1-phenyl-5-[(1S)-1-phenylethyl]sulfanyltetrazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-phenyl-5-[(1S)-1-phenylethyl]sulfanyltetrazole
• 化学式: C₁₅H₁₄N₄S
• 分子量: 282.369
• InChiKey: LVCJOCFROVOEKZ-LBPRGKRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.52
• 重原子数：
  20.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  43.6
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  (S)-(-)-1-苯乙醇 、 1-苯基-5-巯基四氮唑 在 gallium(III) triflate 作用下， 以 二氯甲烷 为溶剂， 生成 1-phenyl-5-[(1R)-1-phenylethyl]sulfanyltetrazole 、 1-phenyl-5-[(1S)-1-phenylethyl]sulfanyltetrazole
  参考文献：
  名称：

  Ga(OTf)₃-Catalyzed Direct Substitution of Alcohols with Sulfur Nucleophiles

  摘要：

  It is reported that Ga(OTf)(3) catalyzes the direct displacement of alcohols with sulfur nucleophiles. The products are versatile intermediates that can be utilized in carbon carbon, carbon sulfur bond formation or used in modified Julia olefination reactions. The only byproduct generated is water.

  DOI：

  10.1021/ol102565b

文献信息

• Ga(OTf)₃-Catalyzed Direct Substitution of Alcohols with Sulfur Nucleophiles
  作者：Xinping Han、Jimmy Wu

  DOI：10.1021/ol102565b

  日期：2010.12.17

  It is reported that Ga(OTf)(3) catalyzes the direct displacement of alcohols with sulfur nucleophiles. The products are versatile intermediates that can be utilized in carbon carbon, carbon sulfur bond formation or used in modified Julia olefination reactions. The only byproduct generated is water.