2-Hydrazino-3-(4-hydroxphenyl)-propionsaeure | 5060-36-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Hydrazino-3-(4-hydroxphenyl)-propionsaeure
• 英文别名: DL-2-Hydrazino-3-(4-hydroxyphenyl)propionic acid；aminotyrosine；alpha-Hydrazinophloretic acid；2-hydrazinyl-3-(4-hydroxyphenyl)propanoic acid
• CAS: 5060-36-6
• 化学式: C₉H₁₂N₂O₃
• mdl: MFCD00798976
• 分子量: 196.206
• InChiKey: XJPHGGXFBWOHFL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  95.6
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  methyl 2-diazo-3-(4-hydroxyphenyl)propanoate 在 sodium amalgam 作用下， 以 乙醇 为溶剂， 生成 2-Hydrazino-3-(4-hydroxphenyl)-propionsaeure
  参考文献：
  名称：

  Amino acids and peptides. XX. Reduction of .ALPHA.-substituted .ALPHA.-diazo esters. Convenient synthesis of .ALPHA.-hydrazinocarboxylic acids and their derivatives from .ALPHA.-amino acids.

  摘要：

  α-取代的α-重氮酯（I）可通过α-氨基酸酯制备，并用各种还原剂还原得到相应的α-肼基羧酸（II）及其衍生物。此外，还进行了多项研究，以从I合成α, α-二取代的α-肼基羧酸衍生物（VII）。

  DOI：

  10.1248/cpb.24.800

文献信息

• Chemoselective Rapid Azo-Coupling Reaction for Bioconjugation
  申请人：Trustees of Boston College

  公开号：US20180360984A1

  公开（公告）日：2018-12-20

  Novel biomolecular conjugates containing non-natural aromatic chemical moieties covalently coupled to a diazonium compound and methods of their use are disclosed.

  揭示了含有非天然芳香化学基团的新型生物分子共轭物，其与重氮化合物共价耦合，并公开了它们的使用方法。
• AMINO ACID DERIVATIVES AND ABSORBABLE POLYMERS THEREFROM
  申请人：Bezwada Biomedical, LLC

  公开号：US20160257643A1

  公开（公告）日：2016-09-08

  The present invention relates to the discovery of new class of hydrolysable amino acid derivatives and absorbable polyester amides, polyamides, polyepoxides, polyureas and polyurethanes prepared therefrom. The resultant absorbable polymers are useful for drug delivery, tissue engineering, tissue adhesives, adhesion prevention, bone wax formulations, medical device coatings, stents, stent coatings, highly porous foams, reticulated foams, wound care, cardiovascular applications, orthopedic devices, surface modifying agents and other implantable medical devices. In addition, these absorbable polymers should have a controlled degradation profile.

  本发明涉及发现一类新的可水解氨基酸衍生物和可吸收聚酯酰胺、聚酰胺、聚环氧化物、聚脲和由此制备的聚氨酯。由此产生的可吸收聚合物可用于药物输送、组织工程、组织粘合剂、粘附防止、骨蜡配方、医疗器械涂层、支架、支架涂层、高度多孔泡沫、网状泡沫、伤口护理、心血管应用、骨科器械、表面改性剂和其他可植入医疗器械。此外，这些可吸收聚合物应具有受控的降解特性。
• AMINO ACID DERIVATIVES AND ABSORABLE POLYMERS THEREFROM
  申请人：Bezwada Rao S.

  公开号：US20120208896A1

  公开（公告）日：2012-08-16

  The present invention relates to the discovery of new class of hydrolysable amino acid derivatives and absorbable polyester amides, polyamides, polyepoxides, polyureas and polyurethanes prepared therefrom. The resultant absorbable polymers are useful for drug delivery, tissue engineering, tissue adhesives, adhesion prevention, bone wax formulations, medical device coatings, stents, stent coatings, highly porous foams, reticulated foams, wound care, cardiovascular applications, orthopedic devices, surface modifying agents and other implantable medical devices. In addition, these absorbable polymers should have a controlled degradation profile.

  本发明涉及一种新类水解性氨基酸衍生物和可吸收聚酯酰胺、聚酰胺、聚环氧化物、聚脲和由此制备的聚氨酯。所得的可吸收聚合物可用于药物输送、组织工程、组织粘合剂、粘附预防、骨蜡配方、医疗器械涂层、支架、支架涂层、高度多孔泡沫、网状泡沫、伤口护理、心血管应用、骨科器械、表面改性剂和其他可植入医疗器械。此外，这些可吸收聚合物应具有受控降解特性。
• [EN] AFMT ANALOGS AND THEIR USE IN METHODS OF TREATING PARKINSON'S DISEASE<br/>[FR] ANALOGUES DE L'AFMT ET LEUR UTILISATION DANS DES MÉTHODES DE TRAITEMENT DE LA MALADIE DE PARKINSON
  申请人：HARVARD COLLEGE

  公开号：WO2021216781A1

  公开（公告）日：2021-10-28

  The present disclosure provides compounds of formula (I), (II), and (la): Methods of preparing these molecules and their use for treatment of Parkinson's Disease are described.

  本公开提供了式(I)、(II)和(la)的化合物：描述了制备这些分子的方法以及它们用于治疗帕金森病的用途。
• DIPEPTIDE LINKED MEDICINAL AGENTS
  申请人：Indiana University Research and Technology Corporation

  公开号：US20160158375A1

  公开（公告）日：2016-06-09

  A non-enzymatically self cleaving dipeptide element is provided that can be linked to known medicinal agents via an amide bond. The dipeptide will spontaneously be cleaved from the medicinal agent under physiological conditions through a reaction driven by chemical instability. Accordingly, the dipeptide element provides a means of linking various compounds to known medicinal agents wherein the compounds are subsequently released from the medicinal agent after a predetermined time of exposure to physiological conditions. For example, the dipeptide can be linked to an active site of a drug to form a prodrug and/or the dipeptide may comprise a depot polymer to sequester an injectable composition comprising the complex at the point of administration.

  提供了一种非酶自裂二肽元素，可通过酰胺键与已知药物剂量连接。在生理条件下，由于化学不稳定性驱动的反应，二肽将自发地从药物剂量中裂解。因此，二肽元素提供了一种将各种化合物链接到已知药物剂量的手段，其中化合物在暴露于生理条件一定时间后随后从药物剂量中释放出来。例如，二肽可以与药物的活性位点连接以形成前药，或二肽可以包含一个沉淀聚合物，以将包含复合物的注射剂量隔离在给药点处。