苯基葡糖苷酸 | 16063-67-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 苯基葡糖苷酸
• 英文名称: phenol glucuronide
• 英文别名: phenyl glucuronide；phenyl-glucuronide；O¹-phenyl-glucopyranuronic acid；O¹-Phenyl-glucopyranuronsaeure；Phenolglykuronsaeure；Phenylglucuronide；(2S,3S,4S,5R)-3,4,5-trihydroxy-6-phenoxyoxane-2-carboxylic acid
• CAS: 16063-67-5
• 化学式: C₁₂H₁₄O₇
• 分子量: 270.239
• InChiKey: WVHAUDNUGBNUDZ-SDQGTYQYSA-N

物化性质

• 沸点：
  542.0±50.0 °C(Predicted)
• 密度：
  1.587±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  116
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  potassium phenolate 、 alkaline earth salt of/the/ methylsulfuric acid 生成 苯基葡糖苷酸
  参考文献：
  名称：

  Neuberg; Neimann, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1905, vol. 44, p. 103

  摘要：

  DOI：

文献信息

• Chromogenic chemical substrates for identification of microbial colonies
  申请人：Rambach, Alain

  公开号：EP0025467A1

  公开（公告）日：1981-03-25

  Chromogenic substrate member for identifying Escherichia coli bacteria. It comprises a growing medium for said bacteria and container means (1) for the growing medium (4) and a liquid sample to be tested. The container means also contains a chromogenic reagent compound consisting in 8-hydroxyquinoline-β-D glucuronide and an activator compound consisting in X-glucuronide where X is selected from the group consisting in alkyl, aryl or indoxyl radical, the halogeno substitutes and the nitro substitutes thereof.

  用于鉴定大肠杆菌的致色底物部件。它包括一个供所述细菌生长的培养基和一个容器装置（1），用于盛放生长培养基（4）和待测液体样品。容器装置还包含由 8-羟基喹啉-β-D-葡萄糖醛酸组成的发色试剂化合物和由 X-葡萄糖醛酸组成的活化剂化合物，其中 X 选自烷基、芳基或吲哚基、其卤代物和硝基代物组成的组。
• Use of UGT inhibitors to increase bioavailability
  申请人：——

  公开号：US20030215462A1

  公开（公告）日：2003-11-20

  Methods for increasing the bioavailability of certain orally administered pharmaceutical compounds by the coadministration of inhibitors of UDP-glucuronosyltransferase (UGT) are disclosed. Particular combinations of UGT inhibitors and pharmaceutical compound are described.

  本研究公开了通过联合使用 UDP-葡萄糖醛酸转移酶（UGT）抑制剂来提高某些口服药物的生物利用度的方法。文中描述了 UGT 抑制剂和药物化合物的特定组合。
• Method for detecting microorganisms
  申请人：Rambach Alain

  公开号：US20050118667A1

  公开（公告）日：2005-06-02

  The invention concerns a method for detecting microorganisms present in a sample, which consists in inoculating a culture medium with said sample, said culture medium preferably containing chromogens releasing chromophores in the presence of target microorganisms or fluorogens, said culture medium being in a container with a coloured base, detection being facilitated by contrast between the coloured base and the isolated colonies.

  本发明涉及一种检测样品中微生物的方法，该方法包括将培养基接种到所述样品中，所述培养基最好含有在目标微生物或荧光剂存在时释放发色团的发色剂，所述培养基装在带有彩色基底的容器中，通过彩色基底与分离菌落之间的对比来促进检测。
• Process for preparation of mycophenolic acid and ester derivatives thereof
  申请人：Keri Vilmos

  公开号：US20050250952A1

  公开（公告）日：2005-11-10

  Provided are processes for preparation of mycophenolic acid.

  提供了制备霉酚酸的工艺。
• Method for the determination of glucuronides in physiological samples
  申请人：LaCourse R. William

  公开号：US20060019400A1

  公开（公告）日：2006-01-26

  The present invention provides methods and kits for the detection of glucuronide metabolites of various drugs, alcohols and other compounds using a combination of High Performance Liquid Chromatography coupled with Pulsed Electrochemical Detection. Detection of a drug and its glucuronide metabolite(s) has applications in interpretive forensic and clinical toxicology. The ability to estimate metabolite/drug ratios enables the assessment of route, dose and time of exposure. In instances where the parent drug is biotransformed quickly and can only found in low levels in biological fluids, the detection of metabolites allows for the identification of parent drugs. Furthermore, metabolite determination enables the differentiation between recent and chronic drug use.

  本发明提供了结合使用高效液相色谱法和脉冲电化学检测法检测各种药物、酒精和其他化合物的葡萄糖醛酸代谢物的方法和试剂盒。药物及其葡萄糖醛酸代谢物的检测可用于法医和临床毒理学的解释。通过估算代谢物/药物比率，可以评估药物接触的途径、剂量和时间。如果母体药物很快发生生物转化，只能在生物体液中发现低浓度的代谢物，那么检测代谢物就可以确定母体药物。此外，代谢物测定还能区分近期吸毒和长期吸毒。