(E)-N-(3-methoxy-6-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridine-2-yl)methanesulfonamide | 1353547-89-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (E)-N-(3-methoxy-6-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridine-2-yl)methanesulfonamide
• 英文别名: (E)-N-(3-methoxy-6-((2,4,6-trimethoxystyrylsulfonyl)methyl)pyridin-2-yl)methanesulfonamide；N-[3-methoxy-6-[[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonylmethyl]pyridin-2-yl]methanesulfonamide
• CAS: 1353547-89-3
• 化学式: C₁₉H₂₄N₂O₈S₂
• 分子量: 472.54
• InChiKey: WVNLNSGTKWPSFL-CMDGGOBGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  31
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  147
• 氢给体数：
  1
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  3-羟基-6-甲基-2-硝基吡啶 在 哌啶 、 吡啶 、 N-溴代丁二酰亚胺(NBS) 、 双氧水 、 铁粉 、 potassium carbonate 、 溶剂黄146 、 苯甲酸 、 过氧化苯甲酰 作用下， 以 甲醇 、 水 、 丙酮 、 甲苯 、 乙腈 为溶剂， 反应 80.75h， 生成 (E)-N-(3-methoxy-6-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridine-2-yl)methanesulfonamide
  参考文献：
  名称：

  （E）-3-（（苯乙烯基磺酰基）甲基）吡啶和（E）-2-（（苯乙烯基磺酰基）甲基）吡啶衍生物作为抗癌剂的发现：合成，结构-活性关系和生物活性

  摘要：

  ON01910.Na是一种高效的抗癌剂，可诱导有丝分裂阻滞和细胞凋亡。ON01910在癌症患者中的临床研究显示出疗效以及令人印象深刻的安全性。尽管ON01910对癌细胞具有高活性，但口服利用率低，需要连续静脉输注或多克剂量才能确保患者充分的药物暴露以实现其生物学活性。我们已经确定了两个新颖的苯乙烯基磺酰基-甲基吡啶系列。铅化合物8，图9A，18和19A是高度有效的有丝分裂抑制剂和选择性的细胞毒性，以癌细胞。令人印象深刻的是，这些化合物具有出色的药物特性和两个候选候选药物9a还有18个在动物模型中证明了抗肿瘤活性。

  DOI：

  10.1021/jm4019614

文献信息

• [EN] COMPOUNDS FOR TREATING PROLIFERATIVE DISORDERS<br/>[FR] COMPOSÉS POUR LE TRAITEMENT DE TROUBLES PROLIFÉRATIFS
  申请人：UNIV NOTTINGHAM

  公开号：WO2011161446A1

  公开（公告）日：2011-12-29

  .A compound of formula (I) or a pharmaceutically acceptable salt or solvate or physiologically hydrolysable, solubilising or immobilisable derivative thereof; wherein: any one or two of X·,, X2 and X3 is a N atom and the remaining two or one of X1, X2 and X3 are independently CR13; Y is selected from S02 and SO; R1, R2, R3, and R7 and the one or two R13 groups are each independently selected from H and R10, R10 is selected from R8, alkyl, aryl, heteroaryl and combinations of two or more thereof and combinations with one or more R9, or R10 is one or more moieties R11 Sinking one or more alkyl, alkoxy, aryl, heteroaryl or R8 or R9 groups or combinations thereof, directly or via a moiety selected from alkylene, arylene, heteroarylene or combinations thereof, wherein alkyl, aryl, heteroaryl groups or moieties thereof may be substituted with one or more groups R12, or R10 is selected from a group R12; R11 is selected from 0-, N-, NH-, N=C, CO-, C00-, CON-, CONH-, S02-, S02N-, S02NH-; R12 is selected from halogeno, NH2, N02, CN, OH, COOH, CONH2, C(=NH)NH2, S03H, S02NH2, S02CH3, OCH3, OCH2CH3, CF3; R8 and R9 comprise one or more solubilising moieties independently chosen from i) neutral hydrophilic groups, ii) ionisable organic acids, iii) ionisable organic bases, iv} chemical functions or moieties providing covalent or non-covalent attachment or binding to a solid phase or an immobile receptor and combinations thereof; R4, R5 and R6 are each independently selected from H and R10, or two of R4 to R6 are linked to form a cyclic ether or amine containing one or more additional oxygen or nitrogen atoms. The compound may be used for treating a condition mediated by one or more enzymes selected from AKT, Aurora kinase, BCR-ABL, CDK, FLT, GSK3, IKK, JAK, MAPK, PDGF, PI3K, PKA, PKB, PKC, PLK, Src and VEGF family enzymes, or for treating cancer or other proliferative disorder, or for inhibiting growth of cancer cells, or for inducing apoptosis of cancer cells, in a human or animal subject.

