histidylglycine | 2578-58-7

• 物质功能分类: 生物 - 细胞培养 - 添加剂
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: histidylglycine
• 英文别名: Histidyl-glycin；2-[[2-azaniumyl-3-(1H-imidazol-5-yl)propanoyl]amino]acetate
• CAS: 2578-58-7
• 化学式: C₈H₁₂N₄O₃
• 分子量: 212.208
• InChiKey: LYCVKHSJGDMDLM-UHFFFAOYSA-N

物化性质

• 熔点：
  180-182℃
• 沸点：
  687.4±55.0 °C(Predicted)
• 密度：
  1.434±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -3.9
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  121
• 氢给体数：
  4
• 氢受体数：
  5

安全信息

• WGK Germany：
  3
• 海关编码：
  2933290090

反应信息

• 作为反应物：
  描述：

  histidylglycine 、 [ReOCl3(OPPh3)(SMe2)] 、 苯 以 乙腈 为溶剂， 以51%的产率得到
  参考文献：
  名称：

  Binding of the Oxo−Rhenium(V) Core to Methionine and to N-Terminal Histidine Dipeptides

  摘要：

  The ReOX2(met) compounds (X = Cl, Br) adopt a distorted octahedral structure in which a carboxylato oxygen lies trans to the Re=O bond, whereas the equatorial plane is occupied by two cis halides, an NH2, and an SCH3 group. Coordination of the SCH3 unit creates an asymmetric center, leading to two diastereoisomers. X-ray diffraction studies reveal that the crystals of ReOBr2(D,L-met)(.)1/2H(2)O and ReOBr2(D,L-met)(.)1/2CH(3)OH contain only the syn isomer (S-CH3 bond on the side of the Re=O bond), whereas ReOCl2(D-met) and ReOCl2(D,L-met) consist of the pure anti isomer. H-1 NMR spectroscopy shows that both isomers coexist in equilibrium in acetone (anti/syn ratio = 1:1 for X = Br, 3:1 for X = Cl). Exchange between these two isomers is fast above room temperature, but it slows down below 0degreesC, and the sharp second-order spectra of both isomers at -20degreesC were fully assigned. The coupling constants are consistent with the solid-state conformations being retained in solution. Complexes of the type [ReOX2(His-aa)]X (X = Cl, Br) are isolated with the dipeptides His-aa (aa = Gly, Ala, Leu, and Phe). X-ray diffraction work on [ReOBr2(His-Ala)]Br reveals the presence of distorted octahedral cations containing the Re= O3+ core and a dipeptide coordinated through the histidine residue via the imidazole nitrogen, the terminal amino group, and the amide oxygen, the site trans to the Re=O bond being occupied by the oxygen. The alanine residue is ended by a protonated carboxylic group that does not participate in the coordination. The constant pattern of the H-1 NMR signals for the protons in the histidine residue confirms that the various dipeptides adopt a similar binding mode, consistent with the solid-state structure being retained in CD3OD solution.

  DOI：

  10.1021/ic048776e
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 盐酸 作用下， 生成 histidylglycine
  参考文献：
  名称：

  Bergmann; Zervas, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1928, vol. 175, p. 150

  摘要：

  DOI：

文献信息

• Control of pH in aqueous urea-containing solutions utilizing amino acid-containing compositions
  申请人：Siemens Healthcare Diagnostics Inc.

  公开号：US10073104B2

  公开（公告）日：2018-09-11

  Aqueous calibration or quality control reagents that include urea are disclosed; the reagents may further include at least one amino acid-containing composition to provide pH stability thereto. Methods of production and use thereof are also disclosed.

  公开了包括尿素的水性校准或质量控制试剂；这些试剂可进一步包括至少一种含氨基酸的成分，以提供其 pH 值稳定性。还公开了其生产和使用方法。
• Method for pH-biased isoelectric trapping separation
  申请人：Gradipore Limited

  公开号：US20030226752A1

  公开（公告）日：2003-12-11

  A method for altering the initial composition of an ampholytic component containing sample by isoelectric trapping provides for selecting a first isoelectric buffer having a pI value different from the pI value of a first ampholytic sample component in the sample, contacting the isoelectric buffer with the first ampholytic sample component, and obtaining the first ampholytic sample component in a non-isoelectric state on one side of an isoelectric separation barrier at the end of an isoelectric trapping process.

  一种通过等电俘获改变含两性溶解成分样品初始组成的方法规定，选择 pI 值不同于样品中第一两性溶解样品成分 pI 值的第一等电缓冲液，将等电缓冲液与第一两性溶解样品成分接触，在等电俘获过程结束时，在等电分离屏障的一侧获得非等电状态的第一两性溶解样品成分。
• Method for ph-biased isoelectric trapping separations
  申请人：Vigh Gyula

  公开号：US20060151325A1

  公开（公告）日：2006-07-13

  A method for separating an ampholytic component by electrophoresis, the method involving placing a sample containing an ampholytic component having a pI value in an electrophoresis separation system comprising an anolyte having a pH and a catholyte having a pH, the catholyte pH being higher than the anolyte pH, one or more ion-permeable barriers disposed between the anolyte and catholyte wherein at least one of the barriers is an isoelectric barrier having a pI value which is higher than the anolyte pH and lower than the catholyte pH; providing an isoelectric buffer having a pI value higher than the pH of the anolyte and lower than the pH of the catholyte and different from the pI value of the ampholytic sample component and different from the pI value of an ion-permeable isoelectric barrier; and exposing the sample to an electric potential so as to trap the ampholytic sample component in a non-isoelectric state in the presence of the isoelectric buffer in the electrophoresis system.

  一种通过电泳分离两性溶解成分的方法，该方法涉及将含有具有 pI 值的两性溶解成分的样品置于电泳分离系统中，该系统包括具有 pH 值的溶解液和具有 pH 值的阴溶液，阴溶液的 pH 值高于溶解液的 pH 值；设置在溶解液和阴溶液之间的一个或多个离子渗透屏障，其中至少一个屏障是等电屏障，其 pI 值高于溶解液的 pH 值且低于阴溶液的 pH 值；提供一种等电缓冲液，其 pI 值高于阳离子溶解液的 pH 值，低于阴离子溶解液的 pH 值，不同于两性样品组分的 pI 值，也不同于离子渗透性等电屏障的 pI 值；以及 将样品暴露于电势下，以便在电泳系统中存在等电缓冲液的情况下将两性样品组分俘获在非等电状态下。
• FLUOROCARBON EMULSIONS CONTAINING AMINO ACID BASED ANTI-INFLAMMATORY AGENTS AND BUFFER SYSTEMS
  申请人：ALLIANCE PHARMACEUTICAL, INC.

  公开号：EP0494974A1

  公开（公告）日：1992-07-22
• EP0494974A4
  申请人：——

  公开号：EP0494974A4

  公开（公告）日：1992-09-02