3-(6-methoxypyridin-3-yl)-N,N-dimethylpropanamide | 1174066-63-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(6-methoxypyridin-3-yl)-N,N-dimethylpropanamide
• CAS: 1174066-63-7
• 化学式: C₁₁H₁₆N₂O₂
• 分子量: 208.26
• InChiKey: WWWOVIMSVJUBHA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  42.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-氯-2-甲氧基吡啶 、 N,N-dimethyl-3-(trifluoro-λ⁴-boranyl)propanamide potassium salt 在 2-双环己基膦-2',6'-二甲氧基联苯 、 palladium diacetate 、 potassium carbonate 作用下， 以 水 、 甲苯 为溶剂， 反应 14.0h， 以87%的产率得到3-(6-methoxypyridin-3-yl)-N,N-dimethylpropanamide
  参考文献：
  名称：

  Use of Potassium β-Trifluoroborato Amides in Suzuki−Miyaura Cross-Coupling Reactions

  摘要：

  Potassium beta-trifluoroborato amides were prepared and used as successful partners in Suzuki-Miyaura reactions with various aryl chlorides, including electron-rich and electron-poor derivatives, as well as several heteroaryl chloride partners.

  DOI：

  10.1021/jo900968h

文献信息

• 2-CYANOPHENYL FUSED HETEROCYCLIC COMPOUNDS, AND COMPOSITIONS AND USES THEREOF
  申请人：Renovis, Inc.

  公开号：EP2139334A1

  公开（公告）日：2010-01-06
• [EN] 2-CYANOPHENYL FUSED HETEROCYCLIC COMPOUNDS, AND COMPOSITIONS AND USES THEREOF<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES FUSIONNÉS DE 2-CYANOPHÉNYLE, COMPOSITIONS ET UTILISATIONS DE CEUX-CI
  申请人：RENOVIS INC

  公开号：WO2008130481A1

  公开（公告）日：2008-10-30

  [EN] Fused heterocyclic compounds are provided according to formula (1): where R¹, R², R³, and m are as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.
  [FR] L'invention concerne des composés hétérocycliques fusionnés formés selon la formule (1) : où R1, R2, R3 et m sont définis ici. Les composés formés et leurs compositions pharmaceutiques sont utiles pour la prévention et le traitement d'une variété d'affections chez les mammifères, y compris les humains, comprenant à titre d'exemple non limitatif, la douleur, l'inflammation, les troubles cognitifs, l'anxiété, la dépression et autres.
• Use of Potassium β-Trifluoroborato Amides in Suzuki−Miyaura Cross-Coupling Reactions
  作者：Gary A. Molander、Ludivine Jean-Gérard

  DOI：10.1021/jo900968h

  日期：2009.8.7

  Potassium beta-trifluoroborato amides were prepared and used as successful partners in Suzuki-Miyaura reactions with various aryl chlorides, including electron-rich and electron-poor derivatives, as well as several heteroaryl chloride partners.