5-Acetyl-1-[2-(3-chloro-5-trifluoromethyl-pyridin-2-ylamino)-ethyl]-1H-pyrimidine-2,4-dione | 338399-27-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-Acetyl-1-[2-(3-chloro-5-trifluoromethyl-pyridin-2-ylamino)-ethyl]-1H-pyrimidine-2,4-dione
• 英文别名: 5-acetyl-1-(2-{[3-chloro-5-(trifluoromethyl)-2-pyridinyl]amino}ethyl)-2,4(1H,3H)-pyrimidinedione；5-acetyl-1-[2-[[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino]ethyl]pyrimidine-2,4-dione
• CAS: 338399-27-2
• 化学式: C₁₄H₁₂ClF₃N₄O₃
• 分子量: 376.722
• InChiKey: ZAHRPODITDJNQC-UHFFFAOYSA-N

物化性质

• 密度：
  1.511±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  91.4
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Methods for treatment of cancer or neoplastic disease and for inhibiting growth of cancer cells and neoplastic cells
  申请人：Gemin X Biotechnologies Inc.

  公开号：US20030119894A1

  公开（公告）日：2003-06-26

  The present invention provides methods for treating or preventing cancer or neoplastic disease comprising administering to a patient a compound having the features of a pharmacophore for human anti-apotptotic Bcl protein inhibitors or identified by the in vitro methods for identifying anti-apotptotic-Bcl protein inhibitors. Also disclosed are methods for inhibiting the growth of a cancer cell or a neoplastic cell, comprising contacting the cancer cell or neoplastic cell with a compound having the features of a pharmacophore for human anti-apoptotic-Bcl protein inhibitors.

  本发明提供了治疗或预防癌症或肿瘤性疾病的方法，包括向患者施用具有人类抗凋亡Bcl蛋白抑制剂药效团特征或通过体外识别抗凋亡Bcl蛋白抑制剂的方法鉴定的化合物。本发明还揭示了抑制癌细胞或肿瘤细胞生长的方法，包括将具有人类抗凋亡Bcl蛋白抑制剂药效团特征的化合物与癌细胞或肿瘤细胞接触。
• Compositions and methods for altering immune function
  申请人：Howard Laurence

  公开号：US20070041981A1

  公开（公告）日：2007-02-22

  The present invention relates to molecules that stabilize and/or enhance CD154 activity, compositions comprising these molecules, methods for using these molecules and compositions (e.g., pharmaceutical compositions) comprising them. Specifically, the molecules can be used for enhancing immune function (e.g., enhancing Th1 cytokine expression), stimulating immune responses, and/or treating certain disorders (e.g., cancer, infectious disease, and immune compromised states). The invention also relates to kits and compositions comprising the molecules.
• US7601355B2
  申请人：——

  公开号：US7601355B2

  公开（公告）日：2009-10-13
• [EN] METHODS FOR TREATMENT OF PREVENTION OF CANCER OR NEOPLASTIC DISEASES<br/>[FR] METHODES DE TRAITEMENT OU DE PREVENTION DU CANCER OU DE MALADIES NEOPLASIQUES
  申请人：GEMIN X BIOTECHNOLOGIES INC

  公开号：WO2003015788A1

  公开（公告）日：2003-02-27

  The present invention provides methods for treating or preventing cancer or neoplastic disease comprising administering to a patient a compound having the features of a pharmacophore for human anti-apotptotic Bcl protein inhibitors or identified by the in vitro methods for identifying anti-apotptotic-Bcl protein inhibitors. Also disclosed are methods for inhibiting the growth of a cancer cell or a neoplastic cell, comprising contacting the cancer cell or neoplastic cell with a compound having the features of a pharmacophore for human anti-apoptotic-Bcl protein inhibitors.
• [EN] COMPOSITIONS AND METHODS FOR ALTERING IMMUNE FUNCTION<br/>[FR] COMPOSITIONS ET MÉTHODES POUR ALTÉRER UNE FONCTION IMMUNITAIRE
  申请人：UNIV NORTHWESTERN

  公开号：WO2007053189A2

  公开（公告）日：2007-05-10

  [EN] The present invention relates to molecules that stabilize and/or enhance CD 154 activity, compositions comprising these molecules, methods for using these molecules and compositions (e.g., pharmaceutical compositions) comprising them. Specifically, the molecules can be used for enhancing immune function (e.g., enhancing ThI cytokine expression), stimulating immune responses, and/or treating certain disorders (e.g., cancer, infectious disease, and immune compromised states). The invention also relates to kits and compositions comprising the molecules.
  [FR] La présente invention concerne des molécules qui stabilisent et/ou accentuent l'activité de CD 154, des compositions qui comprennent lesdites molécules, des méthodes pour utiliser lesdites molécules et des compositions (par exemple, des compositions pharmaceutiques) qui les contiennent. Spécifiquement, lesdites molécules peuvent être utilisées pour accentuer une fonction immunitaire (par exemple, accentuer l'expression de la cytokine ThI), pour stimuler des réponses immunitaires et/ou traiter certains troubles (par exemple, cancers, maladies infectieuses et états immunitaires compromis). L'invention concerne aussi des nécessaires et des compositions qui contiennent lesdites molécules.