n-heptylmalonyl chloride | 76461-96-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: n-heptylmalonyl chloride
• 英文别名: 2-Heptylpropanedioyl dichloride
• CAS: 76461-96-6
• 化学式: C₁₀H₁₆Cl₂O₂
• 分子量: 239.142
• InChiKey: OBLJBHOUSFRBLO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  14
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  羟丙基淀粉磷酸酯 、 n-heptylmalonyl chloride 以 苯 为溶剂， 反应 48.0h， 以35%的产率得到18-n-heptyl-1,4,7,10,13,16-hexaoxacyclononadecane-17,19-dione
  参考文献：
  名称：

  Bradshaw, Jerald S.; Jolley, Scott T.; Jones, Brian A., Journal of Heterocyclic Chemistry, 1980, vol. 17, # 9, p. 1317 - 1318

  摘要：

  DOI：

文献信息

• BRADSHAW J. S.; JOLLEY S. T.; JONES B. A., J. HETEROCYCL. CHEM., 1980, 17, NO 6, 1317-1318
  作者：BRADSHAW J. S.、 JOLLEY S. T.、 JONES B. A.

  DOI：——

  日期：——
• PHOSPHODIESTERASE-V MODULATOR DRUGS AND THEIR USES
  申请人：Advanced Medicine, Inc.

  公开号：EP1085893A1

  公开（公告）日：2001-03-28
• Block Copolymers As Thermoplastic Elastomers Made Of Polyisobutene Blocks And Oligoamide Blocks
  申请人：König Hannah Maria

  公开号：US20120271003A1

  公开（公告）日：2012-10-25

  Aspects of the invention relate to block copolymers having the properties of thermoplastic elastomers made of blocks on the basis of isobutene monomer units as the soft segment and blocks on the basis of oligoamides composed of at least two base units, each of which comprises an amino or a carbonyl group in the α, β, γ or δ position to each other or directly bound to each other, as the hard segment. Such block copolymers are suited for producing fibers, microfibers, and films.
• US4388246A
  申请人：——

  公开号：US4388246A

  公开（公告）日：1983-06-14
• [EN] PHOSPHODIESTERASE-V MODULATOR DRUGS AND THEIR USES<br/>[FR] MEDICAMENTS MODULATEURS DE LA PHOSPHODIESTERASE-5 ET LEURS UTILISATIONS
  申请人：ADVANCED MEDICINE INC

  公开号：WO1999064033A1

  公开（公告）日：1999-12-16

  This invention relates to novel multibinding compounds that bind to the enzyme phosphodiesterase V (PDE V) and modulate its activity. The compounds of this invention comprise 2-10 PDE V modulator (particularly inhibitor) ligands covalently connected by a linker or linkers, wherein the ligands in their monovalent (i.e., unlinked) state bind to a PDE V enzyme. The manner of linking the ligands together is such that the multibinding agents thus formed demonstrate an increased biologic and/or therapeutic effect as compared to the same number of unlinked ligands made available for binding to PDE V. The invention also relates to methods of using such compounds and to methods of preparing them. The compounds of this invention are particularly useful for treating diseases and conditions of mammals that are mediated by PDE V. Accordingly, this invention also relates to pharmaceutical compositions comprising a pharmaceutically acceptable excipient and an effective amount of a compound of this invention.