2,5,8,11,14,17-docosahexenoic acid | 1240669-34-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,5,8,11,14,17-docosahexenoic acid
• 英文别名: 2,5,8,11,14,17-Docosahexenoic acid；docosa-2,5,8,11,14,17-hexaenoic acid
• CAS: 1240669-34-4
• 化学式: C₂₂H₃₂O₂
• 分子量: 328.495
• InChiKey: WKPMFJMCBZGMMZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  24
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,5,8,11,14,17-docosahexenoic acid 、 2-(11H-benzo[a]carbazol-11-yl)ethyl 4-methylbenzenesulfonate 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.58h， 生成
  参考文献：
  名称：

  Analysis and Evaluation of Fatty Acid in Rattan Tea by Highly Selective and Sensitive HPLC- FLD-MS Method Coupled with Pre-Column Fluorescent Labeling

  摘要：

  藤椰茶作为预防和治疗许多慢性疾病的最有前景的膳食补充剂之一，受到广泛关注。游离脂肪酸在人体中作为必需营养素起着重要作用。首次使用对甲苯磺酸2-(萘-1-基-苯氨基)-乙基酯作为前柱荧光衍生化试剂，利用高效液相色谱-大气化学电离质谱（APCI/MS）技术，研究了藤椰茶中31种游离脂肪酸的含量。结果表明，低的检出限（0.52-1.53 ng mL-1）为游离脂肪酸的微量分析和评估提供了保障。实验的回收率在88.9%-103.6%之间。本研究的结果显示，藤椰茶中游离脂肪酸含量最高的月份是四月。共发现了13种游离脂肪酸，其中包括生命必需的C18:2w6、C18:3w3、w6和C20:4w6。所开发的方法展示了系统检测药用植物生物活性成分的强大潜力。

  DOI：

  10.14233/ajchem.2014.15335

文献信息

• <i>Trigonella foenum</i> ‐ <i>graecum</i> L. Seed Oil Obtained by Supercritical CO ₂ Extraction
  作者：Renming Yang、Honglun Wang、Nianhua Jing、Chenxu Ding、Yourui Suo、Jinmao You

  DOI：10.1007/s11746-012-2123-x

  日期：2012.12

  AbstractSupercritical CO2 extraction (SC‐CO2) of fenugreek (Trigonella foenum‐graecum L.) seed oil and its chemical composition and antioxidant activity were investigated. A central composite design combined with response surface methodology was used to study extraction conditions including pressure, temperature, and time. The optimum extraction conditions were 28.5 MPa extraction pressure, 41 °C extraction temperature, and 118 min extraction time, where 3.78 % yield was predicted. Fenugreek seed oil extracted under optimum conditions by SC‐CO2 was mainly composed of 28.3 % C18:3, 33.45 % C18:2, 9.89 % C16, 8.1 % C18:1, 3.7 % C18, 0.71 % C20, and 0.61 % C22. The fenugreek oil was rich in unsaturated fatty acids (nearly 70 % of the total fatty acids), and polyunsaturated fatty acids accounted for 61.42 % (mass percentage) of the total amount. The 2,2‐diphenyl‐1‐picrylhydrazyl radical‐scavenging activity increased from 12.5 to 88.4 % when the concentration was increased from 1 to 12 mg/ml. The reducing power of the seed oil was concentration‐dependent. The antioxidant activity of the supercritical fluid extraction extract was superior to those obtained by Soxhlet extraction.