dichloropalladium;dicyclohexyl-[2-(2,6-dimethoxyphenyl)phenyl]phosphane

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: dichloropalladium;dicyclohexyl-[2-(2,6-dimethoxyphenyl)phenyl]phosphane
• 化学式: C₂₆H₃₂N₃O₅Pol
• InChiKey: DNMZGCHLJMAADK-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  15.66
• 重原子数：
  61
• 可旋转键数：
  12
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  dichloropalladium;dicyclohexyl-[2-(2,6-dimethoxyphenyl)phenyl]phosphane 、 丹酰氯 在 哌啶 、 三乙胺 、 三异丙基硅烷 、 三氟乙酸 作用下， 以 N,N-二甲基甲酰胺 、 水 为溶剂， 反应 3.0h， 生成
  参考文献：
  名称：

  Two dansyl fluorophores bearing amino acid for monitoring Hg2+ in aqueous solution and live cells

  摘要：

  A series of compounds (1-4) bearing one or two dansyl fluorophore(s) based on a Lys amino acid were synthesized in solid phase synthesis. Among them, two dansyl labeled Lys amino acid 3 detected Hg2+ in a 100% aqueous solution with high sensitivity (K-d=4.3 nM) via a turn-on response. Compound 3 was applied for monitoring Hg2+ in environmental and biological fields. 3 showed a hypersensitive response to Hg2+ without interferences from other metal ions and satisfied the requirements for monitoring the maximum allowable level (2 ppb) of mercury ions in drinking water demanded by EPA. In addition, 3 penetrated living HeLa cells and detected intracellular Hg2+. The organic spectroscopic data revealed the two sulfonamide and amide groups of 3 played a key role in stabilizing the 3-Hg2+ complex. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.03.106
• 作为产物：
  描述：

  NAlpha-BOC-Nε-FMOC-L-赖氨酸 在 1-羟基苯并三唑 、 N,N'-二异丙基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 dichloropalladium;dicyclohexyl-[2-(2,6-dimethoxyphenyl)phenyl]phosphane
  参考文献：
  名称：

  Two dansyl fluorophores bearing amino acid for monitoring Hg2+ in aqueous solution and live cells

  摘要：

  A series of compounds (1-4) bearing one or two dansyl fluorophore(s) based on a Lys amino acid were synthesized in solid phase synthesis. Among them, two dansyl labeled Lys amino acid 3 detected Hg2+ in a 100% aqueous solution with high sensitivity (K-d=4.3 nM) via a turn-on response. Compound 3 was applied for monitoring Hg2+ in environmental and biological fields. 3 showed a hypersensitive response to Hg2+ without interferences from other metal ions and satisfied the requirements for monitoring the maximum allowable level (2 ppb) of mercury ions in drinking water demanded by EPA. In addition, 3 penetrated living HeLa cells and detected intracellular Hg2+. The organic spectroscopic data revealed the two sulfonamide and amide groups of 3 played a key role in stabilizing the 3-Hg2+ complex. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.03.106
• 作为试剂：
  描述：

  (S,R(p))-1-iodo-[(4-methylphenyl)sulfinyl]-ferrocene 、 苯硼酸 在 dichloropalladium;dicyclohexyl-[2-(2,6-dimethoxyphenyl)phenyl]phosphane 、 caesium carbonate 作用下， 以 四氢呋喃 、 水 、 甲苯 为溶剂， 反应 16.0h， 以70%的产率得到(S,S)-2-phenyl-1-p-tolylsulfinylferrocene
  参考文献：
  名称：

  平面手性二茂铁基膦-金 (I) 配合物在 3-羟基化 1,5-烯炔的不对称环异构化中的应用

  摘要：

  已经制备了基于邻位二取代二茂铁单元的手性单齿膦并用于合成金 (I) 配合物。这些配合物是将 3-羟基-1,5-烯炔环异构化为双环[3.1.0]己酮的高活性催化剂。它们的高催化活性归因于它们与基于联芳基的 Buchwald 膦的结构相似。该论文公开了基于金催化的这些反应的第一个对映选择性变体（ee 高达 80%）。

  DOI：

  10.1002/ejoc.201501121

文献信息

• Catalysts for Suzuki−Miyaura Coupling Processes:  Scope and Studies of the Effect of Ligand Structure
  作者：Timothy E. Barder、Shawn D. Walker、Joseph R. Martinelli、Stephen L. Buchwald

  DOI：10.1021/ja042491j

  日期：2005.4.1

  catalyst levels, to prepare extremely hindered biaryls and to be carried out, in general, for reactions of aryl chlorides at room temperature. Additionally, structural studies of various 1.Pd complexes are presented along with computational data that help elucidate the efficacy that 1 imparts on Suzuki-Miyaura coupling processes. Moreover, a comparison of the reactions with 1 and with 2-(2',4',6'-t

