2-Hydroxypropyl-b-cyclodextrin

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Hydroxypropyl-b-cyclodextrin
• 英文别名: 1-[[36,37,38,39,40,41,42,43,44,45,46,47,48,49-tetradecakis(2-hydroxypropoxy)-10,15,20,25,30,35-hexakis(2-hydroxypropoxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontan-5-yl]methoxy]propan-2-ol
• 化学式: C₁₀₅H₁₉₆O₅₆
• 分子量: 2354.6
• InChiKey: DCQLZTSRKLWEAB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -9
• 重原子数：
  161
• 可旋转键数：
  70
• 环数：
  21.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  748
• 氢给体数：
  21
• 氢受体数：
  56

文献信息

• Compositions for Nasal Administration of Phenothiazines
  申请人：GUY David

  公开号：US20100215730A1

  公开（公告）日：2010-08-26

  Provided herein are pharmaceutical compositions comprising phenothiazines or derivatives thereof that are formulated for nasal administration. Also provided herein are methods of utilizing the same.

  本文提供了一种含有苯并噻唑或其衍生物的药物组合物，该药物组合物适用于鼻腔给药。本文还提供了使用该药物组合物的方法。
• CONTROLLED RELEASE ANTIMICROBIAL COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS
  申请人：LICHTER Jay

  公开号：US20100036000A1

  公开（公告）日：2010-02-11

  Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with antimicrobial agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).

  本文公开了用抗微生物药物组合物和制剂治疗耳疾或病症的组合物和方法，通过将这些组合物和制剂直接应用于或通过灌注进入目标耳结构，局部治疗患有耳疾或病症的个体。
• AMINE DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS
  申请人：Scott Ian L.

  公开号：US20120041038A1

  公开（公告）日：2012-02-16

  Provided are amine derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.

  本发明提供了氨基衍生物化合物、其制药组合物以及使用所述化合物和组合物治疗眼科疾病和疾患的方法，例如老年性黄斑变性和Stargardt病。
• COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS
  申请人：Scott Ian L.

  公开号：US20100113539A1

  公开（公告）日：2010-05-06

  Provided are compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.

  提供了化合物、药物组合物及其治疗眼科疾病和疾患的方法，例如年龄相关性黄斑退化和Stargardt病，使用上述化合物和组合物进行治疗。
• Controlled Release Antimicrobial Compositions and Methods for the Treatment of Otic Disorders
  申请人：Otonomy, Inc.

  公开号：US20150150793A1

  公开（公告）日：2015-06-04

  Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with antimicrobial agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).

  本文公开了一种使用抗微生物剂组合物和制剂局部治疗患有耳疾或状况的个体的方法和组合物，通过将这些组合物和制剂直接应用于或通过灌注进入目标耳结构。