2-Furan-2-ylmethyl-succinic acid 4-tert-butyl ester | 311803-90-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-Furan-2-ylmethyl-succinic acid 4-tert-butyl ester
• 英文别名: 2-(Furan-2-ylmethyl)-4-[(2-methylpropan-2-yl)oxy]-4-oxobutanoic acid
• CAS: 311803-90-4
• 化学式: C₁₃H₁₈O₅
• 分子量: 254.283
• InChiKey: GYROIPDWUIOHGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  76.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-Furan-2-ylmethyl-succinic acid 4-tert-butyl ester 在 Lindlar's catalyst sodium azide 、 dimethyl sulfide borane 、 TEA 、 氢气 、 三氟乙酸 作用下， 以 四氢呋喃 、 二氯甲烷 、 二甲基亚砜 、 乙酸乙酯 为溶剂， 生成 3-Aminomethyl-4-furan-2-yl-butyric acid
  参考文献：
  名称：

  Heteroaromatic side-chain analogs of pregabalin

  摘要：

  A series of heteroaromatic analogs of pregabalin has been identified that possess anticonvulsant activity in the DBA/2 mouse model. The methods of synthesis and preliminary pharmacology are discussed herein. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.06.090
• 作为产物：
  描述：

  methyl 3-(2-furyl)propionate 在 lithium hydroxide 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 异丙醇 为溶剂， 生成 2-Furan-2-ylmethyl-succinic acid 4-tert-butyl ester
  参考文献：
  名称：

  Heteroaromatic side-chain analogs of pregabalin

  摘要：

  A series of heteroaromatic analogs of pregabalin has been identified that possess anticonvulsant activity in the DBA/2 mouse model. The methods of synthesis and preliminary pharmacology are discussed herein. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.06.090

文献信息

• 3-heteroarylalkyl substituted gaba analogs
  申请人：Warner-Lambert Company

  公开号：US06710190B1

  公开（公告）日：2004-03-23

  The invention is a novel series of compounds which are useful in the treatment of epilepsy, faintness attacks, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorders such as irritable bowel syndrome (IBS), and inflammation, especially arthritis. A pharmaceutical composition containing a compound of the invention as well as methods of preparing the compounds and novel intermediates useful in the preparation of the final compounds are included.

  这项发明是一种新型化合物系列，可用于治疗癫痫、晕厥发作、神经退行性疾病、抑郁症、焦虑、恐慌、疼痛、神经病理性疾病、肠道紊乱症（IBS）以及炎症，尤其是关节炎。包含一种该发明化合物的药物组合物，以及制备这些化合物的方法和在制备最终化合物中有用的新型中间体。
• COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERS
  申请人：Hoveyda Hamid

  公开号：US20110230477A1

  公开（公告）日：2011-09-22

  The present invention is directed to novel compounds of formula (I) and their use in treating metabolic diseases.

  本发明涉及式（I）的新化合物及其在治疗代谢性疾病方面的应用。
• Compounds, pharmaceutical composition and methods for use in treating metabolic disorders
  申请人：Euroscreen S.A.

  公开号：EP2364297A1

  公开（公告）日：2011-09-14
• [EN] COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERS<br/>[FR] COMPOSÉS, COMPOSITION PHARMACEUTIQUE ET MÉTHODES POUR APPLICATION AU TRAITEMENT DE TROUBLES MÉTABOLIQUES
  申请人：EUROSCREEN SA

  公开号：WO2010066682A1

  公开（公告）日：2010-06-17

  The present invention is directed to novel compounds of formula (I) and their use in treating metabolic diseases.
• [EN] COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING GASTROINTESTINAL DISORDERS<br/>[FR] COMPOSÉS, COMPOSITION PHARMACEUTIQUE ET PROCÉDÉS POUR UTILISATION DANS LE TRAITEMENT DE TROUBLES GASTRO-INTESTINAUX
  申请人：EUROSCREEN SA

  公开号：WO2011076732A1

  公开（公告）日：2011-06-30

  The present invention relates to compounds of formula (I) useful in treating and/or preventing gastrointestinal disorders.