2-Methyl-4-ethoxy-butanol-(2) | 19769-18-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Methyl-4-ethoxy-butanol-(2)
• 英文别名: 4-ethoxy-2-methyl-butan-2-ol；4-Aethoxy-2-methyl-butan-2-ol；4-Ethoxy-2-methylbutan-2-ol
• CAS: 19769-18-7
• 化学式: C₇H₁₆O₂
• 分子量: 132.203
• InChiKey: ZOAIIZNXNGEVMW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-ethoxy-2-methylbut-3-yn-2-ol 在 palladium on activated charcoal 、 乙醇 作用下， 生成 2-Methyl-4-ethoxy-butanol-(2)
  参考文献：
  名称：

  Settlement pattern, environmental factors and ethnic background on a southwestern Quebec frontier (1795–1842)

  摘要：

  In studies of frontier settlement patterns, different site factors are recognized as influential on the immigrant settlement process. Environmental factors such as soil features, while widely cited as crucial, have rarely been studied in enough depth to measure their relationship to other phenomena such as ethnic attractiveness. Qualitative and quantitative case studies in early 19th century Godmanchester township's sequence of land occupancy indicate that pioneer settlers in this region of Quebec were influenced by a mixed set of factors that changed over time. In reconstructing Godmanchester's land colonization process and pattern based on local historical sources and Lower‐Canada manuscript censuses of 1825, 1831 and 1842, the traditional way of understanding such processes was put into question. Geomorphological deposits, while remaining a relatively decisive factor in determining settlement patterns until the end of the 1820s, were gradually displaced by ethnic proximity, as revealed in censuses up to 1842. To understand this settlement pattern, one must consider the pioneers' goals from their perspective: they were primarily interested in self‐sufficiency and were not all necessarily market‐oriented farmers. From this standpoint, attractive land to settle seems more appropriate than the standard assumption of good land for cash‐crop farming.Dans les études portant sur la colonisation des fronts pionniers, les variables reconnues susceptibles d'orienter la marche du peuplement sont multiples. Pour expliquer la localisation des colons, une majorité de ruralistes accorde la prépondérance aux propriétés du sol. Bien qu'elle soit considérée déterminante par plusieurs, l'attirance ethnique ne se voit pas attribuer une importance équivalente. Afin d'évaluer le rôle respectifde ces deux facteurs, nous avons reconstitué l'occupation initiale du sol dans le canton de Godmanchester (Québec). Pour y parvenir, nous avons consulté l'historiographie locale et dépouillé les recensements nominatifs de 1825, 1831 et 1842. Nos résultats indiquent que les deux variables examinées exercent une influence sur l'orientation du peuplement mais que leur attrait respectif ne s'exprime pas nécessairement au même moment. Après avoir été décisifs jusqu'à la fin des années 1820, les dépôts de surface semblent ensuite perdent de leur influence au profit de l'attirance ethnique. Pour comprendre ce patron d'implantation, il importe de reconnaître que les colons sont des producteurs résidentiels plutôt que des agriculteurs commerciaux. Ces derniers recherchent probablement davantage des sites facilitant l'établissement de leur famille que des terres propices à l'agriculture de marché.

  DOI：

  10.1111/j.1541-0064.2002.tb00736.x

文献信息

• BIOMIMETIC COMPOUNDS AND SYNTHETIC METHODS THEREFOR
  申请人：Lee Bruce P.

  公开号：US20100197868A1

  公开（公告）日：2010-08-05

  Synthesis methods for creating polymeric compounds comprising dihydroxyphenyl derivatives (DHPD), or DHPp i.e. polymers modified with DHPD, with desired surface active effects are described. The polymer backbone of DHPp has structural or performance features that can be tailored to control physical properties of DHPp, allowing it to be useful for different applications i.e. tissue adhesives or sealants, adhesion promoting coatings, and antifouling coatings.

  本文介绍了用于制造含二羟基苯基衍生物（DHPD）或DHPp的聚合物化合物的合成方法，即通过DHPD改性的聚合物，具有所需的表面活性效果。 DHPp的聚合物骨架具有可定制的结构或性能特征，可以控制DHPp的物理特性，使其在不同的应用中有用，例如组织粘合剂或密封剂，促进粘附涂层和防污涂层。
• Prodrugs containing novel bio-cleavable linkers
  申请人：Piramal Life Sciences Limited

  公开号：EP2266622A2

  公开（公告）日：2010-12-29

  The invention provides the compounds of formula (I) or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutical compositions comprising one or more compounds of formula I or intermediates thereof and one more of pharmaceutically acceptable carriers, vehicles or diluents. The invention further provides methods of preparation and methods of use of prodrugs including NO-releasing prodrugs, double prodrugs and mutual prodrugs comprising the compounds of formula 1.

  本发明提供了式 (I) 化合物或其药学上可接受的盐。本发明还提供了包含一种或多种式 I 化合物或其中间体以及一种或多种药学上可接受的载体、载体或稀释剂的药物组合物。本发明进一步提供了包括NO释放原药、双原药和包含式1化合物的互作原药在内的原药的制备方法和使用方法。
• Prodrugs Containing Novel Bio-Cleavable Linkers
  申请人：Piramal Life Sciences Limited

  公开号：EP2266625A2

  公开（公告）日：2010-12-29

  The invention provides the compounds of formula (I) or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutical compositions comprising one or more compounds of formula I or intermediates thereof and one more of pharmaceutically acceptable carriers, vehicles or diluents. The invention further provides methods of preparation and methods of use of prodrugs including NO-releasing prodrugs, double prodrugs and mutual prodrugs comprising the compounds of formula 1.

  本发明提供了式 (I) 化合物或其药学上可接受的盐。本发明还提供了包含一种或多种式 I 化合物或其中间体以及一种或多种药学上可接受的载体、载体或稀释剂的药物组合物。本发明进一步提供了包括NO释放原药、双原药和包含式1化合物的互作原药在内的原药的制备方法和使用方法。
• CYCLIC PEPTIDE COMPOUND HAVING HIGH MEMBRANE PERMEABILITY, AND LIBRARY CONTAINING SAME
  申请人：Chugai Seiyaku Kabushiki Kaisha

  公开号：EP3636807A1

  公开（公告）日：2020-04-15

  The present inventors have found that when screening for cyclic peptide compounds that can specifically bind to a target molecule, the use of a library including cyclic peptide compounds having a long side chain in the cyclic portion can improve the hit rate for cyclic peptide compounds that can specifically bind to the target molecule. Meanwhile, the present inventors have found that tryptophan and tyrosine residues, which have conventionally been used in oral low molecular-weight pharmaceuticals and are amino acid residues having an indole skeleton or a hydroxyphenyl group, are not suitable for peptides intended to attain high membrane permeability.

  本发明人发现，在筛选能与目标分子特异性结合的环肽化合物时，使用包括环状部分具有长侧链的环肽化合物库，可以提高能与目标分子特异性结合的环肽化合物的命中率。同时，本发明者发现色氨酸和酪氨酸残基不适合用于旨在获得高膜渗透性的肽，这两种残基通常用于口服低分子量药物，是具有吲哚骨架或羟基苯基的氨基酸残基。
• Synthesis of 3-hydroxy aldehydes, 3-hydroxy acetals, and 3-hydroxy ethers from 2-alkoxy oxetanes
  作者：Siegfried H. Schroeter

  DOI：10.1021/jo01257a002

  日期：1969.5