  芳基和杂芳基卤化物与芳基-、杂芳基-和乙烯基硼酸的 Suzuki-Miyaura 偶联反应使用 2-(2',6'-二甲氧基联苯) 二环己基膦 SPhos (1) 以非常好的收率进行。这种配体为这些过程提供了前所未有的活性，允许在低催化剂水平下进行反应，制备极受阻的联芳基化合物，并且通常在室温下进行芳基氯的反应。此外，还介绍了各种 1.Pd 配合物的结构研究以及有助于阐明 1 对 Suzuki-Miyaura 偶联过程的功效的计算数据。此外，与 1 和 2-(2',4',6' -三异丙基联苯）二苯基膦（2）在确定配体体积和给电子能力在源自此类配体的催化剂的高活性中的相对重要性方面提供了信息。此外，当芳基溴变得太受阻时，一个有趣的 CH 键官能化-交叉偶联序列会介入以提供高产率的产物。
• Evidences for complex formation between l-dabPNA and aegPNA
  作者：Giovanni N. Roviello、Domenica Musumeci、Enrico M. Bucci、Mariangela Castiglione、Annalisa Cesarani、Carlo Pedone、Gennaro Piccialli

  DOI：10.1016/j.bmcl.2008.08.005

  日期：2008.9

  based on a l-diaminobutyric acid (l-DABA) backbone (dabPNA), and its binding studies with a complementary aegPNA. We demonstrated by CD and UV experiments that the l-dabPNA binds the aegPNA forming a complex with good thermal stability, that we identified as a left-handed triplex.

  继续我们作为生物医学和生物工程应用的ODN类似物开发核苷酸的研究，在此我们报告基于l-二氨基丁酸（l-DABA）主链（dabPNA）的高腺嘌呤六聚体的合成和化学物理表征，以及其与互补aegPNA的结合研究。我们通过CD和UV实验证明，l-dabPNA与aegPNA结合形成了具有良好热稳定性的复合物，我们将其鉴定为左手三元组。
• Identification of a Hit Series of Antileishmanial Compounds through the Use of Mixture-Based Libraries
  作者：Marc A. Giulianotti、Brian A. Vesely、Ala Azhari、Ashley Souza、Travis LaVoi、Richard A. Houghten、Dennis E. Kyle、James W. Leahy

  DOI：10.1021/acsmedchemlett.7b00045

  日期：2017.8.10

  From a screening campaign that included mixture-based libraries containing more than 6 million compounds, a lead series of bis-cyclic guanidines was identified as the most promising. Lead optimization resulted in the identification of potent (IC50 < 500 nM) and selective compounds within this series as well as potent and selective monoguanidines.
• Synthesis, Structural, and Electron Topographical Analyses of a Dialkylbiaryl Phosphine/Arene-Ligated Palladium(I) Dimer:  Enhanced Reactivity in Suzuki−Miyaura Coupling Reactions
  作者：Timothy E. Barder

  DOI：10.1021/ja0558995

  日期：2006.1.1

  The treatment of bis(2-(dicyclohexylphosphino)-2',6'-dimethoxybiphenyl)PdCl2 with AgBF4 produces an air-stable phosphine/arene-ligated Pd(I) dimer with two seemingly identical Pd-arene interactions by X-ray crystallography. However, NMR and theoretical electron topographical analyses of this complex distinguish between these two interactions. One interaction is classified as an arenium-like complex, while the other is classified as a,pi-interaction. Additionally, this complex is a suitable precatalyst for high yielding Suzuki-Miyaura coupling reactions in short reaction times.
• Two dansyl fluorophores bearing amino acid for monitoring Hg2+ in aqueous solution and live cells
  作者：Chuda Raj Lohani、Joung Min Kim、Keun-Hyeung Lee

  DOI：10.1016/j.tet.2011.03.106

  日期：2011.6

  A series of compounds (1-4) bearing one or two dansyl fluorophore(s) based on a Lys amino acid were synthesized in solid phase synthesis. Among them, two dansyl labeled Lys amino acid 3 detected Hg2+ in a 100% aqueous solution with high sensitivity (K-d=4.3 nM) via a turn-on response. Compound 3 was applied for monitoring Hg2+ in environmental and biological fields. 3 showed a hypersensitive response to Hg2+ without interferences from other metal ions and satisfied the requirements for monitoring the maximum allowable level (2 ppb) of mercury ions in drinking water demanded by EPA. In addition, 3 penetrated living HeLa cells and detected intracellular Hg2+. The organic spectroscopic data revealed the two sulfonamide and amide groups of 3 played a key role in stabilizing the 3-Hg2+ complex. (C) 2011 Elsevier Ltd. All rights reserved.