N,N'-二环己基丙二酰胺 | 10256-00-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: N,N'-二环己基丙二酰胺
• 英文名称: Malonsaeure-N,N'-dicyclohexyldiamid
• 英文别名: N,N'-Dicyclohexyl-malonsaeure-diamid；Propanediamide, N,N'-dicyclohexyl-；N,N'-dicyclohexylpropanediamide
• CAS: 10256-00-5
• 化学式: C₁₅H₂₆N₂O₂
• mdl: MFCD00431335
• 分子量: 266.384
• InChiKey: LLWDZKXTXQFQKQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.866
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2924299090

反应信息

• 作为反应物：
  描述：

  N,N'-二环己基丙二酰胺 在 tetraphosphorus decasulfide 作用下， 以 xylene 为溶剂， 生成 N,N'-di-cyclohexyldithiomalonamide
  参考文献：
  名称：

  Kisenyi, Jonathan M.; Willey, Gerald R.; Drew, Michael G. B., Journal of the Chemical Society, Dalton Transactions, 1985, p. 1073 - 1076

  摘要：

  DOI：
• 作为产物：
  描述：

  Ethyl Acetyl-N-cyclohexylmalonamate 以 乙醇 为溶剂， 反应 5.5h， 生成 N,N'-二环己基丙二酰胺
  参考文献：
  名称：

  Reactions of acetoacetic ester blocked cyclohexyl isocyanate

  摘要：

  DOI：

  10.1021/jo01300a036

文献信息

• 3-Formylchromones in Guareschi Synthesis of 5-(2-hydroxybenzoyl)-2-pyridones
  作者：Dmitriy M. Volochnyuk、Sergey V. Ryabukhin、Andrey S. Plaskon、Andrey A. Tolmachev

  DOI：10.1055/s-2004-832852

  日期：——

  A set of 5-(2-hydroxybenzoyl)-pyrid-2-ones, which are analogous to cardiotonic drugs such as milrinone, has been prepared in high yield by recyclization of 3-formylchromones with acetic acid amides having at the α-position an electron-withdrawing group. The best reaction conditions were found to be heating in DMF in the presence of Me3SiCl as a promoter and water scavenger.

  一组5-(2-羟基苯甲酰)-吡啶-2-酮的化合物，类似于米利酮等强心药，通过将3-醛基香豆素与在α位具有电子吸引基团的乙酸酰胺进行再环化高产量制备而成。最佳反应条件是将反应体系加热于DMF中，并添加Me3SiCl作为促进剂和脱水剂。
• A Pyridinium Derivatization Reagent for Highly Sensitive Detection of Poly(carboxylic acid)s Using Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry
  作者：Shimba Kawasue、Yohei Sakaguchi、Reiko Koga、Hideyuki Yoshida、Hitoshi Nohta

  DOI：10.1021/jasms.2c00086

  日期：2022.8.3

  polarity of their carboxyl groups. Various derivatization methods have been developed; however, most are effective only for monocarboxylic acids and not for those having multiple carboxyl groups. Therefore, we successfully attempted to synthesize a derivatization reagent that could analyze both mono- and poly(carboxylic acid)s with high sensitivity. We optimized our derivatization reagent by modifying the

  由于其羧基的高极性，短链脂肪酸难以使用液相色谱-电喷雾电离-质谱 (LC-ESI-MS) 进行高灵敏度分析。已经开发了各种衍生化方法；然而，大多数仅对一元羧酸有效，而对具有多个羧基的那些无效。因此，我们成功地尝试合成一种衍生化试剂，该试剂可以以高灵敏度分析单和聚（羧酸）。我们通过修改反应位点的结构、衍生化合物的疏水性以及将反应位点连接到永久带电子结构的接头结构来优化我们的衍生化试剂。通过使用哌啶部分作为反应位点，提高了对羧基的反应性，高疏水性和永久带电的三苯基吡啶鎓基团提高了 ESI 效率。此外，烷基接头的加入使多标记成为可能。当优化的试剂应用于单、二、三和四羧酸时，ESI 效率随着多标记而增加；因此，我们的衍生化试剂优于现有的衍生化方法，并且能够以高灵敏度分析聚（羧酸）。由于该衍生试剂可应用于大多数含羧基化合物，因此可广泛用于脂质组学、蛋白质组学和代谢组学。三羧酸和四羧酸，ESI 效率随
• Non-toxic corrosion-protection pigments based on manganese
  申请人：——

