5-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-1,2,4-triazole-3-carboxamide | 62404-64-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-1,2,4-triazole-3-carboxamide
• CAS: 62404-64-2
• 化学式: C₈H₁₂N₄O₅
• 分子量: 244.2
• InChiKey: UZAZHIXEGDBPKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  155
• 氢给体数：
  5
• 氢受体数：
  7

文献信息

• [EN] SMALL MOLECULE INHIBITORS OF VIRAL REPLICATION<br/>[FR] INHIBITEURS À PETITES MOLÉCULES DE RÉPLICATION VIRALE
  申请人：UNIV PRINCETON

  公开号：WO2020231979A1

  公开（公告）日：2020-11-19

  Provided herein are methods involving a compound of the following structural formula: (I) or a pharmaceutically acceptable salt thereof, wherein values for the variables are as described herein. For example, methods for inhibiting replication of a virus, treating a viral infection, inhibiting heat shock protein 90 and treating a heat shock protein 90-mediated disease or condition using a compound of Structural Formula I are provided.