2,6-bis[phenylmethylidene]cyclohexanone | 251909-29-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 2,6-bis[phenylmethylidene]cyclohexanone
• 英文别名: 2,6-bis(phenylmethylene)cyclohexanone；2,6-dibenzalcyclohexanone；2,6-Bis(benzylidene)cyclohexanone；(2E,6Z)-2,6-dibenzylidenecyclohexan-1-one
• CAS: 251909-29-2
• 化学式: C₂₀H₁₈O
• mdl: MFCD00156772
• 分子量: 274.362
• InChiKey: CTKKGXDAWIAYSA-KPNKYRRCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,6-bis[phenylmethylidene]cyclohexanone 、 3-(dimethylamino)propylhydrazine 以 甲醇 、 水 为溶剂， 生成 3,3a,4,5,6,7-Hexahydro-N,N-dimethyl-3-phenyl-7-(phenylmethylen)-2H-indazol-2-propanamin-oxalat
  参考文献：
  名称：

  2-Aminoalky

  摘要：

  以下公式化合物及其酸加成物、季铵盐和N-氧化物 ##SPC1## 其中X是氢、氯、氟、三氟甲基、低碳烷基或低碳氧基，R是氢或低碳烷基，A是1至8碳原子的烷基，B是--NH.sub.2, ##EQU1## 其中R.sup.1是低碳烷基，R.sup.2是苯或苯基-低碳烷基。这些化合物可用作中枢神经系统抑制剂。

  公开号：

  US03957762A1
• 作为产物：
  描述：

  2,6-bis(benzylidene)cyclohexanone 以 氘代二甲亚砜 为溶剂， 反应 730.5h， 生成 2,6-bis[phenylmethylidene]cyclohexanone 、 2,6-bis[phenylmethylidene]cyclohexanone
  参考文献：
  名称：

  The synthesis of highly functionalised pyridines using Ghosez-type reactions of dihydropyrazoles

  摘要：

  The aza-Diels-Alder reaction of alpha beta-unsaturated hydrazones is a general methodology that has been applied both to the synthesis of natural products and to the development of multicomponent reactions. Trends have emerged as to the effect of substituents on the efficiency of this reaction with substituents at the C2 and C4-positions of the aza-diene in general suppressing the reaction. Here we report that 4,5-dihydropyrazoles can function as substrates in this process despite the presence of substituents at both of these positions. A one pot, four chemical step sequence carried out under standard thermal or microwave conditions results in the formation of the corresponding pyridine-containing compounds. The scope of the reaction is explored and additional insights into the proposed mechanism of this reaction are provided. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.07.063

文献信息

• Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states
  申请人：——

  公开号：US20020040029A1

  公开（公告）日：2002-04-04

  The present invention relates to chalcone and chalcone derivatives and analogs which are useful as angiogenesis inhibitors. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good activity as angiogenesis inhibitors. The present invention also relates to the use of chalcone and its analogs as antitumor/anticancer agents and to treat a number of conditions or disease states in which angiogenesis is a factor, including angiongenic skin diseases such as psoriasis, acne, rosacea, warts, eczema, hemangiomas, lymphangiogenesis, among numerous others, as well as chronic inflammatory disease such as arthritis.

  本发明涉及香豆素和香豆素衍生物以及类似物，这些化合物可用作抗血管生成抑制剂。这些化合物的合成成本低廉，并表现出出乎意料的良好的抗血管生成活性。本发明还涉及使用香豆素及其类似物作为抗肿瘤/抗癌剂，以及治疗一些与血管生成有关的疾病或病态，包括血管生成性皮肤病如牛皮癣、痤疮、酒渣鼻、疣、湿疹、血管瘤、淋巴管生成等等，以及慢性炎症性疾病如关节炎。
• Antibacterial Agent, Substrate Surface Treatment Method Using The Same, Antibacterial Agent Composition, And Substrate Surface Treatment Method Using The Same
  申请人：Komoriya Haruhiko

  公开号：US20130189220A1

  公开（公告）日：2013-07-25

  [Problem] To provide an antibacterial agent which can be limited to the required location on the surface of a material without mixing and has excellent antibacterial, antifungal and antiviral effects even at low concentrations of the active component without elution or volatilization. [Solution] An antibacterial agent that contains as an active component a resin having an organic group represented by general formula (I-1). (In the formula (I-1), R 1 and R 2 mutually independently represent a C 1 -C 4 fluoroalkyl group. “C” and “A” are bonded to each other through a covalent bond or an ionic bond, and “A” represents a hydrogen atom or a cation.)

  [问题] 提供一种抗菌剂，可以将其限制在材料表面的所需位置，而不混合，并且即使在活性成分低浓度下也具有出色的抗菌，抗真菌和抗病毒效果，而不会出现溶出或挥发。 [解决方案] 一种抗菌剂，其包含有机基团为通式（I-1）所表示的树脂作为活性成分。（在通式（I-1）中，R1和R2互相独立地表示C1-C4氟代烷基。 “C”和“A”通过共价键或离子键彼此连接，“A”表示氢原子或阳离子。）
• Cancer treatment using curcumin derivatives
  申请人：Vander Jagt L. David

  公开号：US20060276536A1

  公开（公告）日：2006-12-07

  Cancer or a precancerous condition is treated by administering a curcumin derivative to a subject.

  癌症或癌前病变可以通过向受试者施用姜黄素衍生物来治疗。
• Therapeutic curcumin derivatives
  申请人：Vander Jagt L. David

  公开号：US20070060644A1

  公开（公告）日：2007-03-15

  Curcumin analogues and methods are provided for treatment of disease.

  提供了类姜黄素和治疗疾病的方法。
• THERAPEUTIC CURCUMIN DERIVATIVES
  申请人：STC.UNM

  公开号：US20150011494A1

  公开（公告）日：2015-01-08

  Curcumin analogues and methods are provided for treatment of disease.

  提供了类姜黄素及其方法，用于治疗疾病。