2-(Dihydrogen phosphate) d-glucose

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(Dihydrogen phosphate) d-glucose
• 英文别名: (3,4,5,6-tetrahydroxy-1-oxohexan-2-yl) dihydrogen phosphate
• 化学式: C₆H₁₃O₉P
• 分子量: 260.14
• InChiKey: GBXZONVFWYCRPT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.5
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  165
• 氢给体数：
  6
• 氢受体数：
  9

文献信息

• [EN] THERAPEUTIC COMPOUNDS AND COMPOSITIONS<br/>[FR] COMPOSÉS ET COMPOSITIONS THÉRAPEUTIQUES
  申请人：AGIOS PHARMACEUTICALS INC

  公开号：WO2014139325A1

  公开（公告）日：2014-09-18

  Compounds of general formula (I) and compositions comprising compounds of general formula (I) that modulate pyruvate kinase are described herein. Also described herein are methods of using the compounds that modulate pyruvate kinase in the treatment of diseases.

  本文描述了一般式（I）化合物和包含调节丙酮酸激酶的一般式（I）化合物的组合物。本文还描述了利用调节丙酮酸激酶的这些化合物治疗疾病的方法。
• THERAPEUTIC COMPOUNDS AND COMPOSITIONS
  申请人：Cianchetta Giovanni

  公开号：US20140288081A1

  公开（公告）日：2014-09-25

  Compounds of general formula I: and compositions comprising compounds of general formula I that modulate pyruvate kinase are described herein. Also described herein are methods of using the compounds that modulate pyruvate kinase in the treatment of diseases.

  通式I的化合物： 以及包含调节丙酮酸激酶的通式I化合物的组合物在此处被描述。此外，在此处还描述了利用调节丙酮酸激酶的化合物治疗疾病的方法。
• [EN] THERAPEUTIC COMPOUNDS AND COMPOSITIONS AND THEIR USE AS PKM2 MODULATORS<br/>[FR] COMPOSÉS ET COMPOSITIONS THÉRAPEUTIQUES ET LEUR UTILISATION COMME MODULATEURS DE PKM2
  申请人：AGIOS PHARMACEUTICALS INC

  公开号：WO2014074848A1

  公开（公告）日：2014-05-15

  Compositions comprising compounds of general formula (I) that modulate pyruvate kinase are described herein. Also described herein are methods of using the compounds that modulate pyruvate kinase in the treatment of diseases.

  本文描述了包含通式（I）化合物的组合物，这些化合物调节丙酮酸激酶。本文还描述了利用这些调节丙酮酸激酶的化合物治疗疾病的方法。
• [EN] NOVEL PYRIDYLOXYACETYL TETRAHYDROISOQUINOLINE COMPOUNDS USEFUL AS NAMPT INHIBITORS<br/>[FR] NOUVEAUX COMPOSÉS DE PYRIDYLOXYACÉTYL TÉTRAHYDROISOQUINOLINE UTILES EN TANT QU'INHIBITEURS DE NAMPT
  申请人：LILLY CO ELI

  公开号：WO2015054060A1

  公开（公告）日：2015-04-16

  The present invention provides novel pyridyloxyacetyl tetrahydroisoquinoline compounds that inhibit NAMPT and may be useful in the treatment of cancer.

  本发明提供了一种新型的吡啶氧乙酰四氢异喹啉化合物，可以抑制NAMPT，并可能在癌症治疗中有用。
• Orthoester derivatives of crown ethers as carriers for pharmaceutical and diagnostic compositions
  申请人：ArisGen SA

  公开号：EP2332929A1

  公开（公告）日：2011-06-15

  This invention relates to A crown ether of formula (I) wherein m is 4, 5, 6, 7, or 8 and i is, independently for each occurrence, 1 or 2; at least one occurrence in the crown ether of R1, R2 and the carbon to which R1 and R2 are attached, said carbon being bound directly to an ether oxygen of formula (I), form together a group of formula (II) wherein L is a linker which is absent or selected from a covalent bond and (CR5R6)n, useful as carriers for pharmaceutical and diagnostic compositions.

  这项发明涉及一种式(I)的冠醚，其中m为4、5、6、7或8，i为每次出现时独立取1或2；在冠醚中至少有一个R1、R2和R1和R2附着的碳形成一个式(II)的基团，其中L是一个连接物，可以是缺席或选择自共价键和(CR5R6)n，用作药物和诊断组合物的载体。