D-甘油-D-酸根-七酸,δ-内酯 | 98517-62-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: D-甘油-D-酸根-七酸,δ-内酯
• 英文名称: Glucuronate 2-sulfate
• 英文别名: (2S,3S,4S,5R)-2,3,4-trihydroxy-6-oxo-5-sulfooxyhexanoic acid
• CAS: 98517-62-5
• 化学式: C₆H₁₀O₁₀S
• 分子量: 274.2
• InChiKey: PURMPUDWXOWORS-QTBDOELSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  187
• 氢给体数：
  5
• 氢受体数：
  10

文献信息

• Carbohydrate epitope mimic compounds and uses thereof
  申请人：——

  公开号：US20030100508A1

  公开（公告）日：2003-05-29

  This invention provides carbohydrate epitope mimic compounds, particularly peptides, and analogs and variants thereof. In particular, the compounds and peptides of the present invention mimic the carbohydrate epitope GlcA&bgr;1→3Gal&bgr;1→4GlcNAc or sulfate -3GlcA&bgr;1→3Gal&bgr;1→4GlcNAc, or the L2/HNK1 carbohydrate epitope. This invention provides an isolated peptide comprising an amino acid sequence of a carbohydrate epitope mimic peptide in which the amino acid sequence is set forth in any of SEQ ID NOS: 1-8, 27-38, 39, 40 and 41, including variants, analogs and active fragments thereof. The invention further provides an isolated nucleic acid encoding a peptide comprising an amino acid sequence of a carbohydrate epitope mimic peptide. This invention provides pharmaceutical compositions and diagnostic and therapeutic methods of use of the isolated polypeptides and nucleic acids, particularly in modulating or mediating cell-cell adhesion and viral infection and the processes and events mediated thereby. Assays for compounds which mimic, alter or inactivate the polypeptides of the present invention for use in therapy are also provided.

  这项发明提供了碳水化合物表位模拟化合物，特别是肽，以及其类似物和变体。具体地，本发明的化合物和肽模拟了碳水化合物表位GlcA&bgr;1→3Gal&bgr;1→4GlcNAc或硫酸酯-3GlcA&bgr;1→3Gal&bgr;1→4GlcNAc，或L2/HNK1碳水化合物表位。这项发明提供了一种包含碳水化合物表位模拟肽的氨基酸序列的孤立肽，其中氨基酸序列在任何SEQ ID NOS: 1-8、27-38、39、40和41中规定，包括其变体、类似物和活性片段。该发明还提供了编码包含碳水化合物表位模拟肽氨基酸序列的肽的孤立核酸。这项发明提供了药物组合物和使用孤立多肽和核酸的诊断和治疗方法，特别是在调节或介导细胞间黏附和病毒感染以及由此介导的过程和事件中。还提供了用于治疗的模拟、改变或使本发明的多肽失活的化合物的测定方法。
• MULTIVALENT ANTIVIRAL COMPOSITIONS, METHODS OF MAKING, AND USES THEREOF
  申请人：The Charles Stark Draper Laboratory, Inc.

  公开号：US20150158956A1

  公开（公告）日：2015-06-11

  This disclosure provides compositions, kits, and methods useful for treating or preventing viral infection. The methods comprise administering to a subject an effective amount of a sulfated polysaccharide composition.

  本披露提供了用于治疗或预防病毒感染的组合物、试剂盒和方法。该方法包括向受试者施用有效量的磺化多糖组合物。
• Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
  申请人：Pecquet Christelle

  公开号：US20050171055A1

  公开（公告）日：2005-08-04

  Alkali and alkali-earth metal salts of polysaccharides derived from heparin, their method of preparation and the pharmaceutical compositions containing them.

  碱和碱土金属盐的多糖衍生物来源于肝素，其制备方法和含有它们的制药组合物。
• COMPOSITIONS AND IMPROVED SOFT TISSUE REPLACEMENT METHODS
  申请人：Van Epps Dennis E.

  公开号：US20120189590A1

  公开（公告）日：2012-07-26

  The specification discloses compositions and methods for treating a soft tissue defect of an individual.

  该规范公开了用于治疗个体软组织缺陷的组合物和方法。
• METHODS OF TREATING SOFT TISSUE DEFECTS
  申请人：Allergan, Inc.

  公开号：US20140179752A1

  公开（公告）日：2014-06-26

  The specification discloses compositions and methods for treating a soft tissue defect of an individual.

  该规范公开了治疗个体软组织缺陷的组成物和方法。