propyl glyoxylate propyl hemiacetal | 90883-51-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: propyl glyoxylate propyl hemiacetal
• 英文别名: glyoxylic acid propyl ester propyl hemiacetal；Propyl 2-hydroxy-2-propoxyacetate
• CAS: 90883-51-5
• 化学式: C₈H₁₆O₄
• 分子量: 176.213
• InChiKey: DVTFPJRIOQGSEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  propyl glyoxylate propyl hemiacetal 、 丙烯酰胺 以 丙醇 、 硫酸 为溶剂， 生成 propyl acrylamidoglycolate propyl ether 、 甲苯
  参考文献：
  名称：

  Preparation of predominately methyl acrylamidoglycolate methyl ether in

  摘要：

  使用C.sub.3到C.sub.6醇与甘醇酸反应，形成C.sub.3到C.sub.6烷基甘酸酯或烷基甘酸酯烷基半缩醛，然后将中间体与丙烯酰胺反应，可选地使用C.sub.3到C.sub.6醇，形成基本无聚合物的C.sub.3到C.sub.6烷基丙烯酰胺甘酸酯或烷基丙烯酰胺甘酸酯烷基醚，可通过与甲醇的转酯化/醚化或转酯化/转醚化反应，轻松地转化为主要为液态的甲基丙烯酰胺甘酸酯甲醚。

  公开号：

  US04443623A1

文献信息

• Optically active or racemic aminal derivatives, process for preparing same and for converting same to alpha-hydroxyaldehydes
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0011417A1

  公开（公告）日：1980-05-28

  An optically active or racemic a-hydroxyaldehyde of formula wherein R, represents a C6-C14 aryl group, C1-C10 alkyl group, C1-C10 alkenyl group, C2-C10 alkynyl group, C2-C14 aralkyl group, or a group containing a functional group in the organic portion of said groups and R: represents a C1-C10 alkyl group, C1-C10 alkenyl group, C1-C10 alkynyl group, C7-C14 aralkyl group, C6-C14 aryl group or a group containing a functional group in the organic portion of these groups, which is an important intermediate for preparation of pharmaceuticals and agricultural chemicals and can be prepared by reacting an optically active or racemic compound of formula wherein A represents a C6-C14 aryl group or a C1-C4 alkyl or alkoxy group- or halogen-substituted C6-C14 aryl group and R is as defined above, with a Grignard reagent, and thereafter hydrolyzing the reaction product. The compound of formula (1) above can for example be prepared by reaction of an arylglyoxal with an optically active or racemic 2-iN-substituted aminomethyl)pyrroiidine or by reacting a Grignard reagent with an optically active or racemic. diazabicyclooctane derivative which itself can be prepared from a glyoxylate ester or glyoxylate ester hemiacetal and a 2(-N-substituted aminomethyl)pyrrolidine.

  式中具有光学活性或外消旋的 a-羟基醛 其中 R 代表 C6-C14 芳基、C1-C10 烷基、C1-C10 烯基、C2-C10 炔基、C2-C14 芳烷基或在上述基团的有机部分含有官能团的基团，R：代表 C1-C10 烷基、C1-C10 烯基、C1-C10 炔基、C7-C14 芳基、C6-C14 芳基或在这些基团的有机部分含有官能团的基团。 其中 A 代表 C6-C14 芳基或 C1-C4 烷基或烷氧基或卤素取代的 C6-C14 芳基，R 如上定义，与格氏试剂反应，然后水解反应产物。 例如，上述式（1）化合物可通过芳基乙二醛与光学活性的或外消旋的 2-(-N-取代氨甲基)吡咯烷反应制备，或通过格氏试剂与光学活性的或外消旋的二氮杂双环辛烷衍生物反应制备，二氮杂双环辛烷衍生物本身可由乙醛酸酯或乙醛酸酯半缩醛和 2-(-N-取代氨甲基)吡咯烷制备。
• Optically active or racemic diazabicyclooctane derivatives
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0048501A1

  公开（公告）日：1982-03-31

  Optically active or racemic diazabicyclooctane derivatives of formula wherein A represents a C6-C14 aryl group or a C1-C4 alkyl or alkoxy group- or halogen-substituted C6-C14 aryl group and R3 represents a C1-C4 alkyl group. These compounds can be prepared by reacting a glyoxylate ester or glyoxylate ester hemiacetal with a 2(-N-substituted aminomethyl)pyrrolidine, and can be used to prepare optically active and racemic α-hydroxyaldehydes which are important intermediates in the preparation of pharmaceuticals and agricultural chemicals.