  化合物的化学式（I）或其药学上可接受的盐、溶剂或生理可水解、溶解或固定衍生物；其中：X1、X2和X3中的任意一个或两个是N原子，其余的X1、X2和X3中的一个或两个是独立的CR13；Y从S02和SO中选择；R1、R2、R3和R7以及一个或两个R13基团分别独立选择自H和R10，R10从R8、烷基、芳基、杂环芳基及两种或两种以上的组合以及与一个或多个R9的组合中选择，或R10是一个或多个基团R11，其中沉积一个或多个烷基、烷氧基、芳基、杂环芳基或R8或R9基团或其组合，直接或通过从烷基、芳基、杂环芳基或其组合中选择的基团，其中烷基、芳基、杂环芳基基团或其基团可能被一个或多个基团R12取代，或R10从基团R12中选择；R11从0-、N-、NH-、N=C、CO-、COO-、CON-、CONH-、S02-、S02N-、S02NH-中选择；R12从卤素、NH2、N02、CN、OH、COOH、CONH2、C(=NH)NH2、S03H、S02NH2、S02CH3、OCH3、OCH2CH3、CF3中选择；R8和R9包括一个或多个独立选择的溶解基团，从i）中性亲水基团，ii）可离子化的有机酸，iii）可离子化的有机碱，iv）提供共价或非共价附着或结合到固相或不动的受体的化学功能或基团或其组合中选择；R4、R5和R6分别独立选择自H和R10，或R4到R6中的两个被连接形成含有一个或多个额外氧或氮原子的环醚或胺。该化合物可用于治疗由AKT、Aurora激酶、BCR-ABL、CDK、FLT、GSK3、IKK、JAK、MAPK、PDGF、PI3K、PKA、PKB、PKC、PLK、Src和VEGF家族酶中选择的一个或多个酶介导的疾病，或用于治疗癌症或其他增生性疾病，或用于抑制癌细胞的生长，或用于诱导人类或动物主体中癌细胞的凋亡。
• COMPOUNDS FOR TREATING PROLIFERATIVE DISORDERS
  申请人：Wang Shudong

  公开号：US20130190325A1

  公开（公告）日：2013-07-25

  A compound of formula (I) or a pharmaceutically acceptable salt or solvate or physiologically hydrolysable, solubilising or immobilisable derivative thereof; wherein: any one or two of X., X2 and X3 is a N atom and the remaining two or one of X 1 , X 2 and X 3 are independently CR 13 ; Y is selected from SO 2 and SO; R 1 , R 2 , R 3 , and R 7 and the one or two R 13 groups are each independently selected from H and R 10 , R 10 is selected from R 8 , alkyl, aryl, heteroaryl and combinations of two or more thereof and combinations with one or more R 9 , or R 10 is one or more moieties R 11 Sinking one or more alkyl, alkoxy, aryl, heteroaryl or R 8 or R 9 groups or combinations thereof, directly or via a moiety selected from alkylene, arylene, heteroarylene or combinations thereof, wherein alkyl, aryl, heteroaryl groups or moieties thereof may be substituted with one or more groups R 12 , or R 10 is selected from a group R 12 ; R 11 is selected from 0-, N—, NH—, N═C, CO—, C00-, CON—, CONH—, S0 2 -, S0 2 N—, S0 2 NH—; R 12 is selected from halogen, NH 2 , N0 2 , CN, OH, COOH, CONH 2 , C(═NH)NH 2 , S0 3 H, S0 2 NH 2 , S0 2 CH 3 , OCH 3 , OCH 2 CH 3 , CF 3 ; R 8 and R 9 comprise one or more solubilising moieties independently chosen from i) neutral hydrophilic groups, ii) ionisable organic acids, iii) ionisable organic bases, iv} chemical functions or moieties providing covalent or non-covalent attachment or binding to a solid phase or an immobile receptor and combinations thereof; R 4 , R 5 and R 6 are each independently selected from H and R 10 , or two of R 4 to R 6 are linked to form a cyclic ether or amine containing one or more additional oxygen or nitrogen atoms. The compound may be used for treating a condition mediated by one or more enzymes selected from AKT, Aurora kinase, BCR-ABL, CDK, FLT, GSK3, IKK, JAK, MAPK, PDGF, PI3K, PKA, PKB, PKC, PLK, Src and VEGF family enzymes, or for treating cancer or other proliferative disorder, or for inhibiting growth of cancer cells, or for inducing apoptosis of cancer cells, in a human or animal subject.

