7-Phenyl-6,7-dihydro-5H-8-oxa-1,4-diaza-triphenylene | 833122-46-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 7-Phenyl-6,7-dihydro-5H-8-oxa-1,4-diaza-triphenylene
• 英文别名: 5H-Benzo[f]pyrano[2,3-h]quinoxaline, 6,7-dihydro-7-phenyl-；11-phenyl-12-oxa-3,6-diazatetracyclo[12.4.0.02,7.08,13]octadeca-1(18),2,4,6,8(13),14,16-heptaene
• CAS: 833122-46-6
• 化学式: C₂₁H₁₆N₂O
• 分子量: 312.371
• InChiKey: HEDNPCUQHCAELL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  24
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  35
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  7-Phenyl-6,7-dihydro-5H-8-oxa-1,4-diaza-triphenylene 在 臭氧 、 二甲基硫 作用下， 以 二氯甲烷 为溶剂， 以53%的产率得到8-phenyl-7,8-dihydro-6H-[2]benzoxecino[7,8-b]pyrazine-5,10-dione
  参考文献：
  名称：

  Synthesis of 9- and 10-membered macrolactones by selective ozonolysis of 1,4-diazaphenanthrene derivatives

  摘要：

  9- and 10-membered macrolactones bearing benzo and diazine rings were obtained by chemoselective ozonolysis of dihydrofuran and pyran 1,4-diazaphenathrene derivatives. This is the first example of preparation of macrolactones by chemoselective ozonolysis of an enol double bond shared by aromatic and heterocyclic rings. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.10.075
• 作为产物：
  描述：

  2-phenyl-3,4-dihydro-2H-benzo[h]chromene-5,6-dione 、 乙二胺 在 4 A molecular sieve 作用下， 以 甲苯 为溶剂， 反应 24.0h， 以51%的产率得到7-Phenyl-6,7-dihydro-5H-8-oxa-1,4-diaza-triphenylene
  参考文献：
  名称：

  Synthesis of 9- and 10-membered macrolactones by selective ozonolysis of 1,4-diazaphenanthrene derivatives

  摘要：

  9- and 10-membered macrolactones bearing benzo and diazine rings were obtained by chemoselective ozonolysis of dihydrofuran and pyran 1,4-diazaphenathrene derivatives. This is the first example of preparation of macrolactones by chemoselective ozonolysis of an enol double bond shared by aromatic and heterocyclic rings. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.10.075

文献信息

• Synthesis of 9- and 10-membered macrolactones by selective ozonolysis of 1,4-diazaphenanthrene derivatives
  作者：Elisa Pérez-Sacau、Jorge Soto-Delgado、Ana Estévez-Braun、Ángel G. Ravelo

  DOI：10.1016/j.tet.2004.10.075

  日期：2005.1

  9- and 10-membered macrolactones bearing benzo and diazine rings were obtained by chemoselective ozonolysis of dihydrofuran and pyran 1,4-diazaphenathrene derivatives. This is the first example of preparation of macrolactones by chemoselective ozonolysis of an enol double bond shared by aromatic and heterocyclic rings. (C) 2004 Elsevier Ltd. All rights reserved.