Galili抗原五糖 | 62258-12-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: Galili抗原五糖
• 中文别名: 乳-N-双岩藻糖六糖II；Lewis-b(Le-b)五糖；Lewis-a六糖；乳糖-N-双岩藻六糖II；乳糖-N-二氟六糖II
• 英文名称: Lacto-N-difucohexose II
• 英文别名: N-[(2S,3R,4R,5S,6R)-2-[(2R,3S,4S,5R,6S)-3,5-dihydroxy-2-(hydroxymethyl)-6-[(2R,3R,4R,5R)-1,2,5-trihydroxy-6-oxo-4-[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyhexan-3-yl]oxyoxan-4-yl]oxy-6-(hydroxymethyl)-4-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5-[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl]acetamide
• CAS: 62258-12-2
• 化学式: C₃₈H₆₅NO₂₉
• 分子量: 999.9
• InChiKey: QNSWVQWPVUZACH-XCVMNONQSA-N

物化性质

• 沸点：
  1366.0±65.0 °C(Predicted)
• 密度：
  1.71±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -11
• 重原子数：
  68
• 可旋转键数：
  19
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  482
• 氢给体数：
  18
• 氢受体数：
  29

文献信息

• [EN] COMPOSITIONS COMPRISING ONE OR MORE HMO'S WITH A CORE OF LacNAc-Lac<br/>[FR] COMPOSITIONS COMPRENANT UN OU PLUSIEURS OLH AYANT UN SQUELETTE DE LACNAC-LAC
  申请人：FRIESLANDCAMPINA NEDERLAND BV

  公开号：WO2021191251A1

  公开（公告）日：2021-09-30

  A synthetic composition comprising one or more compounds according to formula (1), or a pharmaceutically acceptable salt, solvate or ester thereof, for use in the modulation of one or more of: i. the cholesterol level; ii. lipolysis; iii. glucose uptake; iv. CD36 receptor activity; wherein the compound of Formula 1 is Yn→D-Gal-β1→3-(Ym→)(Xp→)D-GlcNAc-β1→3-D-Gal-β1→4-(Xq→)-D-Glc (Formula (1)), wherein X is α-L-Fucose (α-L-Fuc), Y is N-acetyl-D-neuraminic acid (Neu5Ac-α-2-), n, m, p, q indicate the number of the monosaccharide residues present in the compound of formula (1) and n is 0 or 1; m is 0 or 1; p is 0 or 1; q is 0 or 1; and n+m+p+q ≥ 1.