  公式（I）的化合物，或其药学上可接受的盐或溶剂或生理水解、溶解或固定化衍生物；其中：X、X2和X3中的任意一个或两个是N原子，其余两个或一个是独立的CR13；Y从SO2和SO中选择；R1、R2、R3和R7以及一个或两个R13基团各自独立地选择自H和R10，R10从R8、烷基、芳基、杂环芳基和两种或两种以上的组合以及与一个或多个R9的组合中选择，或者R10是一个或多个基团R11，其中每个基团R11包含一个或多个烷基、烷氧基、芳基、杂环芳基或R8或R9基团或其组合，直接或通过选择自烷基、芳基、杂环芳基或其组合的基团连接，其中烷基、芳基、杂环芳基基团或其基团可以被一个或多个基团R12取代，或者R10从一个基团R12的群中选择；R11从0-、N-、NH-、N═C、CO-、C00-、CON-、CONH-、S02-、S02N-、S02NH-中选择；R12从卤素、NH2、N02、CN、OH、COOH、CONH2、C（═NH）NH2、S03H、S02NH2、S02CH3、OCH3、OCH2CH3、CF3中选择；R8和R9各自包括一个或多个溶解化基团，独立地选择自i）中性亲水基团、ii）可离子化有机酸、iii）可离子化有机碱、iv）化学功能或基团，提供共价或非共价的固定或结合到固定相或不动的受体上，以及它们的组合；R4、R5和R6各自独立地选择自H和R10，或者R4到R6中的两个被连接形成含有一个或多个额外氧或氮原子的环醚或胺。该化合物可用于治疗由AKT、Aurora激酶、BCR-ABL、CDK、FLT、GSK3、IKK、JAK、MAPK、PDGF、PI3K、PKA、PKB、PKC、PLK、Src和VEGF家族酶中的一个或多个酶介导的疾病，或用于治疗癌症或其他增生性疾病，或用于抑制癌细胞的生长，或用于诱导癌细胞凋亡，在人类或动物主体中。
• Compounds for treating proliferative disorders
  申请人：Wang Shudong

  公开号：US08829003B2

  公开（公告）日：2014-09-09

  A compound of formula (I) or a pharmaceutically acceptable salt or solvate or physiologically hydrolysable, solubilizing or immobilizable derivative thereof; wherein: any one or two of X., X2 and X3 is a N atom and the remaining two or one of X1, X2 and X3 are independently CR13; Y is selected from SO2 and SO; R1, R2, R3, and R7 and the one or two R13 groups are each independently selected from H and R10, R10 is selected from R8, alkyl, aryl, heteroaryl and combinations of two or more thereof and combinations with one or more R9, or R10 is one or more moieties R11 Sinking one or more alkyl, alkoxy, aryl, heteroaryl or R8 or R9 groups or combinations thereof, directly or via a moiety selected from alkylene, arylene, heteroarylene or combinations thereof, wherein alkyl, aryl, heteroaryl groups or moieties thereof may be substituted with one or more groups R12, or R10 is selected from a group R12; R11 is selected from 0-, N—, NH—, N═C, CO—, C00-, CON—, CONH—, S02-, S02N—, S02NH—; R12 is selected from halogen, NH2, N02, CN, OH, COOH, CONH2, C(═NH)NH2, S03H, S02NH2, S02CH3, OCH3, OCH2CH3, CF3; R8 and R9 comprise one or more solubilizing moieties independently chosen from i) neutral hydrophilic groups, ii) ionisable organic acids, iii) ionisable organic bases, iv} chemical functions or moieties providing covalent or non-covalent attachment or binding to a solid phase or an immobile receptor and combinations thereof; R4, R5 and R6 are each independently selected from H and R10, or two of R4 to R6 are linked to form a cyclic ether or amine containing one or more additional oxygen or nitrogen atoms. The compound may be used for treating a condition mediated by one or more enzymes selected from AKT, Aurora kinase, BCR-ABL, CDK, FLT, GSK3, IKK, JAK, MAPK, PDGF, PI3K, PKA, PKB, PKC, PLK, Src and VEGF family enzymes, or for treating cancer or other proliferative disorder, or for inhibiting growth of cancer cells, or for inducing apoptosis of cancer cells, in a human or animal subject.

