2-(2-Hydroxy-propyl)-cyclopent-2-enone | 212517-41-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(2-Hydroxy-propyl)-cyclopent-2-enone
• 英文别名: 2-(2-Hydroxypropyl)-2-cyclopenten-1-one；2-(2-hydroxypropyl)cyclopent-2-en-1-one
• CAS: 212517-41-4
• 化学式: C₈H₁₂O₂
• 分子量: 140.182
• InChiKey: NKIFUVRQRVAEIU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-(trimethylsilyloxy)pent-1-yne 在 [Co₄(CO)11{P(OPh)3}] 盐酸 、 水 作用下， 85.0 ℃ 、21.28 MPa 条件下， 反应 44.0h， 生成 2-(2-Hydroxy-propyl)-cyclopent-2-enone
  参考文献：
  名称：

  Catalytic Intermolecular Pauson - Khand Reactions in Supercritical Ethylene

  摘要：

  Ethylene is not only a substrate, but also a solvent: Catalytic intermolecular Pauson - Khand reactions of terminal alkynes were carried out in supercritical ethylene to provide 2-substituted cyclopentenones in moderate to high yields [Eq. (1)]. Under these conditions, even a low pressure of CO (5 atm) is sufficient for the reaction to take place.

  DOI：

  10.1002/(sici)1521-3773(20000204)39:3<636::aid-anie636>3.0.co;2-s

文献信息

• Catalytic Intermolecular Pauson - Khand Reactions in Supercritical Ethylene
  作者：Nakcheol Jeong、Sung Hee Hwang

  DOI：10.1002/(sici)1521-3773(20000204)39:3<636::aid-anie636>3.0.co;2-s

  日期：2000.2.4

  Ethylene is not only a substrate, but also a solvent: Catalytic intermolecular Pauson - Khand reactions of terminal alkynes were carried out in supercritical ethylene to provide 2-substituted cyclopentenones in moderate to high yields [Eq. (1)]. Under these conditions, even a low pressure of CO (5 atm) is sufficient for the reaction to take place.