N-(1-氧代十六烷基)-BETA-丙氨酰-L-组氨酸 | 324755-72-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 肽模拟物
• 中文名称: N-(1-氧代十六烷基)-BETA-丙氨酰-L-组氨酸
• 中文别名: N-(1-氧代十六烷基)-beta-丙氨酰-L-组氨酸
• 英文名称: Palmitoyl carnosine
• 英文别名: (2S)-2-[3-(hexadecanoylamino)propanoylamino]-3-(1H-imidazol-5-yl)propanoic acid
• CAS: 324755-72-8
• 化学式: C₂₅H₄₄N₄O₄
• 分子量: 464.6
• InChiKey: LNXLHAWHHNDIDC-QFIPXVFZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  33
• 可旋转键数：
  21
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  124
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• [EN] ACTIVE INGREDIENT COMPRISING A MIXTURE OF UNSATURATED DICARBOXYLIC FATTY ACIDS, COMPOSITIONS COMPRISING SAID INGREDIENT AND COSMETIC OR DERMATOLOGICAL USES<br/>[FR] PRINCIPE ACTIF COMPRENANT UN MÉLANGE D'ACIDES GRAS DICARBOXYLIQUES INSATURÉS, COMPOSITIONS COMPRENANT LEDIT PRINCIPE, ET UTILISATIONS COSMÉTIQUES OU DERMATOLOGIQUES
  申请人：SEDERMA SA

  公开号：WO2016012973A1

  公开（公告）日：2016-01-28

  The ingredient comprises a mixture of unsaturated dicarboxylic acids comprising the Z and E isomers of at least one mono-unsaturated dicarboxylic C12-C24 acid, the concentration of the E isomer being of at least 25% by weight based on the total weight of Z and E isomers The ingredient can be used to form cosmetic or dermatological compositions, in particular for lightening the skin, improving the clarity and unification of the skin complexion.80

  该成分包含一种不饱和二羧酸混合物，包括至少一种单不饱和二羧酸C12-C24酸的Z和E异构体，其中E异构体的浓度至少为总Z和E异构体重量的25%。该成分可用于制备化妆品或皮肤科学配方，特别是用于美白皮肤，改善皮肤肤色的清晰度和统一性。
• Lipo-Phosphated or Lipo-Sulphated Compound, Compositions Comprising It and Topical Uses Thereof
  申请人：Fournial Arnaud

  公开号：US20130004439A1

  公开（公告）日：2013-01-03

  The compound according to the invention has the following developed formula IX: wherein: X=PO(OH) 2 ; SO 2 (OH); PO(OH)(Xaa) m or SO 2 (Xaa) m ; A=H; OH; NH 2 or akyl (1-6C); n=1 to 4; Y=—CO—OR 2 ; —CO—NR 3 R 4; —O—CO—R 2; —C═CR 2 ; R 2 =an alkyl, aryl, aralkyl, acyl, sulfonyl, sugar or alkoxy chain of 1 to 24 carbon atoms, linear, branched or cyclic, with or without substitutions, saturated or not, hydroxylated or not, sulfurated or not; R 5 =OH, O-alk (1-6C), (Xaa) m , NH 2 or NH-alkyl(1-6C); Xaa=peptide of m aminoacids Xaa with m from 1 to 10; The compound is preferably phosphated, obtained from malic acid and having the following developed formula: A cosmetic composition comprising the compound of the present invention can improve the general condition of the skin, for example hydration, lightening and mechanical properties.

