2-[(4-Chlorophenyl)sulfanyl]-4-(4-ethoxyphenyl)-4-oxobutanoic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-[(4-Chlorophenyl)sulfanyl]-4-(4-ethoxyphenyl)-4-oxobutanoic acid
• 英文别名: 2-(4-chlorophenyl)sulfanyl-4-(4-ethoxyphenyl)-4-oxobutanoic acid
• 化学式: C₁₈H₁₇ClO₄S
• 分子量: 364.8
• InChiKey: ZROHCIIRJKRMCU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  88.9
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Modulation of dynein in skin
  申请人：Avon Products, Inc.

  公开号：EP2889384A1

  公开（公告）日：2015-07-01

  Methods for preventing, ameliorating, or reducing dermatological signs of aging are provided which employ active agents that modulate dynein expression in the skin. Also provided are methods for screening for substances which modulate dynein expression levels and the methods of using active agents identified by the screening protocol in the treatment of skin.

  本研究提供了预防、改善或减少皮肤老化迹象的方法，这些方法采用了可调节皮肤中染料蛋白表达的活性剂。此外，还提供了筛选可调节染料蛋白表达水平的物质的方法，以及使用筛选方案确定的活性剂治疗皮肤的方法。
• TOPICAL LIGHTENING COMPOSITION AND USES THEREOF
  申请人：Avon Products, Inc.

  公开号：EP2521558A1

  公开（公告）日：2012-11-14
• MODULATION OF DYNEIN IN SKIN
  申请人：Avon Products, Inc.

  公开号：EP2659004B1

  公开（公告）日：2017-08-30
• Method for identifying active agents for improving the aesthetic appearance of human skin
  申请人：Avon Products, Inc.

  公开号：EP2889384B1

  公开（公告）日：2016-09-28
• Topical Lightening Composition and Uses Thereof
  申请人：Lyga John W.

  公开号：US20120003168A1

  公开（公告）日：2012-01-05

  The disclosure relates to novel topical lightening compositions a skin depigmenting agent and a vehicle. There is provided a topical lightening composition comprising a substituted-4-oxobutanoic acid, ester, or amide tyrosinase inhibitor, and a vehicle. The depigmenting agents of this disclosure can be used as such or as a pharmaceutically acceptable salt including conventional non-toxic salts which include a metal salt or an alkaline earth metal salt, an ammonium salt, or an organic base salt. The depigmenting agents of this disclosure can be incorporated into any cosmetically-, dermatologically-, or cosmeticatically-acceptable vehicle or carrier normally used for topical application. The compositions and methods of the disclosure are effective to lighten skin, hair, lips, and/or nails.