  公开号：US20040011252A1

  公开（公告）日：2004-01-22

  Corrosion-inhibiting pigments based on manganese are described that contain a trivalent or tetravalent manganese/valence stabilizer complex. An inorganic or organic material is used to stabilize the trivalent or tetravalent manganese ion to form a compound that is sparingly soluble, exhibits low solubility, or is insoluble in water, depending upon the intended usage. Specific stabilizers are chosen to control the release rate of trivalent or tetravalent manganese during exposure to water and to tailor the compatibility of the powder when used as a pigment in a chosen binder system. Stabilizers may also modify the processing and handling characteristics of the formed powders. Manganese/valence stabilizer combinations are chosen based on the well-founded principles of manganese coordination chemistry. Many manganese-valence stabilizer combinations are presented that can equal the performance of conventional hexavalent chromium or tetravalent lead systems. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.

  以锰为基础的缓蚀颜料含有三价或四价锰/价稳定剂复合物。一种无机或有机材料可用于稳定三价或四价锰离子，从而形成一种可少量溶解、溶解度低或不溶于水的化合物，具体取决于预期用途。选择特定的稳定剂是为了控制三价锰或四价锰在遇水时的释放率，并调整粉末在所选粘合剂体系中用作颜料时的相容性。稳定剂还可以改变成型粉末的加工和处理特性。锰/价稳定剂组合的选择是基于锰配位化学的基本原理。文中介绍了许多锰价稳定剂组合，其性能与传统的六价铬或四价铅体系相当。需要强调的是，提供本摘要是为了符合要求提供摘要的规则，以便检索者或其他读者快速确定技术公开的主题。提交本摘要的前提是，本摘要不用于解释或限制权利要求的范围或含义。
• Non-toxic corrosion-protection pigments based on rare earth elements
  申请人：——

  公开号：US20040104377A1

  公开（公告）日：2004-06-03

  A corrosion-inhibiting pigment comprising a rare earth element and a valence stabilizer combinded to form a rare earth/valence stabilizer complex. The rare earth element is selected from cerium, terbium, praseodymium, or a combination thereof, and at least one rare earth element is in the tetravalent oxidation state. An inorganic or organic material is used to stabilize the tetravalent rare earth ion to form a compound that is sparingly soluble in water. Specific stabilizers are chosen to control the release rate of tetravalent cerium, terbium, or praseodymium during exposure to water and to tailor the compatibility of the powder when used as a pigment in a chosen binder system. Stabilizers may also modify the processing and handling characteristics of the formed powders. Many rare earth-valence stabilizer combinations are presented that can equal the performance of conventional hexavalent chromium systems.

  一种缓蚀颜料，由稀土元素和价态稳定剂结合形成稀土/价态稳定剂复合物。稀土元素选自铈、铽、镨或它们的组合，至少有一种稀土元素处于四价氧化态。使用无机或有机材料来稳定四价稀土离子，以形成稀溶于水的化合物。选择特定的稳定剂是为了控制四价铈、铽或镨在遇水时的释放率，并调整粉末在所选粘合剂体系中用作颜料时的相容性。稳定剂还可以改变成型粉末的加工和处理特性。本文介绍了许多稀土-价稳定剂组合，其性能可与传统的六价铬体系媲美。
• Grunfeld, Annales de Chimie (Cachan, France), 1933, vol. <10> 20, p. 304,367
  作者：Grunfeld

  DOI：——

  日期：——