(S,E)-(3-((3-fluorobenzyl)oxy)prop-1-ene-1,3-diyl)dibenzene | 1342300-91-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (S,E)-(3-((3-fluorobenzyl)oxy)prop-1-ene-1,3-diyl)dibenzene
• 英文别名: 1-[[(E,1S)-1,3-diphenylprop-2-enoxy]methyl]-3-fluorobenzene
• CAS: 1342300-91-7
• 化学式: C₂₂H₁₉FO
• 分子量: 318.391
• InChiKey: NHPVCYNZKLOJKU-FRFYRWIFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-氟苄醇 、 (±)-反式-1,3-二苯基烯丙基乙酸酯 在 双(乙腈)氯化钯(II) 、 C₄₆H₄₅FeN₂P₂⁽¹⁺⁾*I^(1-) 、 caesium carbonate 作用下， 以 乙腈 为溶剂， 反应 4.0h， 生成 (S,E)-(3-((3-fluorobenzyl)oxy)prop-1-ene-1,3-diyl)dibenzene 、 (R,E)-(3-((3-fluorobenzyl)oxy)prop-1-ene-1,3-diyl)dibenzene
  参考文献：
  名称：

  Ionic-salt-tagged ferrocenyl diphosphine–imine ligands and their application to palladium-catalyzed asymmetric allylic etherification

  摘要：

  A new type of ferrocenyl diphosphine-imine ligands that contains an ionic salt group has been prepared, and successfully applied to asymmetric C*-O bond formation. In the Pd-catalyzed asymmetric allylic etherification of 1,3-diphenyl-2-propenyl acetate, high enantioselectivity was obtained (up to 91.0% ee). The potential of the catalysts to be recycled and reused has also been demonstrated. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2011.07.025

文献信息

• Ionic-salt-tagged ferrocenyl diphosphine–imine ligands and their application to palladium-catalyzed asymmetric allylic etherification
  作者：Li Dai、Xin Li、Hao Yuan、Xia Li、Zhihuai Li、Di Xu、Fan Fei、Yingqiang Liu、Jun Zhang、Zhiming Zhou

  DOI：10.1016/j.tetasy.2011.07.025

  日期：2011.7

  A new type of ferrocenyl diphosphine-imine ligands that contains an ionic salt group has been prepared, and successfully applied to asymmetric C*-O bond formation. In the Pd-catalyzed asymmetric allylic etherification of 1,3-diphenyl-2-propenyl acetate, high enantioselectivity was obtained (up to 91.0% ee). The potential of the catalysts to be recycled and reused has also been demonstrated. (C) 2011 Elsevier Ltd. All rights reserved.