1,3,4,6-tetra-O-acetyl-2-deoxy-2-(propanoylamino)hexopyranose

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,3,4,6-tetra-O-acetyl-2-deoxy-2-(propanoylamino)hexopyranose
• 英文别名: [3,4,6-triacetyloxy-5-(propanoylamino)oxan-2-yl]methyl acetate
• 化学式: C₁₇H₂₅NO₁₀
• mdl: MFCD01364980
• 分子量: 403.4
• InChiKey: CREWSAARWKDFND-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  28
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  144
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• BIVALENT TARGETED CONJUGATES
  申请人：Arbutus Biopharma Corporation

  公开号：EP3873486A1

  公开（公告）日：2021-09-08
• IN-VIVO RELEASE SUSTAINED RECOMBINANT COAGULATION FACTOR VIII AND PREPARATION METHOD THEREFOR
  申请人：MOGAM INSTITUTE FOR BIOMEDICAL RESEARCH

  公开号：US20210079062A1

  公开（公告）日：2021-03-18

  An in-vivo release-sustained recombinant coagulation factor VIII and a method for making it are disclosed. The recombinant coagulation factor VIII has a biocompatible polymer that is conjugated to at least one sugar chain terminus. The in-vivo release-sustained recombinant coagulation factor VIII has a protein surface modified through a method more elaborate and safer than conventional glycoconjugation techniques and enjoys the advantage of decreasing in immunogenicity and increasing in in-vivo sustainability.