O-Aethyltyramin-Hydrochlorid | 56370-30-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: O-Aethyltyramin-Hydrochlorid
• 英文别名: 2-(4-ethoxyphenyl)ethanamine hydrochloride；4-ethoxy-phenethylamine; hydrochloride；4-Aethoxy-phenaethylamin; Hydrochlorid；2-(4-ethoxyphenyl)ethanamine;hydrochloride
• CAS: 56370-30-0
• 化学式: C₁₀H₁₅NO*ClH
• 分子量: 201.696
• InChiKey: LGGGIJHFLLDSKJ-UHFFFAOYSA-N

物化性质

• 熔点：
  206 °C
• 沸点：
  131°C 20mm
• 密度：
  0,99 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  2.01
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  35.2
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT, CORROSIVE
• 危险品标志：
  Xi,C
• 安全说明：
  S26,S36/37/39
• 危险类别码：
  R34
• 危险品运输编号：
  UN 2734

反应信息

• 作为反应物：
  描述：

  O-Aethyltyramin-Hydrochlorid 、 二聚氰胺 以61%的产率得到
  参考文献：
  名称：

  OVSEPYAN T. R.; GEVORKYAN YU. A.; AROYAN A. A.; STEPANYAN N. S.; BUNYATYA+, AJKAKAN KIMIAKAN AMSAGIR, ARM. XIM. ZH. , 1975, 28, HO 3, 228-23+

  摘要：

  DOI：
• 作为产物：
  描述：

  4-(2-(4-methylbenzylideneamino)ethyl)phenol 、 碘乙烷 在 caesium carbonate 、 盐酸 作用下， 以 甲基叔丁基醚 、 N,N-二甲基甲酰胺 、 水 、 乙酸乙酯 为溶剂， 反应 8.0h， 以91.8%的产率得到O-Aethyltyramin-Hydrochlorid
  参考文献：
  名称：

  Syntheses of a Selective Peroxisome Proliferator Activated Receptor Modulator and Practical New Preparations of 2-(4-Alkoxyphenyl)ethylamines

  摘要：

  This article describes chemistry that was developed to give access to multigram quantities of the selective peroxisome proliferator activated receptor modulator (SPPARM), compound 1.(1) Fischer esterifications, phase transfer-catalyzed alkylations, amide couplings, crystallizations, and a new synthesis were developed to accomplish this task. In addition, an efficient method for preparing 2-(4-alkoxyphenyl)ethylamines 7a-d from tyramine 9 was developed that involves O-alkylation of intermediate Schiff base 11 and subsequent acid-catalyzed hydrolysis to afford the target molecules as crystalline hydrochloride salts.

  DOI：

  10.1021/op800215a

文献信息

• Pharmacologically Active Compounds from Alkoxy-β-phenylethylamines
  作者：Walter S. Ide、Johannes S. Buck

  DOI：10.1021/ja01283a038

  日期：1937.4
• Syntheses of a Selective Peroxisome Proliferator Activated Receptor Modulator and Practical New Preparations of 2-(4-Alkoxyphenyl)ethylamines
  作者：Nicholas A. Magnus、Bret A. Astleford、John Brennan、James R. Stout、Roger W. Tharp-Taylor

  DOI：10.1021/op800215a

  日期：2009.3.20

  This article describes chemistry that was developed to give access to multigram quantities of the selective peroxisome proliferator activated receptor modulator (SPPARM), compound 1.(1) Fischer esterifications, phase transfer-catalyzed alkylations, amide couplings, crystallizations, and a new synthesis were developed to accomplish this task. In addition, an efficient method for preparing 2-(4-alkoxyphenyl)ethylamines 7a-d from tyramine 9 was developed that involves O-alkylation of intermediate Schiff base 11 and subsequent acid-catalyzed hydrolysis to afford the target molecules as crystalline hydrochloride salts.
• OVSEPYAN T. R.; GEVORKYAN YU. A.; AROYAN A. A.; STEPANYAN N. S.; BUNYATYA+, AJKAKAN KIMIAKAN AMSAGIR, ARM. XIM. ZH. <AUKZ-AN>, 1975, 28, HO 3, 228-23+
  作者：OVSEPYAN T. R.、 GEVORKYAN YU. A.、 AROYAN A. A.、 STEPANYAN N. S.、 BUNYATYA+

  DOI：——

  日期：——