2-(4-fluorophenyl)-3-[[2-(4-fluorophenyl)-1H-indol-3-yl]-(4-methoxyphenyl)methyl]-1H-indole | 1211973-79-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-(4-fluorophenyl)-3-[[2-(4-fluorophenyl)-1H-indol-3-yl]-(4-methoxyphenyl)methyl]-1H-indole
• CAS: 1211973-79-3
• 化学式: C₃₆H₂₆F₂N₂O
• 分子量: 540.612
• InChiKey: OAIJDXFDIMDUJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9
• 重原子数：
  41
• 可旋转键数：
  6
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  40.8
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-甲氧基苯甲醛 、 2-(4-氟苯基)吲哚 在 溶剂黄146 作用下， 反应 0.1h， 以83%的产率得到2-(4-fluorophenyl)-3-[[2-(4-fluorophenyl)-1H-indol-3-yl]-(4-methoxyphenyl)methyl]-1H-indole
  参考文献：
  名称：

  Green Protocol for the Synthesis of Bisindolylmethanes and Evaluation of Their Antimicrobial Activities

  摘要：

  A simple, efficient, and ecofriendly procedure for the preparation of bis(indolyl) methanes via electrophilic substitution reactions of 2-phenylindoles with aldehydes is described. The reaction takes place in the presence of glacial acetic acid and a catalytic amount of anhydrous ferric chloride. All the synthesized compounds have been characterized by elemental analysis and spectral data (IR and H-1 NMR). They have also been evaluated for their antibacterial and antifungal activities, and some of them have shown promising results against S. aureus, E. coli, A. flavus, and A. niger.

  DOI：

  10.1080/10426500802590178

文献信息

• Green Protocol for the Synthesis of Bisindolylmethanes and Evaluation of Their Antimicrobial Activities
  作者：Anjali Tiwari、Meenakshi Jain

  DOI：10.1080/10426500802590178

  日期：2009.10.30

  A simple, efficient, and ecofriendly procedure for the preparation of bis(indolyl) methanes via electrophilic substitution reactions of 2-phenylindoles with aldehydes is described. The reaction takes place in the presence of glacial acetic acid and a catalytic amount of anhydrous ferric chloride. All the synthesized compounds have been characterized by elemental analysis and spectral data (IR and H-1 NMR). They have also been evaluated for their antibacterial and antifungal activities, and some of them have shown promising results against S. aureus, E. coli, A. flavus, and A. niger.