N-(1-丁氧基乙基)-N-甲基甲苯-4-磺酰胺 | 100967-39-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-(1-丁氧基乙基)-N-甲基甲苯-4-磺酰胺
• 英文名称: N-(1-butoxy-ethyl)-N-methyl-toluene-4-sulfonamide
• 英文别名: N-(1-Butoxy-aethyl)-N-methyl-toluol-4-sulfonamid；N-(1-butoxyethyl)-N,4-dimethylbenzenesulfonamide
• CAS: 100967-39-3
• 化学式: C₁₄H₂₃NO₃S
• 分子量: 285.408
• InChiKey: YFDBVCGFOIOLOI-UHFFFAOYSA-N

物化性质

• 沸点：
  160-164 °C(Press: 5 Torr)
• 密度：
  1.095±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  55
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-(1-丁氧基乙基)-N-甲基甲苯-4-磺酰胺 生成 N-乙烯基-N,4-二甲基苯磺酰胺
  参考文献：
  名称：

  Reaction of Vinyl Ethers with Acidic Imino Compounds. A New Synthesis of Some N-Vinyl Imides

  摘要：

  DOI：

  10.1021/jo01099a008
• 作为产物：
  描述：

  乙烯基正丁醚 、 N-甲基对甲苯磺酰胺 在 盐酸 作用下， 生成 N-(1-丁氧基乙基)-N-甲基甲苯-4-磺酰胺
  参考文献：
  名称：

  Reaction of Vinyl Ethers with Acidic Imino Compounds. A New Synthesis of Some N-Vinyl Imides

  摘要：

  DOI：

  10.1021/jo01099a008

文献信息

• Reaction of Vinyl Ethers with Acidic Imino Compounds. A New Synthesis of Some N-Vinyl Imides
  作者：JUNJI FURUKAWA、AKIRA ONISHI、TEIJI TSURUTA

  DOI：10.1021/jo01099a008

  日期：1958.5
• Administration of glutathione in patients with type 2 diabetes mellitus increases the platelet constitutive nitric oxide synthase activity and reduces PAI-1
  作者：V. Martina、G. A. Bruno、E. Zumpano、C. Origlia、L. Quaranta、G. P. Pescarmona

  DOI：10.1007/bf03343806

  日期：2001.1

  Several studies suggest that nitric oxide (NO) production is impaired in diabetes mellitus. Reduced levels of NO could contribute to cardiovascular mortality. Furthermore, NO synthesis is impaired in glutathione (GSH)-depleted human umbilical vein endothelial cells and GSH is reduced in patients with type 2 diabetes mellitus (T2DM). We tested the hypothesis that treatment with GSH may improve platelet constitutive NO sinthase (cNOS) activity in patients with T2DM. Fifteen patients with T2DM underwent a treatment with GSH 600 mg/day im for 10 days. With respect to the basal values on the 10(th) day of treatment, the red blood cell GSH concentration and platelets cNOS increased (1.4+/-0.1 vs 1.9+/-0.1 mu mol/10(10) RBC, p<0.001 and 0.7+/-0.1 vs 2.9+/-0.2 fmol.min(-1).10(-9) PLTs, p<0.001, respectively) and the plasma PAI-1 levels diminished (81.4+/-3.7 vs 68.7+/-4.0 ng/ml, p<0.002). A negative correlation between the cNOS and the PAI-1 was found on the basal values. After a wash-out of 30 days the values of red blood cell GSH concentration, platelet cNOS activity and PAI-1 Ag returned to the basal levels. These data suggest that the administration of GSH, in patients with T2DM, is able to improve platelet cNOS activity together with a reduction of PAI-1. (C) 2001, Editrice Kurtis.