(5S)-5-[(2S)-butan-2-yl]oxolan-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: (5S)-5-[(2S)-butan-2-yl]oxolan-2-one
• 化学式: C₈H₁₄O₂
• 分子量: 142.2
• InChiKey: VBVXMQSVIFHPRP-BQBZGAKWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• NOVEL SUBSTITUTED AMINOTHIAZOLOPYRIMIDINEDIONE FOR THE TREATMENT AND PROPHYLAXIS OF VIRUS INFECTION
  申请人：Hoffmann-La Roche Inc.

  公开号：US20180093999A1

  公开（公告）日：2018-04-05

  The present invention relates to compounds of formula (I), wherein R 1 to R 5 are as described herein, and their prodrugs or pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
• Novel substituted aminothiazolopyrimidinedione for the treatment and prophylaxis of virus infection
  申请人：Hoffmann-La Roche Inc.

  公开号：US20180118763A1

  公开（公告）日：2018-05-03

  The present invention relates to compounds of formula (I), wherein R 1 to R 4 are as described herein, and their prodrugs or pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
• [EN] 3-SUBSTITUTED 5-AMINO-6H-THIAZOLO[4,5-D]PYRIMIDINE-2,7-DIONE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF VIRUS INFECTION<br/>[FR] COMPOSÉS 5-AMINO-6H-THIAZOLO [4,5-D]POUR LE TRAITEMENT ET LA PROPHYLAXIDE D'INFECTIONS VIRALES
  申请人：HOFFMANN LA ROCHE

  公开号：WO2016091698A1

  公开（公告）日：2016-06-16

  The present invention relates to compounds of formula (I), wherein R1, R2and R3are as described herein, and their prodrugs or pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds as TLR7 agonists for the treatment and prophylaxis of virus infections.