1-[(1R)-3,3-dimethylcyclopentyl]ethanone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[(1R)-3,3-dimethylcyclopentyl]ethanone
• 化学式: C₉H₁₆O
• 分子量: 140.22
• InChiKey: IXWLGKFYZCHJRC-MRVPVSSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• SYNTHESIS OF ACYCLIC AND CYCLIC AMINES USING IRON-CATALYZED NITRENE GROUP TRANSFER
  申请人：PRESIDENT AND FELLOWS OF HARVARD COLLEGE

  公开号：US20160002145A1

  公开（公告）日：2016-01-07

  The present invention provides novel synthetic methods for making acyclic secondary amines by reacting an azide with a compound bearing one or more C—H groups, catalyzed by a Fe II -dipyrromethene complex. The acyclic secondary amines are thought to be formed through an intermolecular nitrene transfer. Also provided herein are methods of synthesizing protected (e.g., Boc- or Fmoc-protected) cyclic secondary amines (e.g., 5-, 6-, and 7-membered cyclic secondary amines) by reacting an azide that bears one or more C—H groups, catalyzed by a Fe II -dipyrromethene complex. The protected cyclic secondary amines are thought to be formed through an intramolecular nitrene transfer and may be subsequently deprotected to yield cyclic secondary amines.
• US9487472B2
  申请人：——

  公开号：US9487472B2

  公开（公告）日：2016-11-08
• US9724682B2
  申请人：——

  公开号：US9724682B2

  公开（公告）日：2017-08-08