benzyl N-[2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]carbamate | 7474-40-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: benzyl N-[2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]carbamate
• CAS: 7474-40-0
• 化学式: C₁₄H₁₉NO₇
• 分子量: 313.3
• InChiKey: FRTOTMQAWIIMKK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  129
• 氢给体数：
  5
• 氢受体数：
  7

文献信息

• Hydrolysis resistant sialic acid derivatives and methods for their use
  申请人：The University of British Columbia

  公开号：US10023601B2

  公开（公告）日：2018-07-17

  This invention provides compound having a structure of Formulas: Furthermore, methods and uses of such compounds for covalently bonding to a sugar acceptor, to form modified protein therapeutics having reduced enzymatic hydrolysis, improved biological stability or an improved pharmacokinetic property.

  本发明提供具有式结构的化合物：此外，还提供了此类化合物与糖受体共价键合的方法和用途，以形成具有减少酶水解、提高生物稳定性或改善药代动力学特性的改性蛋白质治疗剂。
• Hydrolysis Resistant Sialic Acid Derivatives and Methods for Their Use
  申请人：The University of British Columbia

  公开号：US20170121361A1

  公开（公告）日：2017-05-04

  This invention provides compound having a structure of Formulas: Furthermore, methods and uses of such compounds for covalently bonding to a sugar acceptor, to form modified protein therapeutics having reduced enzymatic hydrolysis, improved biological stability or an improved pharmacokinetic property.
• US9956240B2
  申请人：——

  公开号：US9956240B2

  公开（公告）日：2018-05-01