  式（I）的化合物，或其药学上可接受的盐、溶剂或生理水解、溶解或固定衍生物；其中：X、X2和X3中的任意一个或两个是N原子，剩下的两个或一个是独立的CR13；Y选自SO2和SO；R1、R2、R3、R7和一个或两个R13基团各自独立地选自H和R10，R10选自R8、烷基、芳香族、杂环芳香族和两种或以上的组合物以及与一个或多个R9的组合物，并且R10是一个或多个基团R11，其中每个基团R11包括一个或多个烷基、烷氧基、芳香族、杂环芳香族或R8或R9基团或其组合物，直接或通过选自烷基、芳基、杂环芳基或其组合物的基团与之相连，其中烷基、芳香族、杂环芳香族基团或其基团可以被一个或多个基团R12取代，或R10选自一个基团R12；R11选自0-、N-、NH-、N═C、CO-、C00-、CON-、CONH-、S02-、S02N-、S02NH-；R12选自卤素、NH2、N02、CN、OH、COOH、CONH2、C(═NH)NH2、S03H、S02NH2、S02CH3、OCH3、OCH2CH3、CF3；R8和R9包括一个或多个独立选择的增溶基团，包括i）中性亲水基团，ii）离子性有机酸，iii）离子性有机碱，iv）提供共价或非共价固定或结合到固相或不动的受体的化学功能或基团以及其组合物；R4、R5和R6各自独立地选自H和R10，或其中的两个被连接成含有一个或多个额外氧原子或氮原子的环醚或胺。该化合物可用于治疗由AKT、Aurora激酶、BCR-ABL、CDK、FLT、GSK3、IKK、JAK、MAPK、PDGF、PI3K、PKA、PKB、PKC、PLK、Src和VEGF家族酶中的一个或多个酶介导的疾病，或用于治疗癌症或其他增殖性疾病，或用于抑制癌细胞的生长，或用于诱导人或动物主体中癌细胞的凋亡。
• US8829003B2
  申请人：——

  公开号：US8829003B2

  公开（公告）日：2014-09-09
• Discovery of (<i>E</i>)-3-((Styrylsulfonyl)methyl)pyridine and (<i>E</i>)-2-((Styrylsulfonyl)methyl)pyridine Derivatives as Anticancer Agents: Synthesis, Structure–Activity Relationships, and Biological Activities
  作者：Tiangong Lu、Aik Wye Goh、Mingfeng Yu、Julian Adams、Frankie Lam、Theodosia Teo、Peng Li、Ben Noll、Longjin Zhong、Sarah Diab、Osama Chahrour、Anran Hu、Abdullahi Y. Abbas、Xiangrui Liu、Shiliang Huang、Christopher J. Sumby、Robert Milne、Carol Midgley、Shudong Wang

  DOI：10.1021/jm4019614

  日期：2014.3.27

  exposure for biological activity in patients. We have identified two novel series of styrylsulfonyl-methylpyridines. Lead compounds 8, 9a, 18 and 19a are highly potent mitotic inhibitors and selectively cytotoxic to cancer cells. Impressively, these compounds possess excellent pharmaceutical properties and two lead drug candidates 9a and 18 demonstrated antitumor activities in animal models.

  ON01910.Na是一种高效的抗癌剂，可诱导有丝分裂阻滞和细胞凋亡。ON01910在癌症患者中的临床研究显示出疗效以及令人印象深刻的安全性。尽管ON01910对癌细胞具有高活性，但口服利用率低，需要连续静脉输注或多克剂量才能确保患者充分的药物暴露以实现其生物学活性。我们已经确定了两个新颖的苯乙烯基磺酰基-甲基吡啶系列。铅化合物8，图9A，18和19A是高度有效的有丝分裂抑制剂和选择性的细胞毒性，以癌细胞。令人印象深刻的是，这些化合物具有出色的药物特性和两个候选候选药物9a还有18个在动物模型中证明了抗肿瘤活性。