2-Isopropyl-2-methyl-cyclohexanon | 17206-50-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Isopropyl-2-methyl-cyclohexanon
• 英文别名: 6-Isopropyl-6-methyl-cyclohexanon；2-Methyl-2-isopropyl-cyclohexanon；Methyl-Isopropylcyclohexanon；2-methyl-2-propan-2-ylcyclohexan-1-one
• CAS: 17206-50-7
• 化学式: C₁₀H₁₈O
• 分子量: 154.252
• InChiKey: XVSHBGZATWUKDY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-(1-Ethylsulfanyl-1-methyl-ethyl)-2-methyl-cyclohexanone 在 镍 作用下， 生成 2-Isopropyl-2-methyl-cyclohexanon
  参考文献：
  名称：

  Reetz, M. T.; Giannis, A., Synthetic Communications, 1981, vol. 11, # 4, p. 315 - 322

  摘要：

  DOI：

文献信息

• THE DEAMINATION OF ALICYCLIC α-AMINOKETONES
  作者：O. E. Edwards、M. Lesage

  DOI：10.1139/v63-218

  日期：1963.6.1

  α-aminocyclohexanones has been shown to give cyclopentane carboxylic acids, bicyclo[3,1,0]hexane-2-ones, and 2-methyl-2-cyclopentene-1-ones. Deamination of 3-endo-aminocamphor gave cyclocamphanone, 6-isopropenyl-6-methyl-2-cyclohexen-1-one, and 6- (1′-hydroxy-1′-methylethyl)-6-methyl-2-cyclohexen-1-one.The formation of bicyclo[3,1,0]hexane by deamination of cyclohexylamine is reported for the first time. The

  已显示 α-氨基环己酮的脱氨基得到环戊烷羧酸、双环 [3,1,0] 己烷-2-酮和 2-甲基-2-环戊烯-1-酮。3-endo-aminocamphor 脱氨基得到环樟酮、6-isopropenyl-6-methyl-2-cyclohexen-1-one 和 6-(1'-hydroxy-1'-methylethyl)-6-methyl-2-cyclohexen-1一、首次报道了环己胺脱氨基生成双环[3,1,0]己烷。它和冰片胺的产物与相应的α-氨基酮产物之间的差异是根据C-C参与相应碳正离子的量来合理化的。
• Action du magnesium sur les nitriles ω-halogenes
  作者：M. Larcheveque、A. Debal、Th. Cuvigny

  DOI：10.1016/s0022-328x(00)80339-3

  日期：1975.3

  δ- and ϵ-Iodonitriles react with magnesium in ether at room temperature to give substituted cyclopentanones and cyclohexanones by intramolecular cyclisation.

  室温下，δ-和ϵ-碘腈与镁在乙醚中反应，通过分子内环化反应生成取代的环戊酮和环己酮。
• A PROCESS FOR THE PRODUCTION OF A MIXTURE COMPRISING CYCLOHEXANOL AND CYCLOHEXANONE
  申请人：CAP III B.V.

  公开号：EP3115350A1

  公开（公告）日：2017-01-11

  A continuous process for the production of a mixture comprising cyclohexanone and cyclohexanol by hydrogenation of phenol, which process is performed in a multi-tubular reactor, characterised in that said multi-tubular reactor has been used for the dehydrogenation of cyclohexanol; a chemical plant suitable for the hydrogenation of phenol comprising a multi-tubular reactor; cyclohexanone prepared in a chemical plant comprising a multi-tubular reactor; and a process for constructing such a plant.

  一种通过苯酚氢化生产由环己酮和环己醇组成的混合物的连续工艺，该工艺在多管式反应器中进行，其特征在于所述多管式反应器用于环己醇的脱氢；一种适用于苯酚氢化的化工装置，包括一个多管式反应器；在包括一个多管式反应器的化工装置中制备的环己酮；以及建造这种装置的工艺。
• A PROCESS FOR THE PRODUCTION OF A MIXTURE COMPRISING CYCLOHEXANONE AND CYCLOHEXANOL
  申请人：CAP III B.V.

  公开号：EP3095774A1

  公开（公告）日：2016-11-23

  A continuous process for the production of a mixture comprising cyclohexanone and cyclohexanol by hydrogenation of phenol, which process is performed in a chemical plant comprising a multi-tubular reactor characterised in that said multi-tubular reactor has been used for the hydrogenation of benzene; a chemical plant suitable for the hydrogenation of phenol comprising a multi-tubular reactor; cyclohexanone prepared in a chemical plant comprising a multi-tubular reactor; and a process for constructing such a plant.

  一种通过苯酚氢化生产由环己酮和环己醇组成的混合物的连续工艺，该工艺在一个包括多管式反应器的化工装置中进行，其特征在于所述多管式反应器曾用于苯的氢化；一种适用于苯酚氢化的化工装置，包括一个多管式反应器；在一个包括多管式反应器的化工装置中制备环己酮；以及一种建造这种装置的工艺。
• Process for revamping a plant for the production of cyclohexanone
  申请人：CAP III B.V.

  公开号：US10130895B2

  公开（公告）日：2018-11-20

  A process for the construction of a second chemical plant, which second chemical plant is suitable for the separation of cyclohexanone from a second mixture, which second mixture comprises reaction products from the hydrogenation of phenol. The process comprises providing a first chemical plant, which first chemical plant is suitable for the separation of cyclohexanone from a first mixture, and a second chemical plant comprising a distillation column suitable for distilling overhead cyclohexanone reused from the first chemical plant.

  一种建造第二化工厂的工艺，该第二化工厂适用于从第二混合物中分离环己酮，该第二混合物包括苯酚氢化反应产物。该工艺包括提供一个第一化学工厂，该第一化学工厂适用于从第一混合物中分离环己酮；以及一个第二化学工厂，该第二化学工厂包括一个蒸馏塔，该蒸馏塔适用于蒸馏从第一化学工厂重复使用的架空环己酮。