为溶剂， 110.0 ℃ 、4.0 MPa 条件下， 反应 15.0h， 以84%的产率得到N-(2-methoxyethyl)heptanamide
  参考文献：
  名称：

  铜催化底物控制羰基合成α-酮酰胺和烷基卤化物

  摘要：

  已经开发了一种铜催化的烷基溴和胺的高选择性双羰基化反应。获得所需的α-酮酰胺作为唯一的产物。随后，在不同条件下，还实现了烷基碘与胺的双羰基化和单羰基化。

  DOI：

  10.1002/anie.202200062

文献信息

• Catalytic transamidation and amide metathesis under moderate conditions
  申请人：——

  公开号：US20040230078A1

  公开（公告）日：2004-11-18

  Disclosed is a method of manipulating the carboxamide functionality in a catalytic manner. The method includes the steps of reacting amides with or without amines in the presence of various types of metal catalysts, at a temperature of about 250° C. or less.

  本方法揭示了一种以催化方式操纵羧酰胺功能的方法。该方法包括在各种类型的金属催化剂存在下，以约250°C或更低的温度，将酰胺与或不与胺反应的步骤。
• PHOSPHINE DERIVATIVES OF FLUORESCENT COMPOUNDS
  申请人：Hermanson Greg

  公开号：US20150119281A1

  公开（公告）日：2015-04-30

  A phosphine derivative of DyLight dyes modified with ethylene glycol or (poly)ethylene glycol groups. In one embodiment, the compounds are useful in chemoselective ligation reactions.

  一种磷氢化物衍生的DyLight染料，经过乙二醇或（聚）乙二醇基团修饰。在一种实施方案中，这些化合物在化学选择性连接反应中非常有用。
• FLUORESCENT COMPOUNDS
  申请人：Hermanson Greg

  公开号：US20130251637A9

  公开（公告）日：2013-09-26

  Compounds used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.

  本文介绍了一些具有与已知荧光化合物类似性质的标签化合物。这些化合物可以与蛋白质和核酸共轭，用于生物成像和分析。文中提供了这些化合物的合成、共轭化合物的形成和使用，以及每种化合物的具体非限制性示例。
• CYANINE COMPOUNDS
  申请人：Hermanson Greg

  公开号：US20160168383A1

  公开（公告）日：2016-06-16

  Compounds used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.

  本发明涉及用作标记的化合物，其性质可与已知荧光化合物相媲美。这些化合物可与蛋白质和核酸共轭，用于生物成像和分析。本发明提供了这些化合物的合成，共轭化合物的形成和使用，以及每种化合物的具体非限制性示例。
• POSITIVELY CHARGED SPECIES AS BINDING REAGENTS IN THE SEPARATION OF PROTEIN AGGREGATES FROM MONOMERS
  申请人：Peretz David

  公开号：US20130109581A1

  公开（公告）日：2013-05-02

  The invention provides methods for detecting the presence of an aggregate in a sample by contacting the sample suspected of containing an aggregate with an aggregate-specific binding reagent under conditions that allow the binding of the reagent to the aggregate, if present; and detecting the presence of the aggregate, if any, in the sample by its binding to the reagent; where the aggregate-specific binding reagent typically has a net charge of at least about positive one at the pH at which the sample is contacted with the ASB reagent, is attached to a solid support at a charge density of at least about 60 nmol net charge per square meter, and binds preferentially with aggregates over monomers when attached to the solid support. Methods for detecting the presence of oligomer are also provided. Compositions for use in the methods are provided.