(2R,3S,4R,5R)-2-(aminomethyl)-5-methoxyoxolane-3,4-diol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3S,4R,5R)-2-(aminomethyl)-5-methoxyoxolane-3,4-diol
• 化学式: C₆H₁₃NO₄
• 分子量: 163.17
• InChiKey: ODOKPZPCULYXKR-KVTDHHQDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  84.9
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• LARGE SCALE PREPARATION OF PSEUDO-TRISACCHARIDE AMINOGLYCOSIDES AND OF INTERMEDIATES THEREOF
  申请人：Eloxox Pharmaceuticals Ltd.

  公开号：US20220033428A1

  公开（公告）日：2022-02-03

  Synthetic pathways for preparing pseudo-trisaccharide aminoglycoside compounds represented by Formula I or Ia as defined in the specification and donor and acceptor compounds useful for preparing such compounds are provided. A process of stereoselectively preparing compounds represented by Formula III as defined in the specification, while avoiding chromatographic separation of stereoisomers are also provided. Compounds prepared by the described processes and uses thereof are also provided.