(S)-7-Methyl-2,3,4,6,7,8-hexahydro-1H-quinolin-5-one | 1008-34-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (S)-7-Methyl-2,3,4,6,7,8-hexahydro-1H-quinolin-5-one
• 英文别名: (7S)-7-methyl-2,3,4,6,7,8-hexahydro-1H-quinolin-5-one
• CAS: 1008-34-0
• 化学式: C₁₀H₁₅NO
• 分子量: 165.235
• InChiKey: YUHMIJGDEHBKLZ-ZETCQYMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (S)-7-Methyl-2,3,4,6,7,8-hexahydro-1H-quinolin-5-one 在 manganese triacetate 作用下， 以 苯 为溶剂， 反应 0.33h， 以65%的产率得到(7S)-7-methyl-7,8-dihydro-6H-quinolin-5-one
  参考文献：
  名称：

  Mn(OAc)3-Based α’-Oxidative Acetoxylation of N-Trifluoroacetyl Vinylogous Amides

  摘要：

  Vinylogous amides 1 and 11 are oxidized by dried Mn(OAc)(3) in benzene at 90 degrees C to pyridines 5 and 12, respectively, whereas the analogous N-trifluoroacetyl vinylogous amides 6 and 13 are oxidized by dried Mn(OAc)(3) in benzene at 120 degrees C to give acetates 7 and 14. The alpha'-oxo radicals that are generated in this oxidation cyclize to proximal double bonds to give tricylic alkenes such as 20.

  DOI：

  10.3987/com-12-s(n)95

文献信息

• Mn(OAc)3-Based α’-Oxidative Acetoxylation of N-Trifluoroacetyl Vinylogous Amides
  作者：Barry B. Snider、Hong-Yu Lin

  DOI：10.3987/com-12-s(n)95

  日期：——

  Vinylogous amides 1 and 11 are oxidized by dried Mn(OAc)(3) in benzene at 90 degrees C to pyridines 5 and 12, respectively, whereas the analogous N-trifluoroacetyl vinylogous amides 6 and 13 are oxidized by dried Mn(OAc)(3) in benzene at 120 degrees C to give acetates 7 and 14. The alpha'-oxo radicals that are generated in this oxidation cyclize to proximal double bonds to give tricylic alkenes such as 20.