(1,3-dioxolan-4-yl)methylamine | 4388-99-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氧戊环
• 英文名称: (1,3-dioxolan-4-yl)methylamine
• 英文别名: (1,3-Dioxolan-4-yl)methanamine；1,3-dioxolan-4-ylmethanamine
• CAS: 4388-99-2
• 化学式: C₄H₉NO₂
• 分子量: 103.121
• InChiKey: NJYBVFSXBDLXHH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  7
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  44.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (1,3-dioxolan-4-yl)methylamine 、 3-Methyl-1H-pyrrole-2,4-dicarboxylic acid 2-pentafluorophenyl ester 4-(1,2,2-trimethyl-propyl) ester 在 TEA 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 生成 5-[([1,3]Dioxolan-4-ylmethyl)-carbamoyl]-4-methyl-1H-pyrrole-3-carboxylic acid 1,2,2-trimethyl-propyl ester
  参考文献：
  名称：

  3-Methyl pyrrole-2,4-dicarboxylic acid 2-propyl ester 4-(1,2,2-trimethyl-propyl) ester: an exploration of the C-2 position. Part I

  摘要：

  Following the recent disclosure of 3-methyl pyrrole-2,4-dicarboxylic acid 2-propyl ester 4-(1,2,2-trimethyl-propyl) ester, a potent and selective mGluR1 non-competitive antagonist, we report here a detailed exploration of the C-2 position of this scaffold with the preparation of differently substituted amides. Great improvement of the pharmacokinetic properties has been achieved through this exercise.

  DOI：

  10.1016/j.farmac.2003.12.005
• 作为产物：
  描述：

  4-chloromethyl-[1,3]dioxolane 在 二环己烷并-18-冠醚-6 、 氨 作用下， 反应 12.0h， 以55%的产率得到(1,3-dioxolan-4-yl)methylamine
  参考文献：
  名称：

  Zlotskij, S. S.; Rol'nik, L. S.; Kabibulin, I. R., Journal fur praktische Chemie (Leipzig 1954), 1991, vol. 333, # 1, p. 139 - 143

  摘要：

  DOI：

文献信息

• METHOD FOR CONTROLLING ARTHROPOD PEST
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20150344466A1

  公开（公告）日：2015-12-03

  An amide compound represented by formula (I): [wherein A represents a 3- to 7-membered saturated heterocyclic ring which contains, as ring-forming component(s), one or more atoms or groups selected from the group consisting of an oxygen atom and —S(O) t —, t represents 0, etc., R 1 and R 2 are the same or different and represent a hydrogen atom, etc., n represents 0, etc., the following formula (II): represents a 5-membered aromatic ring, in which Z represents a nitrogen atom or a carbon atom and X 1 , X 2 and X 3 are the same or different and represent a nitrogen atom, etc., R 3 and R 4 are the same or different and represent a hydrogen atom, etc., m represents 0 to 2, Q represents one group selected from group A or a C1 to C8 chain hydrocarbon group optionally having one group selected from group A, Y represents an oxygen atom, etc., u represents 0, etc., and v represents 0, etc.] has excellent arthropod pest controlling effects.

  化合物式(I)所代表的酰胺化合物：[其中A代表一个3到7个成员的饱和杂环环，该环包含作为环构成组分之一或多个原子或基团，所选自氧原子和—S（O）t—群，t代表0等；R1和R2相同或不同，代表氢原子等；n代表0等；下列式子(II)代表一个5个成员的芳香环，在该环中Z代表一个氮原子或一个碳原子，X1、X2和X3相同或不同，代表氮原子等，R3和R4相同或不同，代表氢原子等，m代表0到2，Q代表从群A中选择的一个群或一个C1到C8链烃基团，该基团可以选择从群A中选择的一个群，Y代表氧原子等，u代表0等，v代表0等]具有优良的节肢动物害虫控制效果。
• Amide compound, an arthropod pest control agent and a method for controlling arthropod pest
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP2952096B1

  公开（公告）日：2018-04-04
• JP2015/51963
  申请人：——

  公开号：——

  公开（公告）日：——
• 3-Methyl pyrrole-2,4-dicarboxylic acid 2-propyl ester 4-(1,2,2-trimethyl-propyl) ester: an exploration of the C-2 position. Part I
  作者：Fabrizio Micheli、Romano Di Fabio、Roberto Benedetti、Anna Maria Capelli、Palmina Cavallini、Paolo Cavanni、Silvia Davalli、Daniele Donati、Aldo Feriani、Sylvie Gehanne、Mahmoud Hamdan、Micaela Maffeis、Fabio Maria Sabbatini、Maria Elvira Tranquillini、Monica Valeria Angela Viziano

  DOI：10.1016/j.farmac.2003.12.005

  日期：2004.3

  Following the recent disclosure of 3-methyl pyrrole-2,4-dicarboxylic acid 2-propyl ester 4-(1,2,2-trimethyl-propyl) ester, a potent and selective mGluR1 non-competitive antagonist, we report here a detailed exploration of the C-2 position of this scaffold with the preparation of differently substituted amides. Great improvement of the pharmacokinetic properties has been achieved through this exercise.
• Cyclic amino-acetals
  申请人：CIBA LTD

  公开号：US02513747A1

  公开（公告）日：1950-07-04