  本发明所述化合物的结构式为IX，具体如下：其中：X=PO(OH)2；SO2(OH)；PO(OH)(Xaa)m或SO2(Xaa)m；A=H；OH；NH2或烷基(1-6C)；n=1至4；Y=—CO—OR2；—CO—NR3R4；—O—CO—R2；—C═CR2；R2=1至24个碳原子的直链、支链或环状的烷基、芳基、芳基烷基、酰基、磺酰基、糖基或烷氧基，可以有或没有取代基，可以是饱和或不饱和的，可以是羟基化或非羟基化的，可以是硫化或非硫化的；R5=OH、O-烷基(1-6C)、(Xaa)m、NH2或NH-烷基(1-6C)；Xaa=由m个氨基酸Xaa组成的肽，其中m为1至10。该化合物最好是磷酸化的，由苹果酸得到，具有以下结构式：本发明的化妆品组合物可以改善皮肤的总体状况，例如水合、美白和力学性能。
• Novel Molecules dervied from noraporphine
  申请人：Lintner Karl

  公开号：US20060110413A1

  公开（公告）日：2006-05-25

  The invention concerns novel molecules derived from noraporphine, as well as cosmetic and dermopharmaceutical compositions containing one or several of said derivatives, alone or combined with a plant extract, in particular glaucium flavum, and particularly preparations for reducing pigmentation, with anti-ageing effect or for slimming.

  本发明涉及从莫尔吖啶衍生的新分子，以及含有该衍生物中的一种或几种的化妆品和皮肤药物组合物，单独或与植物提取物，特别是黄波罗花，特别是用于减少色素沉着，具有抗衰老作用或减肥的制剂。
• Cosmetic compositions comprising at least one peptide with at least one immobilized aromatic cycle
  申请人：Sederma

  公开号：EP2510982A1

  公开（公告）日：2012-10-17

  Topical cosmetic use as a whitening active ingredient of at least one peptide, comprising at least one immobilized aromatic cycle and having the general formula (I): A- (Xa)m-Xc-(Xb)n-B. The invention also discloses a cosmetic composition comprising at least said peptide and a method of decreasing skin pigmentation, whitening or lightening human skin, comprising a topical application of said composition.

  作为美白活性成分的至少一种肽的局部化妆品用途，该肽包含至少一个固定的芳香族循环并具有通式 (I)：A-(Xa)m-Xc-(Xb)n-B。本发明还公开了一种至少包含上述多肽的化妆品组合物，以及一种减少皮肤色素沉着、美白或淡化人体皮肤的方法，包括局部施用上述组合物。
• COMPOUNDS, IN PARTICULAR PEPTIDES, COMPOSITIONS COMPRISING THEM AND COSMETIC AND DERMOPHARMACEUTICAL USES
  申请人：SEDERMA

  公开号：EP3744729A1

  公开（公告）日：2020-12-02

  The present invention relates to the cosmetic and dermopharmaceutical fields. It concerns compounds having the following formula II :         R1-(AA)n-R2     (SEQ ID NO 1 to SEQ ID NO 7) wherein: AA is selected from an amino acid, an amino acid derivative and an amino acid analogue ; n=1 to 10, when n ≥ 2, the AA can be different and the bonds being of peptidic or peptoidic type; R1 is either an H or a lipophilic chain, R2 is either an OH or a lipophilic chain, characterised in that the AA or when n>1 at least one of the AA comprise at least one sulfur atom in an oxygenated form, preferably a dioxygenated form. More preferably, AA is a dioxygenated SO2 methionine. Results on the activity of the compounds are obtained and on the general state of the skin and its appendages, especially via the stimulation of extracellular matrix components.

  本发明涉及化妆品和皮肤药物领域。 它涉及具有下式 II ： R1-(AA)n-R2 (SEQ ID NO 1 至 SEQ ID NO 7) 其中 AA 选自氨基酸、氨基酸衍生物和氨基酸类似物； n=1至10，当n≥2时，AA可以不同，键为肽键或类肽键； R1 是 H 或亲脂链、 R2 是羟基或亲脂性链、 其特征在于 AA 或当 n>1 时，至少一个 AA 包含至少一个含氧硫原子，最好是二氧 化硫原子。更优选的是，AA 是二氧化的 SO2 蛋氨酸。 通过对细胞外基质成分的刺激，可以获得化合物的活性和皮肤及其附属物的总体状态。