10-tert-butyl-8-formyl-3,4-dihydro-2H,6H-3,6-epoxy-benzo[1,5]dioxocine | 1342894-85-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 10-tert-butyl-8-formyl-3,4-dihydro-2H,6H-3,6-epoxy-benzo[1,5]dioxocine
• 英文别名: 6-Tert-butyl-8,12,13-trioxatricyclo[8.2.1.02,7]trideca-2(7),3,5-triene-4-carbaldehyde；6-tert-butyl-8,12,13-trioxatricyclo[8.2.1.02,7]trideca-2(7),3,5-triene-4-carbaldehyde
• CAS: 1342894-85-2
• 化学式: C₁₅H₁₈O₄
• 分子量: 262.306
• InChiKey: IEQMXEZSHGVWLE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  5-tert-butyl-4-hydroxyisophthalaldehyde 、 环氧氯丙烷 在 三乙胺 作用下， 反应 1.17h， 以92%的产率得到10-tert-butyl-8-formyl-3,4-dihydro-2H,6H-3,6-epoxy-benzo[1,5]dioxocine
  参考文献：
  名称：

  Synthesis of 3,6-epoxy[1,5]dioxocines from 2-hydroxyaromatic benzaldehydes

  摘要：

  Convenient and facile one step synthesis of medicinally relevant new 3,6-epoxy[1,5]dioxocines from 2-hydroxyaromatic benzaldehydes is described. The scope of the method was validated by examining the use of both electron rich and electron-deficient 2-hydroxyaromatic benzaldehydes. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.08.095

文献信息

• Synthesis of 3,6-epoxy[1,5]dioxocines from 2-hydroxyaromatic benzaldehydes
  作者：Koneni V. Sashidhara、Abdhesh Kumar、K. Bhaskara Rao

  DOI：10.1016/j.tetlet.2011.08.095

  日期：2011.10

  Convenient and facile one step synthesis of medicinally relevant new 3,6-epoxy[1,5]dioxocines from 2-hydroxyaromatic benzaldehydes is described. The scope of the method was validated by examining the use of both electron rich and electron-deficient 2-hydroxyaromatic benzaldehydes. (C) 2011 Elsevier Ltd. All rights reserved.