  式中 A 代表 C6-C14 芳基或 C1-C4 烷基或烷氧基或卤素取代的 C6-C14 芳基，R3 代表 C1-C4 烷基的具有光学活性或外消旋的二氮杂双环辛烷衍生物。 这些化合物可通过乙醛酸酯或乙醛酸酯半缩醛与 2(-N-取代的氨基甲基)吡咯烷反应制备，并可用于制备具有光学活性和外消旋的 α-羟基醛，它们是制备药物和农药的重要中间体。
• Verfahren zur Herstellung von 5-Arylhydantoinen
  申请人：Chemie Linz GmbH

  公开号：EP0599198A1

  公开（公告）日：1994-06-01

  Verfahren zur Herstellung von 5-Arylhydantoinen durch Umsetzung von Allantoinsäurealkylester mit einer Arylverbindung in konzentrierter anorganischer Säure bei Temperaturen von Raumtemperatur bis 150 °C mit oder ohne einen Phasenvermittler.

  通过尿囊酸烷基酯与芳基化合物在室温至 150°C 的浓无机酸中反应制备 5-芳基海因的工艺，可使用或不使用相介质。
• Propylene ureas and the process for their preparation
  申请人：DAINIPPON INK AND CHEMICALS, INC.

  公开号：EP0976738A2

  公开（公告）日：2000-02-02

  New urea derivatives, a process for their preparation and their use for the hardening of hydroxyl group-containing polymers are described. The urea derivatives according to the invention have the general formula 1 in which R1-R7 represent a hydrogen atom or a linear or branched C1-C4-alkyl group, preferably methyl, ethyl, n-propyl, isopropyl, n-butyl or isobutyl group, wherein R1-R7 may be identical or different, and R8 represents a linear or branched C1-C6-alkyl group, preferably a methyl, ethyl, n-propyl, isopropyl, n-butyl or isobutyl group. The urea derivatives of the general formula 1 according to the invention are prepared by reacting a compound of the general formula 2 in which R9 represents a unit from the group -CHO, -CH(OH)-OR8 and -CH(OH)2 and R8 is defined as above, with a urea derivative of the general formula 3 in which R1-R6 are defined as above and optionally followed by etherification of the reaction product obtained with an alcohol of the general formula X-OH, in which X represents a linear or branched C1-C4-alkyl group. The urea derivatives according to the invention contain no oligomeric fractions and they are extremely suitable for hardening hydroxyl group-containing polymers. They are superior to the reaction products of ethylene ureas and dioxylate derivatives known from the prior art.

  本发明描述了新的脲衍生物、其制备工艺及其在硬化含羟基聚合物中的用途。 根据本发明的脲衍生物具有通式 1 其中 R1-R7 代表氢原子或直链或支链 C1-C4 烷基，最好是甲基、乙基、正丙基、异丙基、正丁基或异丁基，其中 R1-R7 可以相同或不同，R8 代表直链或支链 C1-C6 烷基，最好是甲基、乙基、正丙基、异丙基、正丁基或异丁基。 根据本发明，通式 1 的脲衍生物是通过与通式 2 的化合物反应制备的。 其中 R9 代表-CHO、-CH(OH)-OR8 和-CH(OH)2 组中的一个单元，R8 定义同上，与通式 3 的脲衍生物反应 其中 R1-R6 定义同上，然后将反应产物与通式 X-OH 的醇进行醚化，其中 X 代表直链或支链 C1-C4 烷基。 本发明的脲衍生物不含低聚物，非常适用于硬化含羟基的聚合物。它们优于现有技术中已知的乙烯脲和二恶英衍生物的反应产物。
• PROPYLENE UREAS AND PROCESS FOR THEIR PREPARATION.
  申请人：——

  公开号：US20020004599A1

  公开（公告）日：2002-01-10

  Urea derivatives of formula 1 for the hardening of hydroxyl group-containing polymers. 1 wherein each of R 1 -R 7 is a hydrogen atom or a linear or branched C 1 -C 4 -alkyl group, preferably methyl, ethyl, n-propyl, isopropyl, n-butyl or isobutyl, R 1 -R 7 being identical or different, and R 8 is a linear or branched C 1 -C 6 -alkyl group, preferably methyl, ethyl, n-propyl, isopropyl, n-butyl or isobutyl. The compounds 1 are prepared by reacting a compound 2 2 wherein R 9 is a member selected from the group consisting of —CHO, —CH(OH) —OR 8 and —CH(OH) 2 with a urea derivative 3 3 optionally followed by etherification of the reaction product with an alcohol X—OH, wherein X is a linear or branched C 1 -C 4 -alkyl group.

  用于硬化含羟基聚合物的式 1 尿素衍生物。 1 其中每个 R 1 -R 7 是氢原子或线性或支链 C 1 -C 4 -烷基，最好是甲基、乙基、正丙基、异丙基、正丁基或异丁基，R 1 -R 7 相同或不同，而 R 8 是线性或支链 C 1 -C 6 -烷基，最好是甲基、乙基、正丙基、异丙基、正丁基或异丁基。 化合物 1 是通过以下反应制备的 2 2 其中 R 9 是选自-CHO、-CH(OH) -OR 8 和-CH(OH) 2 与脲衍生物 3 3 然后用醇 X-OH 将反应产物醚化，其中 X 是线性或支链 C 1 -C 4 -烷基。