2,5-Dimethoxytetrahydrofuran-3,4-diol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,5-Dimethoxytetrahydrofuran-3,4-diol
• 英文别名: 2,5-dimethoxyoxolane-3,4-diol
• 化学式: C₆H₁₂O₅
• mdl: MFCD00086215
• 分子量: 164.16
• InChiKey: WNGXQPRWPICLEF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  68.2
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  trans-2,5-Dimethoxy-2,5-dihydro-furan 、 potassium permanganate 、 乙醇 、 水 以70%的产率得到
  参考文献：
  名称：

  HOENEL, M.;MOSHER, H. S., J. ORG. CHEM., 1985, 50, N 22, 4386-4388

  摘要：

  DOI：

文献信息

• Opioid receptor ligands and methods for their preparation
  申请人：Prisinzano Thomas

  公开号：US20060058264A1

  公开（公告）日：2006-03-16

  The invention provides novel compounds of formula I: that are opioid receptor ligands. The invention also provides pharmaceutical compositions comprising such compounds as well as methods for treating diseases associated with opioid receptor function by administering such compounds to a mammal in need of treatment. The invention also provides an improved method for isolating intermediate materials useful for obtaining compounds of formula I.

  该发明提供了公式I的新化合物，这些化合物是阿片受体配体。该发明还提供了包含这些化合物的药物组合物，以及通过向需要治疗的哺乳动物施用这些化合物来治疗与阿片受体功能相关的疾病的方法。该发明还提供了一种改进的方法，用于分离中间体材料，以获得公式I的化合物。
• THERAPEUTIC COMPOUNDS
  申请人：Prisinzano Thomas

  公开号：US20100179217A1

  公开（公告）日：2010-07-15

  The invention provides novel compounds of formula I: that are opioid receptor ligands. The invention also provides pharmaceutical compositions comprising such compounds as well as methods for treating diseases associated with opioid receptor function by administering such compounds to a mammal in need of treatment. Compounds of the invention are useful to modulate (e.g. agonize or antagonize) opioid receptor function.
• CELLULOSE CROSSLINKED FIBERS WITH REDUCED FIBER KNOTS MANUFACTURED FROM PLASMA TREATED PULPSHEETS
  申请人：STOYANOV ANGEL

  公开号：US20120004406A1

  公开（公告）日：2012-01-05

  An intrafiber crosslinked cellulose pulp fiber manufactured from plasma-treated pulp sheet. The crosslinked fiber can have lower sonic knots than an untreated pulp sheet.
• CELLULOSE CROSSLINKED FIBERS MANUFACTURED FROM PLASMA TREATED PULP
  申请人：WEYERHAEUSER NR COMPANY

  公开号：US20130137862A1

  公开（公告）日：2013-05-30

  Intrafiber crosslinked cellulose pulp fibers manufactured from a plasma-treated pulp sheet are provided. The provided fibers have lower knot content and increased wet bulk compared to an untreated pulp sheet. Methods for forming the fibers are also provided.
• US4900324A
  申请人：——

  公开号：US4900324A

  公开（公告）日：1990-02-13