N-(1-甲酰胺基乙基)甲酰胺 | 20602-52-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: N-(1-甲酰胺基乙基)甲酰胺
• 英文名称: 1,1-Bis(formamido)ethane
• 英文别名: ethylidene bis-formamide；ethylidene bisformamide；Formamide, N,N'-ethylidenebis-；N-(1-formamidoethyl)formamide
• CAS: 20602-52-2
• 化学式: C₄H₈N₂O₂
• 分子量: 116.12
• InChiKey: OYFXZONQZDQAMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2924199090

反应信息

• 作为反应物：
  描述：

  N-(1-甲酰胺基乙基)甲酰胺 生成 N-乙烯基甲酰胺
  参考文献：
  名称：

  Process for preparing n-vinyl amides

  摘要：

  具有一般结构式CH.sub.2.dbd.CH--NHCOR.sup.1的N-乙烯基酰胺，其中R.sup.1是氢，C.sub.1到C.sub.6烷基或C.sub.6-C.sub.9芳基或取代芳基，是通过裂解具有以下一般结构式的羧酸酰胺形成的：##STR1##其中R.sup.1如上所述，R.sup.2是C.sub.1到C.sub.9烷氧基，羧基或羧酰胺基团。所述羧酸酰胺在多孔的氢抽提催化剂的存在下，在加热到约150℃至350℃的温度下裂解。

  公开号：

  US04942259A1
• 作为产物：
  描述：

  乙醛 、 甲酰胺 生成 N-(1-甲酰胺基乙基)甲酰胺
  参考文献：
  名称：

  DAWSON, D. J.;OTTESON, K. M.

  摘要：

  DOI：

文献信息

• Methods of making and using surfactant polymers
  申请人：Marchant E. Roger

  公开号：US20050008603A1

  公开（公告）日：2005-01-13

  Comblike, surfactant polymers for changing the surface properties of biomaterials are provided. Such surfactant polymers comprise a polymeric backbone of repeating monomeric units having functional groups for coupling with side chains, a plurality of hydrophobic side chains linked to said backbone via the functional groups, and a plurality of hydrophilic side chains linked to said backbone via the functional groups. The hydrophobic side chains comprise an alkyl group comprising from 2 to 18 methylene groups. The alkyl groups are linked to the polymeric backbone through ester linkages, secondary amine linkages, or, preferably, amide linkages. The hydrophilic side chain is selected from the group consisting of: a neutral oligosaccharide, which, preferably, has weight average molecular weight of less than 7000; a charged oligosaccharide, preferably a negatively charged oligosaccharide having a weight average molecular weight of less than 10,000; an oligopeptide of from about 3 to about 30 amino acid residues, said oligopeptide having an amino acid sequence which interacts with protein receptors on the surface of cells; and combinations thereof. Methods of making the surfactant polymers and using the surfactant polymers to alter the surface properties of a biomaterial are also provided.

  提供了用于改变生物材料表面性质的类似梳子的表面活性聚合物。这种表面活性聚合物包括具有用于与侧链偶联的功能基团的重复单体单位的聚合骨架，通过功能基团连接到该骨架的多个疏水侧链，以及通过功能基团连接到该骨架的多个亲水侧链。疏水侧链包括包含从2到18个亚甲基团的烷基团。烷基团通过酯键、次胺键或者更好地，酰胺键连接到聚合骨架上。亲水侧链选自以下组合中的一种：中性寡糖，最好的情况下，其重均分子量小于7000；带电寡糖，最好是重均分子量小于10000的带负电寡糖；由大约3到大约30个氨基酸残基组成的寡肽，该寡肽具有与细胞表面蛋白受体相互作用的氨基酸序列；以及它们的组合。还提供了制备表面活性聚合物和使用表面活性聚合物改变生物材料表面性质的方法。
• Reactions of ethylidene diacetate: Formation of N-vinylamide precursors ethylidene bisacetamide and ethylidene bisformamide
  作者：John J. Rabasco、Francis J. Waller

  DOI：10.1016/s0040-4039(97)01089-7

  日期：1997.7

  Ethylidene diacetate (EDA) reacts with formamide or acetamide under stoichiometric base or catalytic Lewis acid conditions to afford the corresponding ethylidene bisamides and N-vinylamides. Sn(OAc)2 afforded an overall 82.6% selectivity to the desired acetamide derivatives. Sn(OAc)2 and Zn(OAc)2 facilitate amide attack at the tertiary carbon of EDA.

  亚乙二乙酸酯（EDA）在化学计量的碱或催化的路易斯酸条件下与甲酰胺或乙酰胺反应，得到相应的亚乙基双酰胺和N-乙烯基酰胺。Sn（OAc）2对所需乙酰胺衍生物的总选择性为82.6％。Sn（OAc）2和Zn（OAc）2促进酰胺对EDA叔碳的攻击。
• Synthesis of fluorine-containing aliphatic gem-dinitramines
  作者：John Adams Young、John A. Krimmel、Josef J. Schmidt-Collerus、George E. Bohner、Donald N. Gray

  DOI：10.1021/jo00801a025

  日期：1971.1
• PARRIS, GENE E.;ARMON, JOHN N.
  作者：PARRIS, GENE E.、ARMON, JOHN N.

  DOI：——

  日期：——
• Process for preparing n-vinyl amides
  申请人：Air Products and Chemicals, Inc.

  公开号：US04942259A1

  公开（公告）日：1990-07-17

  N-vinyl amides having the general structural formula: CH.sub.2 .dbd.CH--NHCOR.sup.1 wherein R.sup.1 is hydrogen, a C.sub.1 to C.sub.6 alkyl group or C.sub.6 -C.sub.9 aryl or substituted aryl group, are formed by cracking carboxylic acid amides having the general structure formula: ##STR1## wherein R.sup.1 is as described above, and R.sup.2 is a C.sub.1 to C.sub.9 alkoxy, carboxy or carboxamide group. Said carboxylic acid amides are cracked by heating, to a temperature of about 150.degree.-350.degree. C., in the presence of a porous, hydrogen-abstracting catalyst.

  具有一般结构式CH.sub.2.dbd.CH--NHCOR.sup.1的N-乙烯基酰胺，其中R.sup.1是氢，C.sub.1到C.sub.6烷基或C.sub.6-C.sub.9芳基或取代芳基，是通过裂解具有以下一般结构式的羧酸酰胺形成的：##STR1##其中R.sup.1如上所述，R.sup.2是C.sub.1到C.sub.9烷氧基，羧基或羧酰胺基团。所述羧酸酰胺在多孔的氢抽提催化剂的存在下，在加热到约150℃至350℃的温度下裂解。